The Cellular Ecosystem of Cancer: New Insights into Cell Biology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 2640
Special Issue Editors
Interests: lung cancer; metastasis; EMT; Golgi apparatus; secretion; intracellular trafficking
Special Issue Information
Dear Colleagues,
Dysregulation of key cellular organelles—including the endoplasmic reticulum (ER), mitochondria, lysosomes, Golgi apparatus, and others—has emerged as a critical factor in cancer progression. Cancer cells actively remodel these organelles to sustain rapid proliferation and to reshape the tumor microenvironment.
Despite their fundamental importance, therapies directly targeting organelle function have achieved limited success. One major challenge lies in the fact that these organelles are also essential for normal cell survival. Therefore, an effective strategy requires identifying cancer-specific vulnerabilities—such as genetic alterations or hyperactivated pathways—that are indispensable for tumor cells but dispensable for normal tissues.
A deeper understanding of how cancer cells remodel organelle structure and function, and the key regulators involved in this process, will open new avenues for therapeutic intervention. This Special Issue will highlight recent advances in uncovering the diverse roles of cellular organelles in cancer biology and their potential as novel therapeutic targets.
Dr. Xiaochao Tan
Dr. Guan-Yu Xiao
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell organelle
- ER
- mitochondria
- lysosome
- Golgi
- secretion
- tumor microenvironment
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