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Poly(N-isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications

Industrial and Digital Innovation Department (DIID), Chemical Engineering, University of Palermo, Viale delle Scienze, Ed. 8, 90128 Palermo, Italy
Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/d’Eduard Maristany, 10-14, Building I, E-08019 Barcelona, Spain
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Campus Diagonal Besòs (EEBE), C/d’Eduard Maristany 10-14, Edifici IS, 08019 Barcelona, Spain
Author to whom correspondence should be addressed.
Received: 15 August 2017 / Revised: 29 September 2017 / Accepted: 3 October 2017 / Published: 4 October 2017
(This article belongs to the Special Issue Organogels for Biomedical Applications)
PDF [16628 KB, uploaded 11 October 2017]


The innate ability of poly(N-isopropylacrylamide) (PNIPAAm) thermo-responsive hydrogel to copolymerize and to graft synthetic polymers and biomolecules, in conjunction with the highly controlled methods of radical polymerization which are now available, have expedited the widespread number of papers published in the last decade—especially in the biomedical field. Therefore, PNIPAAm-based hydrogels are extensively investigated for applications on the controlled delivery of active molecules, in self-healing materials, tissue engineering, regenerative medicine, or in the smart encapsulation of cells. The most promising polymers for biodegradability enhancement of PNIPAAm hydrogels are probably poly(ethylene glycol) (PEG) and/or poly(ε-caprolactone) (PCL), whereas the biocompatibility is mostly achieved with biopolymers. Ultimately, advances in three-dimensional bioprinting technology would contribute to the design of new devices and medical tools with thermal stimuli response needs, fabricated with PNIPAAm hydrogels. View Full-Text
Keywords: poly(N-isopropylacrylamide); thermo-responsive polymer; copolymers; biocompatibility; biodegradability; 4D-printing poly(N-isopropylacrylamide); thermo-responsive polymer; copolymers; biocompatibility; biodegradability; 4D-printing

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lanzalaco, S.; Armelin, E. Poly(N-isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications. Gels 2017, 3, 36.

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