Mutagenesis and DNA Methylation in Aging
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 29
Special Issue Editor
Interests: bionanotechnology; epigenetics; EPS/prostate cancer; MSP/QPCR/TaqMan (Rotor-Gene); DNA sizing (agilent); HPLC; DNA synthesizer; spectrophotometry (nanodrop); clinical trials
Special Issue Information
Dear Colleagues,
The interactions between mutagenesis and DNA methylation are beginning to be appreciated. Those interactions are most apparent during mammalian aging where mutagenesis establishes genomic mosaicism from previously uniform genomes, leading at best to cell lineages with hindered functionality and excess cytopenia and at worst to tumorigenesis. Methylation patterns mirror these events not only because the tissue specific mosaic of methylation patterns established during development is directly altered by age-linked mutagenesis, but also because it is altered by the fidelity and integrity of the maintenance methylation systems.
This Special Issue seeks to provide an overview of the linkages between these two important genomic phenomena and their bearing on the fundamental nature of aging and carcinogenesis in mammals. Studies on interventions aimed at slowing or reversing these processes are of particular interest, as are original research studies on mammalian methylation clocks, mammalian repair systems, DNA methylation-linked DNA damage, and the comparative analysis of the systems and evolutionary processes that maintain the stability of the genome and the methylome.
Dr. Steven S. Smith
Guest Editor
Manuscript Submission Information
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Keywords
- genome structure evolution
- epigenetics
- aging
- tumorigenesis
- endogenous mutagenisis
- endogenous decay of methylation patterns
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