The Molecular Biology of Cholangiocarcinoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 10
Special Issue Editors
Interests: cancer biology; transcription; gene regulation
Special Issue Information
Dear Colleagues,
Our understanding of the molecular biology of cancer of the bile duct, or cholangiocarcinoma (CCA), has advanced rapidly over the last 10-15 years. Molecular profiling has identified mutations that are prevalent in different CCA sub-types, including IDH1/2 mutations and FGFR2 rearrangements, and these allow some patients to receive targeted treatment. Analysis of the CCA tumour microenvironment (TME) has also been transformed by the application of new approaches including multiplex spatial analysis of gene and protein expression and single-cell sequencing. However, important issues remain, such as the lack of proven routes to early detection, the lack of freely accessible large-scale data sets, and patchy, or non-existent, patient access to molecular profiling.
We welcome primary research papers and reviews that focus on the cell and the molecular biology underlying these areas and related topics in cholangiocarcinoma research, and that thereby help to identify and close gaps in our knowledge of this disease.
Prof. Dr. Kevin Gaston
Prof. Dr. Padma-Sheela Jayaraman
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cholangiocarcinoma
- biliary tract cancer
- early detection
- targeted therapy
- tumour microenvironment
- spatial biology
- genomics
- transcriptomics
- proteomics
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