Development and Characterization of Innovative In Vitro Models
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 May 2026 | Viewed by 11
Special Issue Editors
Interests: 3D organoids development; iPSC; iPSC reprograming; primary cell derivation; cell immortalization; diseases model development; stem cell therapy; molecular biology; cell signaling
Special Issue Information
Dear Colleagues,
The landscape of biological research is undergoing a transformative shift, driven by the urgent need for more predictive, ethical, and cost-effective models of human and animal biology. At the forefront of this evolution are in vitro systems, mimicking key physiological processes outside the organism. Given that the limitations of traditional models make them increasingly fall short in fully capturing complex biological responses, particularly in the context of human relevance and translational predictivity, the development and characterization of innovative in vitro models have become a cornerstone of modern life sciences.
This Special Issue, "Development and Characterization of Innovative In Vitro Models", brings together a diverse collection of studies showcasing the latest advances in the design, optimization, and application of innovative in vitro platforms. The Special Issue will publish full research articles and comprehensive reviews. Potential topics include, but are not limited to, the following research areas: development and characterization of novel 3D organoids from adult and iPSC cells, iPSC reprogramming, different primary cell derivations and cell immortalization from different tissues and species, disease model development, and stem cell therapy.
The Special Issue aims to span a broad range of biological systems and applications, offering valuable insights into how in vitro model systems are reshaping our approach to studying development, metabolism, disease progression, and therapeutic intervention. By fostering collaboration between biologists, engineers, automation, and AI, this Special Issue highlights the multidimensional innovation required to bring in vitro models from the bench to the real world.
We hope this Special Issue serves as a catalyst for continued advancement in this rapidly evolving field and inspires future research at the intersection of technology, biology, and translational science.
Dr. Fengyan Deng
Dr. Chongbei Zhao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- 3D organoid development
- iPSC
- iPSC reprogramming
- primary cell derivation
- cell immortalization
- disease model development
- stem cell therapy
- molecular biology
- cell signaling
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