Cellular and Molecular Mechanisms of Neurotoxicity

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 20 March 2026

Special Issue Editors


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Guest Editor
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
Interests: temporal lobe epilepsy; glia; astrocyte; microglia; connexin; neuroinflammation; cytokines; chicken imprinting

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Guest Editor
Department of Veterinary Anatomy, University of Jos, Jos, Nigeria
Interests: neuroanatomy

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Guest Editor
1. Department of Cell Biology, Physiology and Immunology, Faculty of Biology and Institute of Neurosciences, Universitat de Barcelona (UB), Barcelona, Spain
2. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED-CIBER), ISCIII, Madrid, Spain
Interests: syntaxin-1

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Guest Editor
Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
Interests: comparative anatomy; morphometrics; veterinary anatomy; embryology; gross anatomy; cross-sectional anatomy; neuro-therapy; neurodegeneration; neurotoxicology; immunohistochemistry

Special Issue Information

Dear Colleagues,

Neurotoxicity is a widespread condition as we are exposed to neurotoxic agents on a daily basis. Neurotoxins from external sources may be present in air pollutants, industrial chemicals, volatile gases, heavy metals, drugs, and other agents. Endogenous toxins can be produced through the altered metabolism of endogenous substances. The effects of toxins on the central and peripheral nervous system can lead to the degeneration and death of neuronal cells, and exposure to these substances has also been linked to the development of neurodegenerative diseases. This Special Issue will explore and provide a more comprehensive overview of the cellular and molecular mechanisms behind neurotoxicity and their connection to neurodegenerative conditions. The role of glial cells in neurotoxic mechanisms and the mechanisms by which neurotoxins cross or damage the blood–brain barrier are also of interest. Researchers are invited to contribute original research articles and reviews on the interactions of exogenous or endogenous neurotoxins with the nervous system, as well as their link to neurodegenerative diseases. Contributions highlighting disease models, human neuropathology, neuroinflammatory conditions, and cellular and molecular studies are welcome. This Special Issue does not intend to include articles analyzing clinical trials or focusing on therapeutic interventions.

Dr. Anna Andrioli
Dr. Idris Azeez
Dr. Tiziana Cotrufo
Dr. Mayowa Igado
Guest Editors

Manuscript Submission Information

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Keywords

  • neurotoxicity
  • neurodegeneration
  • neuronal cell death
  • neurodegenerative disorders
  • nerve regeneration
  • heavy metals
  • air pollution
  • endogenous neurotoxins
  • oxidative stress
  • glutamate

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Published Papers

This special issue is now open for submission.
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