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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins

edited by

Peter Pohl

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1453 | Submission Open

Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gökmen-Polar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1358 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1295 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds

edited by

Zhenming Yu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 699 | Submission Open

Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition

edited by

Bahman Anvari

submission deadline 31 Mar 2026 | Viewed by 583 | Submission Open

Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics

Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing

edited by

Kanhaiya Singh

submission deadline 31 Mar 2026 | 1 articles | Viewed by 526 | Submission Open

Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications

(This special issue belongs to the Section Molecular Genetics)

Molecular Advances in Stress Response, Growth, Development, and Breeding of Horticultural Crops

edited by

Bo Sun

Xin Li

and Jian Lyu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 522 | Submission Open

Keywords: horticultural crops; multi-omics integration; genome editing; molecular plant breeding; abiotic and biotic stress; quality; metabolic pathways; plant hormones; transcriptional and epigenetic regulation; protein interaction networks

(This special issue belongs to the Section Biological Factors)

Tissue-Specific Organelle Dynamics

edited by

Agnese De Mario

and

Marta Giacomello

submission deadline 31 Mar 2026 | Viewed by 359 | Submission Open

Keywords: organelles crosstalk; organelles contact sites; organelle dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 31 Mar 2026 | Viewed by 251 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Mar 2026 | Viewed by 229 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement

edited by

Franziska Roth-Walter

and

Carolina Frizzo-Ramos

submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open

Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance

Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential

edited by Umesh Kumar Jinwal

submission deadline 31 Mar 2026 | Viewed by 187 | Submission Open

Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Mar 2026 | Viewed by 170 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation

edited by

Gabriele La Monica

and

Antonino Lauria

submission deadline 31 Mar 2026 | Viewed by 160 | Submission Open

Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets

Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior

edited by

Marco Dal Maschio

Nicola Facchinello

and

Maria Elena Miletto Petrazzini

submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open

Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration

(This special issue belongs to the Section Chemical Biology)

The Role of Heparin in Blood

edited by

Viktoria Weber

Stephan Harm

and Denisa Cont

submission deadline 31 Mar 2026 | Viewed by 132 | Submission Open

Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)

(This special issue belongs to the Section Molecular Medicine)

Structure, Molecular Dynamics, Assembly, and Evolution of Protein Systems with AI-Enhanced Modeling in Pharmacology and Structural Biology

edited by

Michal Blazej Ponczek

and

Mohamed Ragab AbdelGawwad

submission deadline 31 Mar 2026 | Viewed by 130 | Submission Open

Keywords: machine learning in structural biology; molecular dynamics simulations; protein– ligand interactions; computational pharmacology; structure-based drug design

(This special issue belongs to the Section Molecular Biology)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: obesity; causes; therapy; epigenetics; biomolecules

Post-Translational Modifications in Disease: From Computational Prediction to Functional Mechanisms

edited by

Mengsha Tong

submission deadline 31 Mar 2026 | Viewed by 123 | Submission Open

Keywords: post-translational modifications; PTMs; disease

Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

Fabrice Antigny

and Grégoire Ruffenach

submission deadline 31 Mar 2026 | Viewed by 116 | Submission Open

Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches

(This special issue belongs to the Section Molecular Medicine)

Amino Acids and Their Metabolism in Disease

edited by

Toshiyuki Kitoh

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by

Yoshikazu Takada

submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open

Keywords: integrin; fibronectin; cytokines

(This special issue belongs to the Section Chemical Biology)

Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy

edited by

Takeyori Saheki

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: citrin deficiency; pathogenesis; therapeutic procedures

(This special issue belongs to the Section Molecular Medicine)

Choline and Its Supplementation in Human Health and Disease

edited by

Francesco Amenta

and Enea Traini

submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open

Keywords: choline; transporters; deficiencies; supplementations

(This special issue belongs to the Section Molecular Medicine)

From Molecular Mechanisms to Therapies: Advances in Retinal Disease Research

edited by

Marco Feligioni

and

Maccarone Rita

submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open

Keywords: retinal diseases; retinal pathologies; preclinical studies

(This special issue belongs to the Section Molecular Biology)

Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases

edited by

Dario Mizrachi

submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open

Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia

edited by

Yong-Mi Kim

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial Calcium Signaling in Cardiac Health and Disease

edited by Enrique Balderas

submission deadline 2 Apr 2026 | Viewed by 78 | Submission Open

Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance

(This special issue belongs to the Section Cellular Biochemistry)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 3 Apr 2026 | 1 articles | Viewed by 1561 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 15 Apr 2026 | 1 articles | Viewed by 6307 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles as Biomarkers of Diseases: 2nd Edition

edited by

Mebarek Saida

and

Leyre Brizuela

submission deadline 15 Apr 2026 | Viewed by 30 | Submission Open

Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 20 Apr 2026 | 7 articles | Viewed by 26702 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy

edited by

Célia Duarte Cruz

and

José Tiago Costa-Pereira

submission deadline 20 Apr 2026 | Viewed by 116 | Submission Open

Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition

edited by Peng Yao and

Wei Guo

submission deadline 20 Apr 2026 | Viewed by 45 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 25 Apr 2026 | 3 articles | Viewed by 3303 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Apr 2026 | 6 articles | Viewed by 14672 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Advances in Melanoma Targeted Therapy

edited by

Dmitriy Minond

submission deadline 30 Apr 2026 | 3 articles | Viewed by 10237 | Submission Open

Keywords: melanoma; drug discovery; new targets; target discovery

(This special issue belongs to the Section Molecular Medicine)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 30 Apr 2026 | 4 articles | Viewed by 8629 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 30 Apr 2026 | 2 articles | Viewed by 7187 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 30 Apr 2026 | 2 articles | Viewed by 7057 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

and

Laura Hamilton

submission deadline 30 Apr 2026 | 5 articles | Viewed by 6372 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Genetics and Epigenetics of Breast Cancer

edited by

Ashakumary Lakshmikuttyamma

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6123 | Submission Open

Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers

(This special issue belongs to the Section Molecular Genetics)

Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets

edited by

S. Priya Narayanan

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5378 | Submission Open

Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Biomarkers)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5352 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Therapeutic Targets in Leukaemia

edited by

Sabrina Tosi

and

Denise Ragusa

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5121 | Submission Open

Keywords: leukaemia; blood; genetics; genomics; chromosome

(This special issue belongs to the Section Molecular Medicine)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4427 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

and

Hyun-Woo Kim

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3812 | Submission Open

Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3433 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 30 Apr 2026 | 4 articles | Viewed by 3419 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

(This special issue belongs to the Section Natural and Bio-derived Molecules)

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