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  • Review
  • Open Access

β-Hairpin-Based Peptide Hydrogels: The Case of MAX1

  • Mariantonietta Pizzella,
  • Valéria Gomes,
  • Enrico Gallo,
  • Sérgio Veloso,
  • Célio Fernandes,
  • Antonella Accardo and
  • Carlo Diaferia
Gels2026, 12(2), 100;https://doi.org/10.3390/gels12020100 
(registering DOI)

24 January 2026

This review explores the advancements and applications of β-hairpin peptide hydrogels, starting from the paradigmatic case of MAX1 and its highly versatile analogue MAX8. MAX1 (H-VKVKVKVKVDPPTKVKVKVKV-NH2) has been identified as the first synthe...

  • Article
  • Open Access
Gels2026, 12(2), 99;https://doi.org/10.3390/gels12020099 
(registering DOI)

24 January 2026

Conductive hydrogels that simultaneously exhibit high mechanical robustness, reliable electrical conductivity, and interfacial adhesion are highly desirable for flexible sensing applications; however, achieving these properties in a single system rem...

  • Review
  • Open Access

Recent Advances in Smart Stimulus-Responsive Hydrogels for Precision Drug Delivery in Tumours

  • Huiling Zuo,
  • Yuhang Jiao,
  • Jiaxin Chen,
  • Sen Tong,
  • Yan Li and
  • Wei Zhao
Gels2026, 12(2), 98;https://doi.org/10.3390/gels12020098 
(registering DOI)

23 January 2026

Cancer remains one of the most prominent global health concerns, posing a substantial threat to public health. Millions of people die from cancer each year, and many cancer types remain incurable at present. Conventional cancer treatments, including...

  • Article
  • Open Access
Gels2026, 12(1), 97;https://doi.org/10.3390/gels12010097 
(registering DOI)

22 January 2026

Cleaning historical silk textiles is a particularly sensitive operation that requires precise control to prevent mechanical or chemical damage. In this study, we investigate using flexible PVA–borax-based gels to remove soot from silk, i.e., po...

  • Article
  • Open Access

Annealing-Fabricated Poria cocos Glucan-Tannic Acid Composite Hydrogels: Integrated Multifunctionality for Accelerated Wound Healing

  • Yong Gao,
  • Ruyan Qian,
  • Chenyi Feng,
  • Dan Li,
  • Xinmiao He,
  • Wengui Xu,
  • Jiaxin Zhu and
  • Zongbao Zhou
Gels2026, 12(1), 96;https://doi.org/10.3390/gels12010096 
(registering DOI)

22 January 2026

Multifunctional wound dressings integrating moisture retention, antibacterial activity, and bioactive delivery are in demand, yet balancing structural stability and functional synergy in polysaccharide hydrogels remains a challenge. This study focuse...

  • Article
  • Open Access
Gels2026, 12(1), 95;https://doi.org/10.3390/gels12010095 
(registering DOI)

22 January 2026

Needle-free injection (NFI) technology is a promising alternative to conventional syringe injection, as it mitigates needle-related complications and enhances patient compliance. However, achieving the controlled and efficient dispersion of larger-vo...

  • Article
  • Open Access
Gels2026, 12(1), 94;https://doi.org/10.3390/gels12010094 
(registering DOI)

22 January 2026

Starches play a crucial role in determining the expansion, texture, and structural development of extruded meat analogs through their gelatinization behavior and interactions with proteins. In this study, corn, pea, tapioca, sweet potato, and potato...

  • Article
  • Open Access
142 Views
17 Pages

21 January 2026

A biomimetic cartilage scaffold featuring a continuous hydroxyapatite (HA) concentration gradient and a spatially curved architecture was developed using a dual-channel mixing extrusion-based 3D printing approach. By dynamically regulating the feedin...

  • Article
  • Open Access
75 Views
17 Pages

Hydroxyapatite-Mediated Mechanical Modulation of GelMA Hydrogels Influences Osteogenic Differentiation of 3D Spheroids

  • Narantungalag Amarbayasgalan,
  • Ji Hyeon Kim,
  • Won-Gun Koh,
  • Karthika Muthuramalingam and
  • Hyun Jong Lee

20 January 2026

Substrate stiffness critically regulates osteogenic differentiation, yet systematic identification of optimal mechanical conditions in three-dimensional culture remains limited. This study investigated how hydroxyapatite (HAp)-mediated mechanical mod...

  • Article
  • Open Access
104 Views
12 Pages

A 3D Collagen–Alginate Hydrogel Model for Mechanoregulation of Autophagy in Periodontal Ligament Cells

  • Xueping Kang,
  • Bei Gao,
  • Tong Wang,
  • Qingbo Zhao,
  • Shiyang Wu,
  • Chuqi Li,
  • Hui Zhang,
  • Rui Zou and
  • Yijie Wang

20 January 2026

Mechanical loading is a central cue in periodontal tissues, where compression of the periodontal ligament guides remodeling and orthodontic tooth movement (OTM). However, most mechanobiology studies have used two-dimensional cultures with poorly defi...

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Gels - ISSN 2310-2861