The Role of Ferroptosis in Cancer (2nd Edition)

Dear Colleagues,

This Special Issue is the second edition of the previous one, entitled "The Role of Ferroptosis in Cancer" (https://www.mdpi.com/journal/cancers/special_issues/WXRJVATTG0).

Ferroptosis is a type of regulated cell death (RCD) that depends on iron and is caused by a lethal accumulation of intracellular lipid peroxides. Since it was discovered more than a decade ago, studies have found that tumor cells, while able to resist other types of therapy-induced cell death, such as apoptosis, are sensitive to ferroptosis. These different responses have led to research exploring the therapeutic benefit of eliminating tumor cells through ferroptosis. Accumulating evidence has emerged to support this notion. On the other hand, ferroptotic cells, through releasing damage-associated molecular patterns (DAMPs) or other metabolites, can alter the tumor microenvironment, especially immune cells. This effect could be associated with enhanced immunogenicity; however, in certain situations, it may lead to sustained inflammation and have an immunosuppressive impact, thereby promoting tumor progression and therapeutic resistance. Methods to exploit ferroptosis to benefit cancer therapy while circumventing the potential tumor promotion effect are under intense study.

This Special Issue will highlight the latest advances in basic and translational research of ferroptosis in cancer, aiming to accelerate the speed in exploiting ferroptosis for cancer treatment.

Dr. Wei Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.