The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 28 February 2026 | Viewed by 36
Special Issue Editors
Interests: spatial transcriptomics; single-cell RNA-seq; beta-cell regeneration; type 1 diabetes; pancreatic biology; ductal-to-beta cell differentiation
Interests: pancreatic regeneration; stem cell therapy; beta-cell differentiation; type 2 diabetes; islet biology
Special Issue Information
Dear Colleagues,
The rising prevalence of Type 2 Diabetes (T2D) and obesity worldwide underscores the urgent need for deeper understanding of pancreatic beta-cell biology. This Special Issue aims to explore the molecular, cellular, and metabolic mechanisms by which beta-cells adapt—or fail to adapt—to increased insulin demand in the context of obesity and T2D. We welcome submissions focusing on beta-cell proliferation, dedifferentiation, apoptosis, stress responses, and the role of incretin-based therapies such as GLP-1 receptor agonists in beta-cell preservation and regeneration. Studies leveraging cutting-edge technologies, including single-cell omics, lineage tracing, and spatial transcriptomics, are particularly encouraged. This Special Issue provides a platform for researchers to share discoveries that could shape future therapeutic strategies in diabetes care.
Dr. Mayur Doke
Prof. Dr. Juan Domínguez-Bendala
Dr. Oscar Alcazar
Guest Editors
Manuscript Submission Information
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Keywords
- pancreatic beta-cells
- GLP-1
- obesity
- type 2 diabetes
- islet biology
- beta-cell regeneration
- insulin resistance
- incretin therapies
- single-cell transcriptomics
- metabolic stress
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