Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 1838
Special Issue Editors
Interests: adipose-derived stem cells; neural differentiation; conditioned media; Schwann cells; olfactory ensheathing cells
Special Issues, Collections and Topics in MDPI journals
Interests: cell signaling; metabolic remodeling; differentiation pathways, oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Stem cells (SCs) can be isolated from various sources and are capable of differentiating into different cell types. They have garnered significant interest due to their key role in regenerative medicine. Numerous diseases and tissue injuries affect humans, such as sarcopenia, fractures, neurodegeneration, spinal cord injury, diabetes, and osteochondral defects. These conditions induce the loss or dysfunction of tissue cells and can compromise stem cells residing in tissue niches, reducing their regenerative capacity. Therefore, it is necessary to gain a deeper understanding of the mechanisms behind differentiation processes to develop appropriate therapeutic strategies, aiming to enhance the differentiation potential of resident stem cells or improve the efficacy of treatments based on differentiated cells, including adult, induced pluripotent, and embryonic stem cells.
This Special Issue, “Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation”, focuses on the cell biology, physiology, molecular biology, biophysics, and biochemical mechanisms underlying the various stages of differentiation. We particularly seek studies that compare different stem cell sources or differentiation strategies that may explain diverse physiological responses and those that develop an organoid as a potential in vitro model.
This Special Issue welcomes bioinformatic analyses, review articles and original data pertaining to its scope.
Dr. Giuliana Mannino
Dr. Floriana D'Angeli
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stem cells
- differentiation
- 3D cultures
- co-cultures
- biochemistry
- physiology
- epigenetics
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