Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 10 November 2025 | Viewed by 120
Special Issue Editors
Interests: gastrointestinal tumors; tumor suppressors; oncoproteins; metaplasia; tumor microenvironment
Special Issue Information
Dear Colleagues,
We are pleased to announce this Special Issue of Cancers, “Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy”.
Cancer, which is caused by uncontrolled, aberrant cell proliferation remains an important health issue worldwide. Understanding the distinct processes contributing to tumor formation and growth may provide a better foundation for future anticancer research. The first regulators of this biological process are proto-oncogenes, which function as growth factors by sending out signals. Mutations, gene amplification and chromosomal translocation are the activation processes of proto-oncogenes. Cancer cells develop due to changes in these sets of genes, causing mutations known as oncogenes. The resulting oncoproteins dysregulate cell proliferation, cell differentiation and other biological processes, leading to cancer. Tumors have been shown to exhibit angiogenesis and produce angiogenic factors that are activated by oncoproteins, which may be important for facilitating tumorigenesis. Additionally, the growth of tumors is closely linked to the prevention of programmed cell death, or apoptosis, which confers cell longevity. Recent advances in cancer research have identified new oncogenic molecules. However, the molecular mechanisms in the development of tumors are not well understood.
This Special Issue welcomes original research articles and reviews on the transcriptional regulation, signaling and therapeutic significance of oncoproteins in different cancer types.
We look forward to receiving your contributions.
Dr. Ravindran Caspa Gokulan
Prof. Dr. Francis Ali-Osman
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oncoproteins
- targeted therapy
- oncogenic signaling pathways
- tumor microenvironment
- oxidative stress and cancer
- tumorigenesis
- cancer chemoprevention
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