Cellular and Molecular Mechanisms of Medulloblastoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 1 October 2025 | Viewed by 51
Special Issue Editor
Special Issue Information
Dear Colleagues,
Medulloblastoma is a cancer of the central nervous system that commonly affects infants and children. Clinically, patients are classified into at least four subgroups based on epigenomic and transcriptomic profiles, genetics, and molecular pathological features. Clinical outcomes for patients with medulloblastoma are as diverse as the tumors themselves, with a near 100% survival rate for some subgroups as compared to a ~40% 5-year survival rate for others. Significant strides have been made over the last ten years to rigorously characterize these cancers, paving the way for the identification of new and improved therapies. However, given the complex and heterogeneous nature of medulloblastoma, more work is needed to close the survival gap.
This Special Issue aims to improve our understanding of medulloblastoma by combining contemporary research that illuminates current and emerging mechanisms of tumorigenesis, progression, maintenance, and treatment. Research on the cellular and molecular mechanisms of this cancer is the key to identifying novel therapeutic avenues to explore, making current therapies less toxic and with fewer side effects, and overcoming resistance associated with high-risk disease.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following range of topics relevant to medulloblastoma: diagnostic and prognostic marker identification, tumor microenvironment and heterogeneity, resistance mechanisms, targeted therapies, epigenetics, and fundamental biology related to the genetic risk factors associated with disease.
I look forward to receiving your contributions,
Dr. April Weissmiller
Guest Editor
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Keywords
- medulloblastoma diagnosis and prognostic markers
- WNT signaling
- SHH signaling
- MYC
- DNA methylation
- medulloblastoma treatment approaches and strategies (chemotherapy, radiation therapy, immunotherapy, and targeted therapy)
- high-risk medulloblastoma
- resistance mechanisms
- tumor microenvironment
- molecular characteristics of tumor heterogeneity
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