HMGA Oncoproteins in Cancer

Introduction

High-Mobility Group A (HMGA) oncoproteins, including HMGA1 and HMGA2, play pivotal roles in chromatin architecture and transcriptional regulation. Their aberrant expression is a hallmark of numerous human cancers; they contribute to tumor initiation, progression, metastasis, and therapy resistance. Despite decades of research, recent advances continue to uncover unexpected aspects of HMGA biology and mechanisms of action, including their involvement in cancer stemness, metabolic rewiring, non-coding RNA networks, and tumor–microenvironment interactions.

Aim

We are pleased to invite you to contribute to the Special Issue “HMGA Oncoproteins in Cancer” in Cancers, which aims to gather cutting-edge research and comprehensive reviews to provide an updated and integrated view of the molecular, cellular, and clinical implications of these multifunctional architectural factors in cancer. By consolidating novel findings, emerging technologies, and translational perspectives, this collection will offer valuable insights into the mechanisms by which HMGA proteins drive tumorigenesis and how they may be exploited as diagnostic, prognostic, or therapeutic targets.

 Suggested themes

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• Regulation and function of HMGA1 and HMGA2 in cancer initiation and progression;
• HMGA-mediated chromatin remodeling and transcriptional reprogramming;
• Crosstalk between HMGA proteins and oncogenic signaling pathways;
• Role of HMGA proteins in epithelial–mesenchymal transition, stemness, and metastasis;
• Non-coding RNA networks (miRNAs, lncRNAs, circRNAs) regulating or regulated by HMGA;
• HMGA proteins as diagnostic, prognostic, or predictive biomarkers;
• Therapeutic strategies targeting HMGA expression or function;
• HMGA involvement in tumor microenvironment dynamics;
• Structural and biochemical aspects of HMGA–DNA or HMGA–protein interactions;
• Role of HMGA proteins in regulating mitotic division and self-renewal of stem cells.

Prof. Dr. Monica Fedele
Dr. Sabrina Battista
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.