Cellular and Molecular Basis of Brain Tumor
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 41
Special Issue Editors
Interests: brain tumor biology; molecular oncology; tumor microenvironment
Interests: molecular and genetic mechanisms of brain tumor progression; epigenetic regulation in central nervous system tumors
Interests: schwann cell biology and pathogenesis of vestibular schwannomas; tumor–nerve interface and cranial nerve preservation; radiosensitivity and molecular predictors of therapeutic response
Special Issue Information
Dear Colleagues,
Brain tumors represent a complex and heterogeneous group of malignancies with significant morbidity and mortality. Despite advances in neuroscience and oncology, the pathogenesis of brain tumors remains only partially understood and effective treatment strategies are limited. A comprehensive understanding of the cellular and molecular mechanisms underlying brain tumor initiation, progression, and resistance to therapy is crucial for the development of targeted interventions and improved patient outcomes.
We are pleased to invite you to contribute to this Special Issue, which aims to gather high-quality original research articles and reviews exploring the cellular and molecular basis of brain tumors. The scope encompasses, but is not limited to, the following: mechanisms of tumorigenesis, the tumor microenvironment, genetic and epigenetic alterations, tumor stem cells, and therapeutic resistance. This topic is directly aligned with the journal's focus on cell biology, molecular mechanisms, and translational biomedical research. We hope to attract a diverse array of contributions that reflect the multidimensional nature of brain tumor research.
Topics of interest include (but are not limited to) the following:
- Mechanistic insights into signaling pathways involved in gliomas and other primary brain neoplasms.
- Epigenetic modifications and genetic alterations driving tumor initiation and progression.
- Functional characterization and lineage dynamics of brain tumor-initiating cells.
- Crosstalk between tumor cells and the neural microenvironment, including immune and stromal interactions.
- Regulatory roles of non-coding RNAs in brain tumor biology.
- Emerging advances in molecular and genomic diagnostics for central nervous system tumors.
- Identification of novel therapeutic targets and mechanisms underlying treatment resistance.
- Development and validation of biomarkers for early detection, prognosis, and therapeutic response.
- Translational research using in vivo and in vitro preclinical models of brain tumors.
- Tumor heterogeneity and clonal evolution in brain neoplasms.
- Mechanisms of neuroinflammation and its role in brain tumor progression.
- Integration of multi-omics approaches for personalized medicine in neuro-oncology.
We look forward to receiving your valuable contributions.
Dr. Wojciech Czyżewski
Prof. Dr. Tomasz S. Mandat
Dr. Grzegorz Turek
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- brain tumor
- glioma
- tumor microenvironment
- molecular oncology
- epigenetics
- tumor stem cells
- biomarkers
- therapeutic resistance
- non-coding RNA
- translational research
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