Tumor Suppressor Genes and Oncogenes: Genome-Wide Insights into Cancer Biology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 56
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tumor suppressor genes (TSGs) play an important role in cancer progression. In healthy cells, they regulate essential processes such as cell cycle regulation, DNA damage repair and cellular differentiation. However, when mutated or dysregulated, they give rise to aberrant molecular processes in cancer cells. Therefore, understanding their functions in oncogenesis is crucial for establishing cancer prevention and treatment strategies. In cancers, TSGs are primarily silenced through mutations, deletions, DNA methylation, histone modifications and post-transcriptional regulation, resulting in deregulated cellular checkpoints, DNA repair and apoptosis, thereby promoting cancer development. Studies have also shown that TSGs can function in a cell-type-specific manner, with their activity tightly regulated by the epigenetic landscape, transcriptional networks, and microenvironmental signals unique to each tissue.
At the same time, oncogenes—when activated or amplified—drive uncontrolled cell proliferation, survival, and metastasis, acting as powerful tumor-promoting factors. Thus, the interplay between tumor suppressor genes and oncogenes represents a fundamental axis of cancer biology.
Genome analysis using next-generation sequencing techniques has revolutionized our understanding of cancer biology, allowing researchers not only to study the entire genetic landscape of cancer cells but also pave the way for personalized medicine, where treatments are tailored to the genetic profiles of individual patients’ tumors. Techniques such as whole-genome sequencing, exome sequencing, and RNA sequencing enable the identification of tumor suppressor gene alterations, discovery of novel cancer-associated mutations, and development of targeted therapeutic strategies.
In this Special Issue, we highlight the role of and mechanisms behind the regulation of TSGs in cancer, emphasizing genome-wide studies and the systematic characterization of tumor suppressor gene alterations that are essential for advancing cancer diagnostics, prognosis, and personalized treatment strategies.
Dr. Meena Kanduri
Guest Editor
Manuscript Submission Information
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Keywords
- tumor suppressor genes
- oncogenes
- cancer
- genome analysis
- cancer mutations
- DNA methylation
- histone modification
- cancer progression
- oncogenesis
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