BRCA1 and BRCA2 Pathogenic Variants: Cancer Risk and Genetic Testing
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 457
Editor
Interests: molecular biology and translational research of rare tumors; heredo-familial tumors; gene expression; molecular pathway network in solid tumors; cancer tumor microenvironment; tumor immunology; predictive and prognostic biomarkers in oncology; hereditary cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue on “BRCA1 and BRCA2 Pathogenic Variants: Cancer Risk and Genetic Testing.” These variants are well-established drivers of hereditary breast, ovarian, pancreatic, and prostate cancers. Advances in next-generation sequencing and molecular diagnostics have deepened our understanding of them, offering valuable opportunities for precision prevention and treatment. Genetic counseling and testing programs are becoming increasingly important for identifying at-risk individuals, guiding clinical decisions, and improving patient outcomes.
This Special Issue aims to provide a multidisciplinary overview of the role of BRCA1/2 variants in cancer susceptibility and management. We seek to highlight progress in molecular characterization, population-based screening, and targeted therapeutic approaches, including the use of PARP inhibitors. The collection will bring together contributions that bridge molecular research, clinical oncology, and genetic counseling, ensuring alignment with the Journal’s scope in cancer research and precision medicine.
We welcome original research articles and reviews. Topics may include (but are not limited to): functional characterization of BRCA1/2 variants, advances in genetic testing strategies, population-specific mutation prevalence, predictive models for cancer risk, targeted therapies, and ethical or psychosocial aspects of genetic testing.
We look forward to receiving your contributions.
Dr. Daniele Fanale
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- BRCA1
- BRCA2
- pathogenic variants
- hereditary cancer
- genetic testing
- PARP inhibitors
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