The Molecular Mechanisms of DNA Replication and Repair
A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1228
Editor
Special Issue Information
Dear Colleagues,
DNA replication is a fundamental process that duplicates genetic material prior to cell division. It begins with the unwinding of the double helix, followed by the synthesis of complementary strands by DNA polymerase in accordance with the A-T and C-G base-pairing rules. This semi-conservative mechanism produces two identical DNA molecules, each containing one original and one newly synthesized strand, thereby ensuring genetic stability and faithful inheritance. However, DNA can be damaged by environmental factors or replication errors. To address this, cells employ various DNA repair mechanisms, such as base excision repair, nucleotide excision repair, and mismatch repair, to correct these mistakes. These processes recognize and remove damaged bases or mismatched pairs, thereby restoring the correct DNA sequence. In cancer, tumor cells obtain DNA damage due to replication stress and as a consequence of DNA damaging chemotherapies. Tumor cells rely on effective DNA repair mechanisms to avoid cell death and to sustain cell proliferation. Collectively, replication and repair mechanisms maintain genome integrity, prevent mutations, and support normal cellular function and survival, as well as contribute to tumor fitness and chemoresistance. This Special Issue, entitled "The Molecular Mechanisms of DNA Replication and Repair", invites submissions of research articles and review manuscripts on related topics.
Dr. Taru Muranen
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA replication
- DNA repair
- double helix
- drug resistance
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