The Role of Ferroptosis in Cancer (2nd Edition)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 981
Special Issue Editor
2. Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, USA
Interests: hippo pathway; brain tumor; tumor microenvironment; ferroptosis; regulated cell death
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the previous one, entitled "The Role of Ferroptosis in Cancer" (https://www.mdpi.com/journal/cancers/special_issues/WXRJVATTG0).
Ferroptosis is a type of regulated cell death (RCD) that depends on iron and is caused by a lethal accumulation of intracellular lipid peroxides. Since it was discovered more than a decade ago, studies have found that tumor cells, while able to resist other types of therapy-induced cell death, such as apoptosis, are sensitive to ferroptosis. These different responses have led to research exploring the therapeutic benefit of eliminating tumor cells through ferroptosis. Accumulating evidence has emerged to support this notion. On the other hand, ferroptotic cells, through releasing damage-associated molecular patterns (DAMPs) or other metabolites, can alter the tumor microenvironment, especially immune cells. This effect could be associated with enhanced immunogenicity; however, in certain situations, it may lead to sustained inflammation and have an immunosuppressive impact, thereby promoting tumor progression and therapeutic resistance. Methods to exploit ferroptosis to benefit cancer therapy while circumventing the potential tumor promotion effect are under intense study.
This Special Issue will highlight the latest advances in basic and translational research of ferroptosis in cancer, aiming to accelerate the speed in exploiting ferroptosis for cancer treatment.
Dr. Wei Li
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ferroptosis
- cancer
- reactive oxygen species
- ROS
- regulated cell death
- RCD
- immunogenic cell death
- ICD
- immunosuppression
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