Host-Related Prognostic Factors in Gastrointestinal Malignancies: From Genetics to Phenomics
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 867
Special Issue Editors
Interests: esophagogastric cancer; surgical oncology; nutritional oncology; diagnostic imaging
Special Issue Information
Dear Colleagues,
In the era of personalized medicine, optimizing treatment outcomes for gastrointestinal malignancies requires a comprehensive assessment of not only tumor biology but also host-related factors.
Patient prognosis and treatment tolerance are deeply interconnected with individual characteristics, ranging from genetic background to phenotypic presentation.
This Special Issue aims to elucidate the clinical significance of these diverse host factors. We focus on the continuum of patient assessment: from genetic polymorphisms (e.g., drug-metabolizing enzymes like UGT1A1, DPYD, and MTHFR) that influence chemotherapy efficacy and toxicity, to phenotypic expressions such as host status defined by clinical examinations (e.g., body composition, sarcopenia, and cancer cachexia).
We welcome original clinical research and review articles addressing topics including, but not limited to, the following:
(1) Pharmacogenetics: Impact of germline variations on drug metabolism, adverse events, and survival.
(2) Body Composition Assessment: Clinical implications of sarcopenia, myosteatosis, and visceral adiposity evaluated by clinical modalities.
(3) Nutritional Oncology: Assessment of malnutrition, cachexia, and nutritional interventions.
(4) Systemic Inflammation: Host immune-inflammatory responses as prognostic markers.
(5) Therapeutic Management: Strategies to optimize host status for better chemotherapy tolerance and surgical outcomes.
By integrating findings from genetics to phenomics, this issue seeks to establish new standards for patient-centered management in GI cancers.
Dr. Kiyohiko Shuto
Dr. Yoshihiro Nabeya
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacogenetics
- body composition assessment
- nutritional oncology
- systemic inflammation
- therapeutic management
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