Mechanisms of Lung Growth and Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 15 January 2026 | Viewed by 9
Special Issue Editors
Interests: lung development and regeneration/repair; fibroblast growth factors; epithelial stem cells; resident stromal niche; lipofibroblasts; fibrosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lung growth and regeneration are governed by epithelial–mesenchymal–vascular–immune cell interactions. The signaling pathways involved in lung growth are also recapitulated during regeneration following injury. This Special Issue will focus on understanding key cellular and molecular processes underlying lung growth and regeneration in the context of age, environment and species, with the hope of better understanding disease development; this constitutes the basis to establish novel regenerative approaches.
This Special Issue will highlight critical aspects of lung epithelial biology such as stem cells and regenerative medicine. The different epithelial stem/progenitor cells identified in the different regions of the lung interact with specific mesenchymal, immune and vascular niches that have recently been characterized. These niches dictate the quiescence of the epithelial stem/progenitor cells, their re-entry into the cell cycle and subsequent differentiation, as well as their regenerative potential. Emerging studies have shed light on the cells composing these different niches and their distinct roles in driving development, homeostasis, injury/repair and disease development
The biological distinctions between mesenchymal proliferation as a repair mechanism and fibrosis will also be of interest. Studies and reviews aiming to describe new tools in single-cell analysis, allowing a better understanding of lung development and regeneration, are welcomed. Research on the characterization of epithelial–mesenchymal interrelationships that maintain lung homeostasis and orchestrate growth and regeneration is also welcomed.
Prof. Dr. Saverio Bellusci
Prof. Dr. Yuanlin Song
Guest Editors
Manuscript Submission Information
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Keywords
- stem cells
- niche
- aging
- growth factors
- extracellular matrix
- organoids
- fibrosis
- single-cell RNAseq
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