Breast Cancer Evolution—Insights from Single-Cell Genomics
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 239
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast cancer is a highly heterogeneous disease shaped by dynamic evolutionary processes arising from intrinsic genomic instability, microenvironmental cues, and therapeutic intervention. Recent advances in single-cell genomics, including single-cell RNA-seq, ATAC-seq, multi-omics profiling, and spatially resolved technologies, allow unprecedented resolution of tumor ecosystems. These approaches reveal rare subclones, lineage plasticity, stromal–immune interactions, and early adaptive responses that drive treatment resistance and metastasis. This Special Issue highlights emerging insights into breast cancer evolution gained through single-cell technologies, spanning primary and metastatic disease, therapy resistance, immune microenvironment remodeling, and biomarker discovery. Together, these studies underscore the transformative potential of single-cell analysis to inform personalized therapy and guide next-generation clinical trials.
Prof. Dr. Cynthia Ma
Guest Editor
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Keywords
- single-cell genomics
- tumor evolution
- intratumoral heterogeneity
- lineage plasticity
- therapy resistance
- spatial transcriptomics
- tumor microenvironment
- clonal dynamics
- multi-omics profiling
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