Signaling Networks and Systems Biology in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 October 2026
Special Issue Editors
Interests: signal transduction; chimeric antigen receptor; CAR-M; CAR-T; cell therapy; immunotherapy; cell motility; chemotaxis
Special Issues, Collections and Topics in MDPI journals
Interests: cancer immunobiology; health disparity; drug discovery; precision oncology; nanotechnology; and chemokines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer progression is driven by highly dynamic and interconnected signaling networks that regulate cell growth, immune evasion, and therapy resistance. Advances in high-content imaging, multi-omics, and systems modeling now enable these pathways to be viewed as adaptive systems rather than linear cascades. This Special Issue invites submissions that explore how molecular signaling within and between cancer cells and their microenvironment influences tumor behavior and therapeutic outcomes. We welcome mechanistic, computational, and translational studies that reveal oncogenic signaling systems' organization and emergent properties. Topics of interest include systems biology and network medicine-based approaches to decipher tumor heterogeneity, metastasis, and immune modulation. Submissions highlighting artificial intelligence, immune cell engineering, and nanotechnology-based strategies to model, predict, or reprogram signaling dynamics are especially encouraged. Together, these studies will advance a systems-level understanding of cancer and guide the development of next-generation precision therapies.
Dr. Abhinava Mishra
Prof. Dr. Rajesh Singh
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer signaling
- immuno-oncology
- cancer nanotechnology
- AI/ML in cancer
- systems oncology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
