Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 48
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bone is a dynamic tissue that is continuously remodelled through the coordinated actions of osteoblasts, osteoclasts, and osteocytes. Disruption of these finely balanced processes underlies a wide spectrum of bone diseases, including osteoporosis, osteoarthritis, Paget’s disease and inflammatory bone loss. Recent research has begun to explore the complex molecular and cellular networks that govern bone homeostasis and has identified key roles for signalling pathways such as RANK/RANKL/OPG, Wnt/β-catenin, mechanical factors and bone–tissue crosstalk. This Special Issue invites contributions exploring the fundamental biology of osteoblasts, osteoclasts and osteocytes, mechanisms driving bone remodelling, and translational research aimed at targeting skeletal pathologies. We welcome original research, reviews, and methodological advances focusing on cell signalling, transcriptional regulation, epigenetics, biomaterials, therapeutic interventions and bone crosstalk. By fostering a deeper understanding of the cellular mechanisms involved in bone health and disease, this Special Issue aims to support the development of innovative treatments and diagnostic tools for skeletal disorders.
Dr. Thomas Nicholson
Guest Editor
Manuscript Submission Information
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Keywords
- osteoblasts
- osteoclasts
- bone remodelling
- osteoporosis
- skeletal diseases
- bone homeostasis
- bone interactions
- bone crosstalk
- targeted therapies
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