Mitochondria in Cancer Immune Evasion and Immunotherapy

Dear Colleagues,

Mitochondria are essential metabolic, biosynthetic and signaling hubs regulating cell proliferation, differentiation and apoptosis. In addition to being the powerhouse of the cell, mitochondria represent the powerhouse of immunity as they support development, differentiation and metabolic plasticity of immune cells. The mitochondrial dynamics (fusion/fission), genome (mtDNA) and metabolism are altered in the cells within the tumor microenvironment and these changes contribute to fostering immune tolerance and cancer immune evasion. The intercellular transfer of mitochondria within the tumor microenvironment adds a further layer of complexity to the mechanisms driving cancer immune evasion.

The aim of this Special Issue is to explore mitochondria-related mechanisms of cancer immune evasion and immune tolerance, and applications in cancer immunotherapy.

Dr. Loredana Moro
Guest Editor

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