Sarcomas: From Molecular Signatures to Morphologic Patterns
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 33
Special Issue Editor
2. Pathology Department, Hospital Quironsalud, Valencia, Spain
Interests: bone and soft tissue tumor; solitary fibrous tumor; ewing sarcoma; round cell sarcomas; gastrointestinal pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although certain genetic alterations are associated with specific types of sarcoma, many genetic alteration genes, including fusion genes, can be found in entirely different benign or malignant entities. Therefore, molecular alterations should not be evaluated in isolation but should be integrated with all clinical and morphological findings. This is especially important when entities are defined solely by the presence of a specific molecular alteration. An approach based on molecular alterations alone may be misleading unless large cohorts with that particular alteration have already been analyzed to better predict the behavior of the associated sarcoma.
The aim of this Special Issue is to highlight emerging insights into the relationship between genetic alterations and specific morphologic phenotypes in sarcomas. Interestingly, some genetic abnormalities consistently produce distinct morphologic patterns that can serve as structural signatures, indicating the presence of particular molecular changes. The key is to make optimal use of both traditional morphologic evaluation and modern molecular tools to understand how genetic alterations influence morphology, as well as how histopathological features can, in turn, help to predict underlying genetic defects. Such integration would enhance diagnostic accuracy and support more effective disease management and follow up.
Dr. Isidro Machado
Guest Editor
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Keywords
- sarcomas
- histopathology
- molecular pathology
- FISH
- gene fusion in sarcomas
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