Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

Dear Colleagues,

Toxicology is entering a new era driven by the rapid development of advanced cellular models, high-throughput technologies, and systems biology approaches. Understanding how toxicants interact with cellular pathways is essential for elucidating mechanisms of toxicity, identifying biomarkers, and developing safer chemicals and drugs.

This Special Issue, “Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models”, aims to highlight recent advances in the study of toxic effects at the cellular and molecular level. We welcome original research articles, comprehensive reviews, and methodological papers focusing on how cells respond to environmental, pharmaceutical, and industrial toxicants.

Topics of interest include (but are not limited to) the following:

• Mechanisms of cellular stress, apoptosis, autophagy, and necroptosis induced by toxicants;
• Mitochondrial dysfunction, oxidative stress, and ER stress in toxicity;
• Cellular uptake and processing of nanoparticles and other emerging contaminants;
• Organoid, organ-on-a-chip, and 3D cell models for toxicity testing;
• Toxicogenomics, proteomics, metabolomics, and single-cell omics approaches;
• Epigenetic alterations and molecular biomarkers of toxicity;
• Drug-induced liver, kidney, and cardiac toxicity in cell systems;
• Immunotoxicity and inflammatory responses at the cellular level;
• Integration of in vitro and in silico methods for predictive toxicology;
• AI, machine learning, and systems biology approaches in mechanistic toxicology.

This Special Issue will provide a platform for presenting innovative approaches that bridge the gap between cellular biology and toxicology, contributing to the development of mechanism-based safety assessment and precision toxicology.

Dr. Maria Jurczuk
Dr. Patrice X. Petit
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.