Cellular and Molecular Mechanisms of Malignant Nervous System Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 1 October 2025 | Viewed by 377
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cancers of the central and peripheral nervous system commonly affect children, adolescents, and young adults. While some may be benign and lead to favorable outcomes, others are aggressive, difficult to treat, and can lead to death. The majority of cancers that arise within the central nervous system are gliomas and medulloblastomas, while the most common extracranial nervous system cancer is neuroblastoma. Significant strides have been made over the last ten years to rigorously characterize these three nervous system cancers, paving the way for the identification of new and improved therapies. However, given the complex and heterogeneous nature of these malignancies, more work is needed to close the survival gap.
This Special Issue aims to improve our understanding of malignant nervous system cancers by combining contemporary research that illuminates current and emerging mechanisms of tumorigenesis, progression, maintenance, and treatment. Research on the cellular and molecular mechanisms of gliomas, medulloblastomas, and neuroblastomas is the key to identifying novel therapeutic avenues to explore, making current therapies less toxic and with fewer side effects, and overcoming resistance associated with high-risk diseases.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following range of topics relevant to malignant nervous system cancers: diagnostic and prognostic marker identification, tumor microenvironment and heterogeneity, resistance mechanisms, targeted therapies, epigenetics, and fundamental biology related to the genetic risk factors associated with the disease.
I look forward to receiving your contributions,
Dr. April Weissmiller
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- medulloblastoma
- pediatric glioma
- neuroblastoma
- diagnosis and prognostic markers
- IDH, TERT, and EGFR mutations
- DNA methylation
- treatment approaches and strategies (chemotherapy, radiation therapy, immunotherapy, and targeted therapy)
- resistance mechanisms
- tumor microenvironment
- molecular characteristics of tumor heterogeneity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
