Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 30 July 2026 | Viewed by 2
Special Issue Editors
Interests: breast cancer; immunotherapy; cancer vaccines; genomics; epigenetics; stem cells; endocrine resistance
Interests: breast cancer; immunotherapy; cancer vaccines
Special Issue Information
Dear Colleagues,
Breast cancer is a clinically heterogeneous disease in which therapeutic outcomes are increasingly driven by molecular subtype, tumor biology, and host immune contexture. The introduction of targeted therapies, including endocrine agents, HER2-directed treatments, CDK4/6 inhibitors, PARP inhibitors, and antibody–drug conjugates, has transformed the management of multiple breast cancer subtypes. In parallel, immunotherapeutic approaches, such as immune checkpoint inhibitors and cancer vaccines, have demonstrated clinical benefit, particularly in triple-negative breast cancer. Despite these advances, many patients experience primary resistance, limited durability of response, or treatment-related toxicities, highlighting the urgent need for improved patient selection and rational combination strategies.
This Special Issue will focus on clinically relevant insights into the application of targeted therapies and immunotherapy in breast cancer. Emphasis will be placed on translational studies, biomarker-driven treatment approaches, mechanisms of therapeutic resistance, and immune correlates of response. Contributions addressing treatment optimization across disease stages, the integration of immune-based therapies with standard targeted regimens, and emerging strategies to overcome resistance are particularly encouraged. By bridging clinical outcomes with molecular and immune characterization, this Special Issue aims to inform precision medicine approaches and guide the development of more effective, personalized therapeutic strategies for patients with breast cancer.
Dr. Saranya Chumsri
Dr. Hatem H. Soliman
Dr. Aixa Elena Soyano
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- targeted therapy
- immunotherapy
- biomarkers of response
- therapeutic resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
