Role of TP53 Mutation in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 749
Editor
Interests: ovarian cancer; gene therapy; genome editing; adeno-associated virus; immune checkpoint
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor suppressor p53 is one of the most extensively studied proteins in cancer biology. Unlike many tumor suppressors that are inactivated by deletion or truncation, TP53 is most frequently altered by missense mutations, resulting in the expression of mutant p53 proteins with distinct biological properties. Accumulating evidence indicates that mutant p53 not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function activities that actively drive cancer initiation, progression, metastasis, and therapeutic resistance.
Recent advances have revealed that mutant p53 influences multiple cancer-related processes, including transcriptional reprogramming, chromatin remodeling, metabolic adaptation, genomic instability, and interactions with signaling pathways and the tumor microenvironment. Moreover, mutant p53 has emerged as a promising therapeutic target, with growing interest in strategies aimed at mutant p53 reactivation, degradation, synthetic lethality, and immunological targeting.
This Special Issue, “Role of TP53 Mutation in Cancer,” aims to provide a comprehensive platform for basic, translational, and clinical studies that deepen our understanding of mutant p53 biology and its implications across diverse cancer types. We welcome original research articles and high-quality reviews addressing molecular mechanisms, novel model systems, biomarker development, therapeutic vulnerabilities, and emerging clinical strategies targeting mutant p53. By integrating mechanistic insights with translational relevance, this Special Issue seeks to highlight how mutant p53 research can inform innovative approaches to cancer diagnosis and treatment.
Dr. Naoyuki Iwahashi
Guest Editor
Manuscript Submission Information
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Keywords
- TP53 mutation
- p53 aggregate
- gain-of-function
- cancer progression
- transcriptional reprogramming
- therapeutic targeting
- biomarker
- translational research
- precision oncology
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