Brain Function and Structure: Mapping Complexity in Neuronal Cells
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 May 2026 | Viewed by 1737
Special Issue Editor
2. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain
3. Institute of Neurosciences, University of Barcelona, 08028 Barcelona, Spain
Interests: brain organoids; neuronal activity; epilepsy; optogenetics; lab on chip; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the past few decades, technological advances have profoundly transformed our understanding of the nervous system, from its intricate structural organization to the dynamic interactions that sustain its function. The emergence of high-resolution imaging, single-cell transcriptomics, and computational modeling has unveiled new layers of complexity in neural networks and their cellular components. Among these, glial cells—once thought to play merely supportive roles—are now recognized as active participants in the regulation of neuronal signaling, plasticity, and brain homeostasis. In this issue, we aim to showcase how these technological innovations are reshaping the study of glial and neural function and the broader understanding of neural systems. We also highlight how biophysical factors, such as mechanical forces, ionic microenvironments, and metabolic coupling, can modulate both neuronal and glial activity, influencing communication and synchronization within neural circuits. Through state-of-the-art approaches, including advanced microscopy, optogenetics, and molecular profiling, researchers are uncovering how glia and neurons contribute to circuit dynamics in both physiological and pathological contexts. From astrocyte-neuron signaling to microglial modulation of synaptic networks, these discoveries underscore the intricate interplay between biological and physical mechanisms. Ultimately, such technical advances are redefining the boundaries of neuroscience and paving the way toward new therapeutic strategies for neural and glial dysfunctions.
Prof. Dr. José Antonio Del Río Fernández
Guest Editor
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Keywords
- optogenetics
- lab-on-chip platforms and brain organoids
- neuronal and glial networks
- neuromechanobiology
- system neuroscience
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