Epigenetic and Metabolic Regulation of Cancer—2nd Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: 20 July 2026
Special Issue Editors
Interests: cancer; cancer stem cell; drug resistance; epigenetics; epitranscriptomics
Interests: cancer metabolism; cell-stress-responsive signaling; cancer stem cells; molecular and cellular biology of cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer cells exhibit widespread alterations in gene expression and cellular metabolism, driving their hallmark malignant traits such as uncontrolled proliferation, impaired differentiation, stemness, metastasis, therapeutic resistance, and immune evasion. These transcriptional abnormalities often arise from disruptions in the epigenetic machinery—including aberrant DNA methylation, histone modifications, chromatin remodeling, histone variant dynamics, enhancer dysfunction, and altered 3D genome architecture—driven by the aberrant regulation of epigenetic regulators or signaling pathways that reshape chromatin states.
In parallel, cancer cells undergo extensive metabolic reprogramming in response to microenvironmental stress, mutations in metabolic genes, and epigenetic control of metabolic pathways. Metabolic alterations in immune and stromal cells further contribute to tumor progression. Because many chromatin-modifying enzymes require specific metabolites as essential cofactors, epigenetic and metabolic programs are tightly interconnected and collectively reinforce tumorigenic cell states and therapeutic resistance.
This mechanistic interplay presents promising therapeutic opportunities. Epigenetic agents, metabolic inhibitors, and combination strategies are designed to exploit these vulnerabilities and, in some contexts, enhance antitumor immunity.
This Special Issue will showcase original research and reviews that explore the epigenetic and metabolic regulation of cancer. Contributions will advance this field and support the development of new therapeutic regimens.
Dr. Jung-Hyun Kim
Dr. Ming Tan
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- epigenetic
- transcription
- chromatin
- tumor metabolism
- immunometabolism
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Related Special Issue
- Epigenetic and Metabolic Regulation of Cancer in Cells (8 articles)
