Sarcomas: From Molecular Signatures to Morphologic Patterns
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 10
Special Issue Editor
2. Pathology Department, Hospital Quironsalud, Valencia, Spain
Interests: bone and soft tissue tumor; solitary fibrous tumor; ewing sarcoma; round cell sarcomas; gastrointestinal pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although certain genetic alterations are associated with specific types of sarcoma, many genetic alteration genes, including fusion genes, can be found in entirely different benign or malignant entities. Therefore, molecular alterations should not be evaluated in isolation but should be integrated with all clinical and morphological findings. This is especially important when entities are defined solely by the presence of a specific molecular alteration. An approach based on molecular alterations alone may be misleading unless large cohorts with that particular alteration have already been analyzed to better predict the behavior of the associated sarcoma.
The aim of this Special Issue is to highlight emerging insights into the relationship between genetic alterations and specific morphologic phenotypes in sarcomas. Interestingly, some genetic abnormalities consistently produce distinct morphologic patterns that can serve as structural signatures, indicating the presence of particular molecular changes. The key is to make optimal use of both traditional morphologic evaluation and modern molecular tools to understand how genetic alterations influence morphology, as well as how histopathological features can, in turn, help to predict underlying genetic defects. Such integration would enhance diagnostic accuracy and support more effective disease management and follow up.
Dr. Isidro Machado
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sarcomas
- histopathology
- molecular pathology
- FISH
- gene fusion in sarcomas
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
