Molecular Research in Osteoporosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 53
Special Issue Editors
Interests: genetics; epigenetics; molecular biology; osteoporosis; osteosarcopenia; myotonic dystrophies
Interests: myotonic dystrophies; epigenetics; medical genetics; neuromuscular diseases; biomarkers; molecular diagnosis
Special Issues, Collections and Topics in MDPI journals
Interests: osteoporosis; bone metabolism; fracture healing; osteoarthritis; age related-bone disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Osteoporosis is the most prevalent bone disease, characterized by the micro-architectural deterioration of bone tissue, often associated with decreased muscle mass. Bone and muscle are intimately connected biomechanically and biochemically, together constituting the bone–muscle unit. The presence of low bone and muscle quality, reflecting the concomitant diagnosis of osteoporosis and sarcopenia, is currently referred to as “osteosarcopenia”. The pathogenesis of osteoporosis reflects complex interactions among genetic, hormonal, and environmental factors, which have not yet been fully characterized. These shortcomings, together with the related risk of developing fragility fractures, represent a major social burden which significantly impacts the quality of human life. In this context, it is crucial that we globally characterize the genetic determinants of osteoporosis through genome-wide association studies aimed at identifying genetic loci associated with low bone mineral density and osteoporotic fractures. Moreover, in-depth explorations of epigenetic mechanisms, such as DNA methylation, non-coding RNAs, and histone modification, may better define the signatures of the impaired bone metabolism. This Special Issue will summarize the current knowledge on the molecular mechanisms underlying osteoporosis. To this end, we are pleased to invite submissions of research articles and reviews addressing the characterization of novel genetic and transcriptomic biomarkers of osteoporosis to implement clinical tools against bone–muscle unit decay.
Dr. Virginia Visconti
Dr. Annalisa Botta
Prof. Dr. Umberto Tarantino
Guest Editors
Manuscript Submission Information
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Keywords
- osteoporosis
- osteosarcopenia
- bone–muscle crosstalk
- genetics, epigenetics
- transcriptomics
- biomarkers
- therapeutic strategy
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