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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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DNA Replication Stress Tolerance Mechanisms: From Nucleoside Analog Repair to Therapeutic Strategies

edited by

Kouji Hirota

and Ryotaro Kawasumi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: nucleoside analogs; DNA replication; DNA damage tolerance; DNA repair; DNA damage checkpoint; targeted cancer therapy

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms of Skeletal Muscle Growth and Loss in Health, Aging, and Disease

edited by

Khaled Kamal

submission deadline 31 Jul 2026 | Viewed by 593 | Submission Open

Keywords: skeletal muscle; muscle growth and atrophy; metabolic signaling (anabolic/catabolic); mechanotransduction; redox biology and oxidative stress; inflammation and immune signaling; obesity and metabolic disease; sarcopenia and aging; cachexia and neuromuscular disease; extracellular vesicles and exosomes

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jul 2026 | Viewed by 503 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

Molecular Biology and Therapy of Breast Cancer

edited by

Norbert Nass

submission deadline 31 Jul 2026 | Viewed by 390 | Submission Open

Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 31 Jul 2026 | Viewed by 338 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 31 Jul 2026 | Viewed by 338 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Therapeutics Targeting Pathogenic Mechanisms of Leishmaniasis

edited by

Kwang Poo Chang

submission deadline 31 Jul 2026 | Viewed by 288 | Submission Open

Keywords: leishmaniasis; host– parasite interactions; pathogenicity; precision medicine; AI-assisted development of therapeutics

Design and Applications of 3D Bioprinting

edited by

Saman Naghieh

and

Chaozong Liu

submission deadline 31 Jul 2026 | Viewed by 262 | Submission Open

Keywords: 3D bioprinting; biofabrication; tissue engineering; regenerative medicine; smart biomaterials; scaffold design; organ models; personalized therapeutics; biomedical additive manufacturing; translational bioprinting

(This special issue belongs to the Section Bio-Engineered Materials)

Tracking Aging and Stress: Omics-Based Insights into Physiology and Pathology

edited by

Dominika Drulis-Fajdasz

submission deadline 31 Jul 2026 | Viewed by 251 | Submission Open

Keywords: genetic proteomic; lipidomic metabolomic; aging senescence; neurodegeneration; cellular stress

(This special issue belongs to the Section Biological Factors)

Sterol Biosynthesis in Organisms

edited by Damjana Rozman and

Cene Skubic

submission deadline 31 Jul 2026 | Viewed by 244 | Submission Open

Keywords: sterol biosynthesis; sterol metabolism; sterol regulation; sterol-related diseases

(This special issue belongs to the Section Cellular Biochemistry)

Exploration of Drug Targets for Liver Fibrosis Based on Hepatic Stellate Cells and Extracellular Matrix Remodeling

edited by

Nadezda Apostolova

submission deadline 31 Jul 2026 | Viewed by 241 | Submission Open

Keywords: liver fibrosis; collagen; hepatic stellate cells; senescence; animal models; extracellular matrix; hepatitis; cytokines; biomarkers; MASH; MASLD; cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Medicine)

Hepatic Stellate Cells and Immune Microenvironment in Hepatocellular Carcinoma

edited by

Tai-long Pan

submission deadline 31 Jul 2026 | Viewed by 241 | Submission Open

Keywords: hepatic stellate cell; hepatocellular carcinoma; immune microenvironment; extracellular matrix; epigenetics; tumor microenvironment; inflammation

(This special issue belongs to the Section Molecular Medicine)

Mutagenesis and Genetic Instability in Genome Evolution and in Cancer: Mechanisms, Consequences, and Therapeutic Perspectives

edited by

Said Aoufouchi

and Rabii Ameziane El Hassani

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: genomic instability; mutagenesis; evolution; genetic diversification DNA repair; epigenetic; cancers; therapy resistance

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Autoimmune Diseases

edited by Ming-Lin Liu

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: autoimmune diseases; genetic and epigenetic; immune tolerance; T and B cell pathways; cytokines; molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Metabolic and Signaling Networks in Therapy Resistance

edited by

Jun He

and Lei Zhao

submission deadline 31 Jul 2026 | Viewed by 204 | Submission Open

Keywords: therapeutic resistance; metabolic reprogramming; systems biology; signaling networks

(This special issue belongs to the Section Molecular Medicine)

Protein Spreading in Neurodegenerative Diseases: From Mechanisms to Therapeutics

edited by

Xiaobo Mao

and

Enrico Moro

submission deadline 31 Jul 2026 | Viewed by 188 | Submission Open

Keywords: neurodegeneration; protein aggregation; Alzheimer disease; Lewy bodies; frontotemporal dementia

(This special issue belongs to the Section Molecular Medicine)

Significance of KEAP1 and NRF2 Protein-Protein Interactions in Cancer

edited by

Mihaela Matovina

submission deadline 31 Jul 2026 | Viewed by 166 | Submission Open

Keywords: cancer; protein– protein interactions (PPIs); KEAP1; NRF2

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Microbial Biocontrol and Plant-Microbe Interactions, 2nd Edition

edited by

Shahzad Munir

submission deadline 31 Jul 2026 | Viewed by 154 | Submission Open

Keywords: endophytic microbiome for disease management; plant– microbe interactions; microbial colonization for disease control; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response

(This special issue belongs to the Section Cellular Biochemistry)

Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors

edited by

Hewang Lee

and

Pedro A. José

submission deadline 14 Aug 2026 | 2 articles | Viewed by 1927 | Submission Open

Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain

The Role of Immune Cells in Human Arterial Diseases

edited by

Klaus Ley

submission deadline 14 Aug 2026 | Viewed by 174 | Submission Open

Keywords: carotid artery; endarterectomy; atherosclerosis; macrophage; lymphocytes; T cells; autoimmunity; smooth muscle cells; endothelial cells

(This special issue belongs to the Section Biological Factors)

From Target Antigens to Companion Diagnostics: Antibody-Based Therapies in Women’s Cancers

edited by

Salvatore Cortellino

and

Canio Martinelli

submission deadline 15 Aug 2026 | Viewed by 161 | Submission Open

Keywords: antibody– drug conjugate (ADC); antibody therapy; bispecific antibody; companion diagnostics; biomarker thresholds; immunohistochemistry; FRα ; HER2; tissue factor; spatial heterogeneity; tumor penetration; endocytosis/trafficking; bystander effect; resistance mechanisms

(This special issue belongs to the Section Molecular Reproduction)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 20 Aug 2026 | 3 articles | Viewed by 13606 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

submission deadline 20 Aug 2026 | 4 articles | Viewed by 4951 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 20 Aug 2026 | Viewed by 502 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 20 Aug 2026 | Viewed by 429 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

(This special issue belongs to the Section Chemical Biology)

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 20 Aug 2026 | Viewed by 347 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

edited by

Rui Li

and Xinmin Li

submission deadline 20 Aug 2026 | Viewed by 246 | Submission Open

Keywords: multiomics and bioinformatics; functional genomics; molecular breeding; molecular plant biology; functional genomics; sustainable agricultural biotechnology; nutrition and health of functional foods

(This special issue belongs to the Section Molecular Genetics)

Cellular and Molecular Mechanisms of Spermatogenesis, 2nd Edition

edited by YanHe Lue

submission deadline 20 Aug 2026 | Viewed by 210 | Submission Open

Keywords: spermatogenesis; regulation; biomolecules

(This special issue belongs to the Section Molecular Reproduction)

The Role of Non-Coding RNAs in Health and Disease: 2nd Edition

edited by

Narasimman Gurusamy

submission deadline 25 Aug 2026 | 2 articles | Viewed by 1649 | Submission Open

Keywords: non-coding RNA; ; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

Polysaccharides for Material Applications: From Plastics to Drug Carrier and Delivery Systems

edited by

Nicolas Joly

Patrick M. Martin

and

Vincent Sol

submission deadline 25 Aug 2026 | Viewed by 266 | Submission Open

Keywords: chemo/enzymatic modification; materials; plastics; composites; food applications; membranes; biomedical applications; biomaterials; drug delivery systems; nano carriers

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Extracellular Vesicles as Natural Nanocarriers: Advances in Cancer, Tissue Regeneration and Skin Health

edited by

Salvatore Panza

submission deadline 26 Aug 2026 | Viewed by 291 | Submission Open

Keywords: extracellular vesicles; natural nanocarriers; drug delivery; cancer therapy; regenerative medicine; skin health; dermocosmetics; tumor microenvironment; bioactive cargo; targeted delivery

Bioactive Compounds in Dermatology

edited by

Gaewon Nam

submission deadline 30 Aug 2026 | Viewed by 247 | Submission Open

Keywords: bioactive compounds; cosmetic active ingredients; dermatology; skin bioengineering; skin biology

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Molecular and Cellular Mechanisms in Multiple Sclerosis

edited by

Magdalena Zoledziewska

and Maria laura Idda

submission deadline 30 Aug 2026 | Viewed by 194 | Submission Open

Keywords: multiple sclerosis; gene expression; immunophenotyping; molecular-; expression- and protein-quantitative loci QTLs; non-coding RNAs; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Glycosylation: Cutting-Edge Approach to Targeted Therapy in Cancer

edited by

Myron R. Szewczuk

submission deadline 30 Aug 2026 | Viewed by 164 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 Aug 2026 | 11 articles | Viewed by 28570 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Aug 2026 | 5 articles | Viewed by 13051 | Submission Open

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Aug 2026 | 1 articles | Viewed by 12748 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

New Insights into Cardiometabolic Diseases, 2nd Edition

edited by

Gundu Rao

and

Undurti N. Das

submission deadline 31 Aug 2026 | 1 articles | Viewed by 9570 | Submission Open

Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events

(This special issue belongs to the Section Molecular Medicine)

New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition

edited by

Carola Yvette Förster

Mohsin Saleet Jafri

and Tarun W. Dasari

submission deadline 31 Aug 2026 | 3 articles | Viewed by 8102 | Submission Open

Keywords: brain– heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Aug 2026 | 2 articles | Viewed by 7234 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6432 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5949 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism

edited by

Katsuhiko Suzuki

and

Kayvan Khoramipour

submission deadline 31 Aug 2026 | 2 articles | Viewed by 5899 | Submission Open

Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation

(This special issue belongs to the Section Molecular Biology)

Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer

edited by Lynn Jeanette Savic

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5311 | Submission Open

Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages

(This special issue belongs to the Section Biological Factors)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3712 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3694 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3507 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2963 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2921 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

Iron Metabolism in Cells

edited by