Cellular and Molecular Mechanisms of Heart Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 208
Special Issue Editor
Interests: heart failure; molecular signaling; cardiovascular disease; therapeutic interventions; reduced ejection fraction; preserved ejection fraction; metabolic dysfunction; mitochondrial dysfunction; signal transduction; cardiac remodeling
Special Issue Information
Dear Colleagues,
Heart failure remains a global health burden, affecting an estimated 23 million individuals worldwide. Within this population, approximately half experience heart failure with reduced ejection fraction (HFrEF), while the other half suffer from heart failure with preserved ejection fraction (HFpEF). Both forms of heart failure present distinct challenges, with HFrEF being characterized by progressive left ventricular dilatation and adverse remodeling and HFpEF primarily involving diastolic dysfunction, ventricular stiffness, and impaired vasodilation.
In this Special Issue, we aim to bridge the gap between molecular signaling and therapeutic intervention in heart failure, focusing on both reduced and preserved ejection fraction. Recent advances in drug and device therapies have significantly altered the landscape of heart failure management, particularly in HFrEF, where foundational neurohormonal therapies have improved outcomes. In HFpEF, a more complex and heterogeneous pathophysiology presents unique challenges, including the stiffening of ventricular tissue, impaired chronotropic competence, and pulmonary hypertension.
We invite researchers to submit original research and review articles that explore the cellular and molecular mechanisms underlying heart failure, from gene expression and signaling pathways to translational therapeutic approaches. We encourage studies that focus on key areas such as fibrosis, inflammation, mitochondrial dysfunction, and metabolic dysregulation and how these insights can inform new treatment strategies for both HFrEF and HFpEF.
Dr. Sumita Mishra
Guest Editor
Manuscript Submission Information
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Keywords
- heart failure
- HFrEF
- HFpEF
- molecular signaling
- therapeutic interventions
- ejection fraction
- fibrosis
- metabolism
- mitochondrial dysfunction
- cardiovascular therapies
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