Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution

Dear Colleagues,

For this Special Issue, fundamental research endeavors to describe the molecular mechanisms driving breast cancer are warranted to ultimately develop tailored therapeutic options for this devastating disease. Recent advances in genomics and transcriptomics methodologies, such as single-cell RNA-seq and spatial transcriptomics and epigenomics, allow for the study of breast cancer cell subpopulations and their complex interactions at an unprecedented temporal and spatial resolution. The above could have important ramifications for identifying treatment-resistant populations as well as cancer cell vulnerabilities that could be precisely and effectively targeted.

We are pleased to invite you to contribute your research output towards elucidating the composition of subpopulations that constitute the complex breast tumor ecosystem, their transcriptional programs and interactions, and their responses and vulnerabilities to therapeutic regimes.

In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following: transcriptomics analysis of primary breast tumor samples or cell lines at the bulk, single-cell, or spatial transcriptomics level; studies including the analysis of DNA regulatory landscapes with technologies such as ATAC-seq and ChIP-seq; and, finally, alternative approaches, applying other “omics” methodologies such as proteomics and metabolomics that contribute to a holistic systems-level understanding of the tumor milieu.

We look forward to receiving your valuable contributions.

Prof. Dr. Angeliki Magklara
Dr. Spyros Foutadakis
Guest Editors

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