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Cells
Special Issues
Integrated Approaches Between Metabolomics and Cellular Aging
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Integrated Approaches Between Metabolomics and Cellular Aging

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 2496

Special Issue Editors

Dr. Maria Nikolaou

E-Mail Website
Guest Editor
Department of Cardiology, Preventive Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Street, 15127 Melissia, Greece
Interests: cardiometabolic medicine; cardiovascular endocrinology and metabolism; preventive cardiology and rehabilitation; heart failure; cardiogeriatrics; clinical epidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Nikolaos Theodorakis

E-Mail Website
Guest Editor Assistant
1. Department of Cardiology, Preventive Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Street, 15127 Melissia, Greece
2. School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 11527 Athens, Greece
3. NT-CardioMetabolics, Clinic for Metabolism and Athletic Performance, 47 Tirteou Street, 17564 Palaio Faliro, Greece
Interests: cardiometabolic medicine; cardiovascular endocrinology and metabolism; preventive cardiology and rehabilitation; heart failure; cardiogeriatrics; clinical epidemiology

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the intersection of metabolomics and cellular aging, exploring how changes in metabolism influence aging at the cellular level and contribute to the development of age-related diseases. The issue aims to integrate the latest insights from metabolomic profiling with the biology of aging, highlighting how metabolic pathways, biomarkers, and cellular responses to oxidative stress, inflammation, and damage accumulation impact aging and cellular function.

Topics covered will include the following:

  • Metabolomics in Cellular Aging: Investigating how metabolic changes occur with aging at the cellular level and how specific metabolites influence aging-related cellular processes such as senescence, mitochondrial dysfunction, and DNA damage.
  • Biomarkers of Cellular Aging: Identifying and validating metabolites and metabolic pathways as biomarkers of cellular aging, and their potential use in assessing age-related diseases and healthspan.
  • Cellular Mechanisms of Aging: Exploring how metabolism regulates key cellular processes involved in aging, including autophagy, apoptosis, and cell cycle control, and the role of metabolites in modulating these processes.
  • Therapeutic Interventions Targeting Metabolic Pathways in Aging: Examining the potential of metabolic modulation, such as through dietary interventions, drugs, or nutraceuticals, to slow cellular aging and prevent age-related diseases, with an emphasis on the role of metabolomics in developing these interventions.
  • Multi-Omics Approaches to Aging: Using integrative systems biology and multi-omics approaches to better understand the complex relationship between metabolism, aging, and cellular health, and identifying novel therapeutic strategies. Submissions are expected to include original research articles and review papers that advance our understanding of the role of metabolism in cellular aging.

Contributions that incorporate cutting-edge metabolomic technologies, explore novel aging biomarkers, and highlight therapeutic strategies for promoting healthy aging are especially welcome.

Dr. Maria Nikolaou
Guest Editor

Dr. Nikolaos Theodorakis
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • cellular aging
  • senescence
  • mitochondrial dysfunction
  • DNA damage
  • biomarkers
  • metabolism

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

29 pages, 1005 KB  
Review
Metabolomic Investigation of Myelodysplastic Syndromes, Multiple Myeloma, and Homozygous β-Thalassemia
by Elena Chatzikalil, Konstantinos Bistas, Vasiliki Kymioni, Panagiotis T. Diamantopoulos and Elena E. Solomou
Cells 2025, 14(22), 1788; https://doi.org/10.3390/cells14221788 - 14 Nov 2025
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Abstract
Chronic anemia is commonly diagnosed in older adults and serves an important indicator of both reactive and clonal conditions. Many underlying diseases, such as myelodysplastic syndromes and multiple myeloma, are more prevalent amongst the elderly, while novel therapeutic approaches have transformed pediatric disorders [...] Read more.
Chronic anemia is commonly diagnosed in older adults and serves an important indicator of both reactive and clonal conditions. Many underlying diseases, such as myelodysplastic syndromes and multiple myeloma, are more prevalent amongst the elderly, while novel therapeutic approaches have transformed pediatric disorders of poor prognosis, such as beta-thalassemia, to a chronic disease of older adults. Thus, the increasing prevalence of chronic anemia in older ages is largely attributed to more frequent diagnostic and therapeutic evaluations and demographic changes. The etiology of anemia in adults is complex, ranging from genetic mutations to bone marrow failure syndromes, chronic kidney disease, nutritional deficiencies, and inflammatory processes, while in some cases no clear etiology is found. For this reason, extensive research is ongoing to introduce novel therapeutic targets and improve quality of life. Management of anemia in adults depends on severity and especially on the underlying conditions of each patient. Metabolic pathway analyses have revealed alterations in various pathways, including glycolysis, pyruvate, propanoate, glycerophospholipid, galactose, fatty acid, starch, and sucrose metabolism along with fatty acid elongation in mitochondria, glycerolipid, glyoxylate, and dicarboxylate metabolism in adult patients with chronic anemia compared to healthy individuals, which may serve as potential new therapeutic targets. In this review, we aim to (i) summarize current evidence regarding metabolic disturbances in diseases of age-related hematopoietic dysregulation, being represented by multiple myeloma and myelodysplastic syndromes, and in β-thalassemia, a disease model of accelerating cellular aging; and (ii) describe novel therapeutic metabolic-targeted options for the aforementioned diseases, focusing on the need for continuous research in this field. Full article
(This article belongs to the Special Issue Integrated Approaches Between Metabolomics and Cellular Aging)
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16 pages, 467 KB  
Review
Obesity-Related Inflammatory Biomarkers in the Elderly Population
by Georgia Vamvakou, Nikolaos Theodorakis, Dimitris Anagnostou, Magdalini Kreouzi, Loukianos S. Rallidis, Vasiliki Katsi, Effie Simou, Stefanos Archontakis, George Skalis, Christos Hitas, Konstantinos Toutouzas and Maria Nikolaou
Cells 2025, 14(21), 1733; https://doi.org/10.3390/cells14211733 - 4 Nov 2025
Viewed by 1061
Abstract
Obesity in elderly individuals is associated with increased levels of inflammatory biomarkers, indicating a state of chronic low-grade inflammation, which has been recently termed as adipaging. Several studies have demonstrated this relationship: overweight and obese middle-aged and elderly individuals show elevated levels of [...] Read more.
Obesity in elderly individuals is associated with increased levels of inflammatory biomarkers, indicating a state of chronic low-grade inflammation, which has been recently termed as adipaging. Several studies have demonstrated this relationship: overweight and obese middle-aged and elderly individuals show elevated levels of inflammatory markers like CXCL-16, IL-6, and adipokines compared to normal weight counterparts. These markers positively correlate with anthropometric parameters indicating increased cardiovascular risk. C-reactive protein (CRP) and fibrinogen levels increase progressively with higher obesity classes in the general population, including the elderly. For instance, CRP levels nearly double with each increase in weight class compared to normal weight individuals. Additionally, the presence of obesity-related comorbidities like hypertension or diabetes further elevates these inflammatory markers. In conclusion, obesity in the elderly is characterized by elevated levels of various inflammatory biomarkers, reflecting a state of chronic low-grade inflammation. This inflammatory state may contribute to the development of obesity-related comorbidities. The clarification of the complementary or independent role of these biomarkers in aging and obesity could lead to targeted therapeutic interventions in this vulnerable population group. Full article
(This article belongs to the Special Issue Integrated Approaches Between Metabolomics and Cellular Aging)
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