Castration- and Therapy-Resistant Prostate Cancer: Biomarkers, Therapeutic Targets, and Emerging Approaches
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 142
Special Issue Editor
Interests: castration-resistant prostate cancer (CRPC); extracellular vesicles; sex steroid hormones in cancers (breast, prostate, pancreatic and colon); triple negative breast cancer; sex steroid receptors; growth factor receptors signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although mortality from prostate cancer has decreased over recent decades, it remains the most frequently diagnosed malignancy among men worldwide. The major clinical challenge arises when prostate cancer progresses to a castration-resistant and aggressive form (CRPC), for which therapeutic options remain limited and largely non-curative.
In CRPC, androgen receptor (AR) signaling often persists despite androgen deprivation and continues to drive tumor progression. In addition to AR, multiple molecular players and alternative signaling pathways can cooperate with or bypass AR activity to sustain disease advancement. Several pathways, including EGFR-related signaling, have been shown to contribute to CRPC progression both in the presence and absence of AR expression.
To date, the identification of reliable biomarkers and actionable therapeutic targets represents a major priority for improving disease stratification, understanding resistance mechanisms, and developing innovative treatment strategies for this aggressive cancer subtype.
This Special Issue aims to provide an updated and comprehensive overview of recent advances in castration-resistant prostate cancer, encompassing the discovery of novel biomarkers, therapeutic targets, and emerging approaches for disease management. The Special Issue welcomes the contributions of original research articles and reviews addressing molecular mechanisms, signal transduction pathways, translational research, preclinical studies, and clinical perspectives.
Dr. Pia Giovannelli
Guest Editor
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Keywords
- castration-resistant prostate cancer
- therapy-resistant prostate cancer
- androgen receptor signaling
- EGFR-related signaling
- biomarkers
- drug resistance
- signal transduction pathways
- translational research
- targeted therapy
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