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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence (AI) in Biomedicine: 2nd Edition

edited by

Le Nguyen Quoc Khanh

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1524 | Submission Open

Keywords: bioinformatics and biomedical informatics; biomedical image processing; cancer genomics; data analysis and big data; data mining and text mining; e-Health machine learning and deep learning; molecular biology and medicine; natural language processing; single-cell sequencing analysis

(This special issue belongs to the Section Molecular Medicine)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 31 Jul 2025 | 2 articles | Viewed by 998 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jul 2025 | 1 articles | Viewed by 787 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 31 Jul 2025 | 1 articles | Viewed by 518 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Role of Glutathione Peroxidase in Health and Disease

edited by R Steve Esworthy

submission deadline 31 Jul 2025 | Viewed by 402 | Submission Open

Keywords: GPX1; GPX2; GPX3; GPX4; GPX5; GPX6; GPX7; GPX8; selenium; cancer; pathology

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production

edited by Pedro J. Real and

Laura Gutiérrez

submission deadline 31 Jul 2025 | Viewed by 389 | Submission Open

Keywords: megakaryocytes; platelets; omics; platelet disorders; inflammation

(This special issue belongs to the Section Cellular Biochemistry)

The Production and Destruction of Phytohormones by Microorganisms: Their Roles in the Promotion of Plant Growth and Resistance

edited by Guzel Kudoyarova

submission deadline 31 Jul 2025 | Viewed by 360 | Submission Open

Keywords: plant-growth-promoting bacteria (PGPB); mycorrhizae; auxins; cytokines; ethylene; abscisic acid; gibberellins; jasmonates; brassinolides; water relations; mineral nutrition; antioxidant system; protection against pathogens; salicylic acid; ethylene

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Novel Treatments of Stroke

edited by Saif Ahmad and Naseem Akhter

submission deadline 31 Jul 2025 | Viewed by 293 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Advances in Liver Transplantation and Hepatocellular Carcinoma

edited by

Paolo De Simone

submission deadline 31 Jul 2025 | Viewed by 292 | Submission Open

Keywords: biomolecular markers of liver graft quality; the prediction role of biomolecular markers in liver transplantation; biomolecular markers of graft viability in the setting of machine perfusion technology; biomolecular markers of liver graft dysfunction; HCC biomarkers: AFP; PIVKA; and SPIK; the role of inflammation and immunity; standards of biomolecular HCC diagnosis; biomolecular-based diagnostic algorithms for HCC; biomolecular-based screening and prevention algorithms; advantages and pitfalls of existing biomolecular diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Elucidating the Roles of Chromatin in Genomic Processes

edited by

Daniel M. Czajkowsky

and Meijun Liu

submission deadline 31 Jul 2025 | Viewed by 289 | Submission Open

Keywords: nucleosome positioning and occupancy; histone modifications; histone variants; nucleosome chaperones; nucleosome remodelers; insulator proteins; CTCF and cohesin; cis-regulatory elements; 3D genome structure; chromatin dynamics

Obesity-Related Diseases in Children: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Jul 2025 | Viewed by 285 | Submission Open

Keywords: childhood obesity; causes; therapy; epigenetics; biomolecules

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 31 Jul 2025 | Viewed by 284 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 31 Jul 2025 | Viewed by 267 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins

edited by

Fei Gao

submission deadline 31 Jul 2025 | Viewed by 221 | Submission Open

Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Digestive Enzymes in Health and Disease

edited by Stefan G. Pierzynowski, Kateryna Pierzynowska,

Piotr Wychowański

and

Janine Donaldson

submission deadline 31 Jul 2025 | Viewed by 212 | Submission Open

Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes

(This special issue belongs to the Section Enzymology)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Jul 2025 | Viewed by 209 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Organometallic Syntheses for Biomedical Applications

edited by Bala Krishna Moku

submission deadline 31 Jul 2025 | Viewed by 185 | Submission Open

Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies

edited by Ying-Hsi Lin and Shengjie Lu

submission deadline 31 Jul 2025 | Viewed by 173 | Submission Open

Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing

(This special issue belongs to the Section Molecular Medicine)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 31 Jul 2025 | Viewed by 171 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

Reactive Oxygen Species (ROS) Signaling in Response to Environmental Stressors

edited by Haoran Yu and

Samuel Dudley

submission deadline 31 Jul 2025 | Viewed by 165 | Submission Open

Keywords: ROS signaling; oxidative stress; mitochondrial function; environmental stressors; cellular signaling pathways; inflammation; toxicity endpoint; cell viability; gene expression; cytokine production

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 31 Jul 2025 | Viewed by 137 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Genomics and Molecular Biology of Solid Tumors

edited by Dragoş Creţoiu and Silviu Cristian Voinea

submission deadline 31 Jul 2025 | Viewed by 127 | Submission Open

Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy

(This special issue belongs to the Section Molecular Biology)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jul 2025 | Viewed by 118 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 31 Jul 2025 | Viewed by 114 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Genomic Insights into Microbial Infections

edited by

Weihua Huang

submission deadline 31 Jul 2025 | Viewed by 113 | Submission Open

Keywords: emerging pathogens; microbial evolution; pathogen– host interactions; infection prevention and treatment

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies

edited by

Livia Lenzini

and

Nicola Vitturi

submission deadline 31 Jul 2025 | Viewed by 74 | Submission Open

Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 31 Jul 2025 | Viewed by 34 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

Endothelial Health in Atherosclerosis: From Function to Dysfunction and Beyond

edited by

Yuqi Cui

and Zhenguo Liu

submission deadline 10 Aug 2025 | Viewed by 143 | Submission Open

Keywords: endothelial dysfunction; atherosclerosis; vascular inflammation; oxidative stress; nitric oxide signaling; cardiovascular biomarkers; endothelial repair; lipid metabolism; vascular homeostasis; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Circular RNAs: Functions, Applications and Prospects: 2nd Edition

edited by

William W. Du

and Feiya Li

submission deadline 15 Aug 2025 | 2 articles | Viewed by 4988 | Submission Open

Keywords: circular RNAs; circRNA; function; application; disease

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Inflammation—The Surprising Bridge between Diseases

edited by

Manuela Ciocoiu

Minerva Codruta Badescu

and

Iris Bararu-Bojan

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1846 | Submission Open

Keywords: low-grade inflammation; lung inflammation; atherosclerosis; ischemic heart disease; peripheral artery disease; inflammatory bowel disease; fatty liver disease; inflammatory rheumatic diseases; cancer

(This special issue belongs to the Section Molecular Biology)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 15 Aug 2025 | Viewed by 149 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

New Tissue Substitutes and Bioactive Materials and Their Responses in Clinical Use

edited by

Rodolfo Reda

submission deadline 15 Aug 2025 | Viewed by 104 | Submission Open

Keywords: new tissue substitutes; bioactive materials; cellular response

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

and Soraia Katia Pereira Costa

submission deadline 20 Aug 2025 | 1 articles | Viewed by 569 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Advances in Plasma Bioscience and Medicine: 2nd Edition

edited by

Yuantao Zhang

and

Maksudbek Yusupov

submission deadline 20 Aug 2025 | Viewed by 76 | Submission Open

Keywords: non-thermal (cold) atmospheric pressure plasma; reactive oxygen and nitrogen species (RONSs); plasma– biomolecule interactions; plasma cancer treatment; plasma immunomodulation; plasma inactivation of viruses; fungi and bacteria; plasma– liquid interactions; computer simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Biochemistry of Wine and Beer, 3rd Edition

edited by

Encarna Gómez-Plaza

and

Rocio Gil-Muñoz

submission deadline 30 Aug 2025 | 4 articles | Viewed by 3736 | Submission Open

Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds

(This special issue belongs to the Section Biological Factors)

Bioactive Molecules: Structures, Functions and Potential Uses for Cancer Prevention and Targeted Therapies (2nd Edition)

edited by

Qingping Dou

submission deadline 31 Aug 2025 | 8 articles | Viewed by 12488 | Submission Open

Keywords: small molecules; biomolecules; molecular targeting; natural products; cancer management

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 31 Aug 2025 | 5 articles | Viewed by 10037 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

State-of-the-Art of Myology 2024–2025

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 8371 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Aug 2025 | 5 articles | Viewed by 7290 | Submission Open

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Nanomaterials and Their Applications in Biomedicine

edited by

George Pasparakis

submission deadline 31 Aug 2025 | 4 articles | Viewed by 4942 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

Diabetic Retinopathy: From Pathophysiology to Therapeutic Perspectives

edited by Annayya R. Aroor,

Puttur Santhoshkumar

and Dean P. Hainsworth

submission deadline 31 Aug 2025 | 2 articles | Viewed by 4546 | Submission Open

Keywords: diabetic retinopathy; microvascular injury; neuronal dysfunction; mitochondrial dysfunction; oxidative stress; inflammation; biomarkers; signaling pathways; pharmacological interventions; anti-vegf; gene therapy; stem cell-based therapies; prevention strategies; patient education programs; patient-centered care

(This special issue belongs to the Section Molecular Medicine)

Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco

edited by Carlos A. Velázquez-Martínez and

Martín González-Andrade

submission deadline 31 Aug 2025 | 1 articles | Viewed by 4470 | Submission Open

Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Diet and Immune Response

edited by

Hanne Frøkiær

submission deadline 31 Aug 2025 | 3 articles | Viewed by 4277 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Intracerebral Hemorrhage: Advances in Preclinical Studies: 2nd Edition

edited by

Sangeetha Sukumari-Ramesh

submission deadline 31 Aug 2025 | 3 articles | Viewed by 3956 | Submission Open

Keywords: neuroinflammation; oxidative stress; neurodegeneration; neurological deficits; blood– brain barrier damage

(This special issue belongs to the Section Molecular Medicine)

The Role of CD36 in Human Health and Disease

edited by

Laura Cristina Ceafalan

and Mihail E. Hinescu

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2687 | Submission Open

Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker

(This special issue belongs to the Section Molecular Medicine)

The Role of Astrocytes in Neurodegenerative Diseases

edited by

Nima Sanadgol

submission deadline 31 Aug 2025 | 3 articles | Viewed by 2233 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

New Insights into RNA-Binding Proteins

edited by

Marko Noerenberg

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2113 | Submission Open

Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

and

Hyun-Woo Kim

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1986 | Submission Open

Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution

(This special issue belongs to the Section Molecular Genetics)

Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs

edited by Tatiana V. Lipina

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1973 | Submission Open

Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R; neurodevelopment; neurotransmission; synaptic plasticity; neural circuits; genomics; proteomics; intracellular signalling; bioenergetics; prevention

(This special issue belongs to the Section Molecular Biology)

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