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Novel Genomic Strategies for Personalized Cancer Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 549

Special Issue Editors


E-Mail Website
Guest Editor
Belay Diagnostics, Chicago, IL 60607, USA
Interests: precision medicine; molecular diagnostics; viro-therapeutics
Institute for Cancer Research, Chinese Institutes for Medical Research, Beijing, China
Interests: DNA mismatch repair; genome instability; cancer; cancer immunotherapy; trinucleotide repeat instability; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

The era of one-size-fits-all cancer therapy is giving way to a precision oncology paradigm, driven by deep genomic characterization of individual tumors. Personalized cancer treatment utilizes genomic strategies to decipher the unique molecular blueprint of a patient's malignancy, identifying targetable alterations, prognostic signatures, and mechanisms of resistance. This approach integrates tools such as next-generation sequencing, liquid biopsies, and bioinformatic analyses to guide clinical decision-making. By matching specific genetic drivers with corresponding targeted therapies, these strategies maximize efficacy while minimizing exposure to ineffective treatments. Furthermore, genomic profiling enables the discovery of novel biomarkers, informs combination therapy regimens, and helps monitor clonal evolution during treatment. Ultimately, the integration of genomic data into clinical workflows is revolutionizing oncology, offering a more tailored, dynamic, and effective framework for patient care.

Dr. Honey Reddi
Dr. Guo-Min Li
Guest Editors

Manuscript Submission Information

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Keywords

  • precision medicine
  • assay validation
  • solid tumors
  • molecular methodologies
  • liquid biopsy

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Published Papers (1 paper)

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Research

20 pages, 1934 KB  
Article
Clinical Validation of the Belay Ascent™ Test to Report on Chromosomal Arm-Level Aneuploidy and Gene-Level Copy Number Variants in Cerebrospinal Fluid Using Low-Pass Whole-Genome Sequencing
by Qian Nie, Kala F. Schilter, Alexandra Larson, Vindhya Udhane, Viriya Keo, Sakshi Khurana, Jennifer N. Adams, Anthony Acevedo, Daniel Sanchez, Tarin Peltier, Kathleen Mitchell, DeElegant Robinson, Kyle M. Hernandez, Christopher Douville, Chetan Bettegowda and Honey V. Reddi
Cancers 2026, 18(8), 1277; https://doi.org/10.3390/cancers18081277 - 17 Apr 2026
Viewed by 296
Abstract
Background: Evaluation of chromosome aneuploidy and gene-level copy number alterations for diagnosis, prognosis, and therapeutic decision-making in solid tumors is the standard of care. Chromosomal microarray (CMA), next-generation sequencing (NGS), immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) are the gold standard for [...] Read more.
Background: Evaluation of chromosome aneuploidy and gene-level copy number alterations for diagnosis, prognosis, and therapeutic decision-making in solid tumors is the standard of care. Chromosomal microarray (CMA), next-generation sequencing (NGS), immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH) are the gold standard for detecting these variants in tumor tissue. In contrast to most solid tumors, cancers of the central nervous system (CNS) pose a unique challenge for effective detection via plasma due to the blood–brain barrier (BBB), with the additional challenges of brain biopsy or surgery being highly invasive and posing a significant risk to the patient. The Belay Ascent™ liquid biopsy test uses low-pass whole-genome sequencing (LP-WGS) to report on chromosome arm-level aneuploidy and gene-level copy number variants (CNVs) in cerebrospinal fluid (CSF) to inform diagnosis, prognosis, and therapeutic decision-making in CNS tumors. Methods: This study presents the equivalence of Ascent™ in detecting chromosome arm-level aneuploidy and gene-level CNVs using 48 tissue specimens followed by a clinical validation using a cohort of 32 CSF specimens with matched tissue-based tumor profiling information. Results: Equivalence of Ascent™ in detecting chromosome arm-level aneuploidy and gene-level CNVs using 48 tissue specimens was shown to have 100% and 97% positive percent agreement (PPA), respectively, compared to the gold standard of CMA/NGS. The validation cohort of 32 CSF specimens demonstrated 78% and 90% PPA for aneuploidy and gene-level CNVs, respectively. Clinical impact of Ascent™ was demonstrated, with 243 production cases able to inform the diagnosis and management of CNS tumors with high accuracy. Conclusions: Given the paucity of cells in CSF, limiting the use of karyotyping, CMA, IHC, and FISH, the Belay Ascent™ test provides a highly sensitive novel minimally invasive method for the evaluation of chromosome aneuploidy and gene-level CNVs in CSF. Full article
(This article belongs to the Special Issue Novel Genomic Strategies for Personalized Cancer Treatment)
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