Metabolic Regulation of Cell Behavior and Implications for Aging
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 November 2026 | Viewed by 381
Special Issue Editors
Interests: natural compounds; polyphenols; aging; cellular stress; proteostasis
Special Issues, Collections and Topics in MDPI journals
Interests: brain aging and neurodegeneration; intercellular communication; astrocyte metabolism; autophagy; reprogramming
Special Issue Information
Dear Colleagues,
Cellular metabolism is a central regulator of cell behavior, influencing processes such as proliferation, differentiation, senescence, and survival. Recent advances have revealed that metabolic pathways are not merely energy suppliers but active signaling hubs that shape cellular fate and function. Dysregulation of these pathways contributes to aging and age-related diseases, including neurodegeneration, cancer, immune and metabolic disorders. Understanding how nutrient availability, mitochondrial dynamics, and metabolic signaling interact with epigenetic and proteostatic mechanisms is essential to uncover novel strategies for promoting healthy aging and longevity.
This Special Issue aims to gather cutting-edge research and reviews on the role of metabolic regulation in cellular behavior and its implications for aging. Topics of interest include metabolic reprogramming, redox homeostasis, mitochondrial function, proteostasis, autophagy, and the interplay between metabolism and cellular stress responses (oxidative stress, glycative stress, etc.). We welcome studies using molecular, cellular, and systems biology approaches, as well as translational research exploring therapeutic interventions targeting metabolic pathways. By integrating insights from metabolism and aging biology, this Special Issue seeks to advance our understanding of how metabolic control can be leveraged to prevent or delay age-related functional decline.
Dr. Eloy Bejarano
Dr. José Antonio Rodríguez Navarro
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolism
- cellular aging
- senescence
- proteostasis
- oxidative stress
- glycation
- autophagy
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