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Cells
Special Issues
Cellular and Molecular Mechanisms of Vascular-Related Diseases
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Cellular and Molecular Mechanisms of Vascular-Related Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 767

Special Issue Editors

Prof. Dr. Bingmei Fu

E-Mail Website
Guest Editor
Department of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA
Interests: the blood–brain barrier; glycocalyx; vascular permeability; vascular signaling; tumor metastasis via microcirculation
Special Issues, Collections and Topics in MDPI journals
Dr. Ye Zeng

E-Mail Website
Guest Editor
Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China
Interests: cardiovascular and cerebrovascular diseases; angiogenesis; glycocalyx; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vascular-related diseases occur in large, small and micro vessels. They include atherosclerosis, aneurysm, coronary microcirculation dysfunction, stroke and cerebral hemorrhage, and infectious diseases, to name a few. In addition, chronic diabetes and chronic kidney disease induce vascular complications and tumor cells utilize the vascular system for their metastasis. Alzheimer’s disease, epilepsy, meningitis, traumatic brain injury, multiple sclerosis, amyotrophic lateral sclerosis (ALS) and other CNS disorders all have dysfunctional vascular systems. To develop effective and efficient therapeutic strategies, it is necessary to elucidate the cellular and molecular mechanisms of these vascular-related diseases.

This Special Issue will collect research articles and review articles that investigate the above-mentioned mechanisms using animal models and cell culture models, in addition to other studies.

Prof. Dr. Bingmei Fu
Dr. Ye Zeng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular and molecular mechanisms
  • cardiovascular disease
  • cerebrovascular disease
  • vascular signaling
  • vascular dysfunctions in cns disorders
  • vascular dysfunctions in diabetes
  • vascular dysfunction in chronic kidney disease
  • tumor metastasis via vascular system

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

19 pages, 4640 KiB  
Article
A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood–Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow
by Yunfei Li and Bingmei M. Fu
Cells 2025, 14(6), 456; https://doi.org/10.3390/cells14060456 - 19 Mar 2025
Viewed by 512
Abstract
By utilizing polydimethylsiloxane (PDMS), collagen hydrogel, and a cell line for human cerebral microvascular endothelial cells, we produced a 3D microchannel blood–brain barrier (BBB) model under physiological flow. This 3D BBB has a circular-shaped cross-section and a diameter of ~100 μm, which can [...] Read more.
By utilizing polydimethylsiloxane (PDMS), collagen hydrogel, and a cell line for human cerebral microvascular endothelial cells, we produced a 3D microchannel blood–brain barrier (BBB) model under physiological flow. This 3D BBB has a circular-shaped cross-section and a diameter of ~100 μm, which can properly mimic the cerebral microvessel responsible for material exchange between the circulating blood and brain tissue. The permeability of the 3D microchannel BBB to a small molecule (sodium fluorescein with a molecular weight of 376) and that to a large molecule (Dex-70k) are the same as those of rat cerebral microvessels. This 3D BBB model can replicate the effects of a plasma protein, orosomucoid, a cytokine, vascular endothelial growth factor (VEGF), and an enzyme, heparinase III, on either rat cerebral or mesenteric microvessesels in terms of permeability and the modulation of glycocalyx (heparan sulfate). It can also replicate the adhesion of a breast cancer cell, MDA-MB-231, in rat mesenteric microvessels under no treatment or treatments with VEGF, orosomucoid, and heparinase III. Because of difficulties in accessing human cerebral microvessels, this inexpensive and easy to assemble 3D human BBB model can be applied to investigate BBB-modulating mechanisms in health and in disease and to develop therapeutic interventions targeting tumor metastasis to the brain. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Vascular-Related Diseases)
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