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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease

edited by

Alexander E. Berezin

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2055 | Submission Open

Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management

(This special issue belongs to the Section Tissues and Organs)

Drosophila as a Model for Understanding Human Disease

edited by Zhe Han

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1731 | Submission Open

Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research

(This special issue belongs to the Section Cellular Pathology)

Advances in Reproductive Biology: Cellular and Molecular Mechanisms

edited by

Rosa Roy

and Clara González-Marín

submission deadline 31 Mar 2026 | 3 articles | Viewed by 1625 | Submission Open

Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations

(This special issue belongs to the Section Reproductive Cells and Development)

Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex

edited by

Ángel A. Núñez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1254 | Submission Open

Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Insights into Vascular Physiology and Pathology

edited by Suravi Majumder

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1231 | Submission Open

Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches

(This special issue belongs to the Section Cellular Pathology)

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 756 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 691 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 393 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Insights into Allergies and Allergic Diseases

edited by

Toshiaki Kawakami

submission deadline 31 Mar 2026 | Viewed by 279 | Submission Open

Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Mar 2026 | Viewed by 241 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 216 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 215 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 187 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 147 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 143 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cells of the Nervous System)

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 117 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Hepatoblastoma: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: hepatoblastoma; APC; ARID1; β -catenin; hepatocellular carcinoma; hippo; YAP; pathogenesis; therapeutic strategies; molecular mechanisms

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

Cell Death and Apoptosis

edited by

Marianna Pap

and

Judit Varga

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms

(This special issue belongs to the Section Cellular Pathology)

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria

edited by Sonam Gurung

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)

Next-Generation CAR-T Cell Therapy: From Bench to Bedside

edited by

Ping Zhang

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models

(This special issue belongs to the Section Cellular Immunology)

Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies

edited by

Christoph Beisswenger

and Daniela Yildiz

submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open

Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing

Cellular and Molecular Mechanisms in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2026 | 1 articles | Viewed by 1233 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

and Shibo Wei

submission deadline 1 Apr 2026 | Viewed by 18 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 10 Apr 2026 | 4 articles | Viewed by 6156 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 10 Apr 2026 | 2 articles | Viewed by 5095 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cells of the Nervous System)

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 10 Apr 2026 | Viewed by 30 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 15 Apr 2026 | 5 articles | Viewed by 19004 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 15 Apr 2026 | 5 articles | Viewed by 8695 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cells of the Nervous System)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 15 Apr 2026 | 5 articles | Viewed by 7816 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 15 Apr 2026 | 3 articles | Viewed by 5046 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1595 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy

edited by

Siddharth Sunilkumar

, Stephanie L. Grillo and

Sandeep M. Subrahmanian

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1321 | Submission Open

Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy

(This special issue belongs to the Section Cellular Pathology)

Decoding Cancer Metabolism: Recent Insights and Future Directions

edited by Parash Prasad and Snehasis R. Mishra

submission deadline 15 Apr 2026 | Viewed by 426 | Submission Open

Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing

Gut Dysbiosis in Inflammatory Diseases

edited by Weiwei Liu

submission deadline 15 Apr 2026 | Viewed by 406 | Submission Open

Keywords: gut microbiota; innate and adaptive immunity; dysbiosis; metabolism; inflammatory bowel diseases; autoimmune diseases; metabolic disorders; fecal microbiota transplantation

(This special issue belongs to the Section Cellular Pathology)

Yeast Stress Responses and Cell Death Regulation

edited by

Maria João Sousa

Manuela Côrte-Real

and

Susana R. Chaves

submission deadline 15 Apr 2026 | Viewed by 384 | Submission Open

Keywords: yeast stress responses; environmental stresses; signalling pathways; cell death

Cell Biology of the Eye: Development, Disorders, and Repair

edited by

Meha Kabra

Praveen Joseph Susaimanickam

and

Alessandra Micera

submission deadline 15 Apr 2026 | Viewed by 121 | Submission Open

Keywords: eye development; ocular homeostasis; degenerative eye disorders; stem cells; Regenerative medicine; ocular imaging; disease modeling; cellular senescence; gene therapy; ophthalmology therapeutics

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease: A 2025 Update

edited by

Tommaso Neri

and

Erica Bazzan

submission deadline 15 Apr 2026 | Viewed by 108 | Submission Open

Keywords: extracellular vesicles (EVs); chronic obstructive pulmonary disease (COPD); inflammation; epithelial barrier; cellular senescence; tissue remodeling; biomarkers; exacerbations; microbiota; therapeutic targets

Advances in Annexin Biology

edited by

Raffaella Belvedere

Antonello Petrella

and Nunzia Novizio

submission deadline 15 Apr 2026 | Viewed by 99 | Submission Open

Keywords: annexin family; calcium-dependent membrane binding; cell signaling; inflammation and immune response; membrane repair; cancer biology; cell motility; cell differentiation; tumor microenvironment; diagnostic/prognostic biomarkers; therapeutic targets

Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases

edited by

Nikolaos Patikas

and Emmanouil Metzakopian

submission deadline 15 Apr 2026 | Viewed by 79 | Submission Open

Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction

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