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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Properties and Functions of Endometrial Stromal Cells

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3315 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

New Insights into Neuroimmunology

edited by

Marc André Lécuyer

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3235 | Submission Open

Keywords: neuroimmunology (in health and disease); multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); acute disseminated encephalomyelitis (ADEM); neuromyelitis optica spectrum disorders (NMOSD); transverse myelitis; anti-NMDA receptor encephalitis (NMDAR encephalitis); paraneoplastic autoimmune diseases; neurodegenerative diseases with immunological components; Parkinson’ s disease; Alzheimer’ s disease; neuroinfections

(This special issue belongs to the Section Cellular Biochemistry)

Tumor Microenvironment, Immunology and Precision Medicine of Liver Cancer

edited by Lynn Jeanette Savic

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3167 | Submission Open

Keywords: hepatocellular carcinoma; hypoxia; tumor microenvironment; immunometabolic crosstalk; tumor-associated macrophages

(This special issue belongs to the Section Biological Factors)

Mass Spectrometry Imaging in Neuroscience

edited by Nhu Thi Ngoc Phan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3153 | Submission Open

Keywords: mass spectrometry imaging; secondary ion mass spectrometry (SIMS); matrix-assisted laser desorption/ionization (MALDI); desorption electrospray ionization (DESI); laser ablation– inductively coupled plasma– mass spectrometry imaging (LA-ICP-MSI); multi-isotope imaging mass spectrometry (MIMS); molecular and organelle turnover; brain; neurons; synapses; neuronal stem cells; membrane lipids; synaptic proteins; neural peptides; metabolites; diseases; disorders

(This special issue belongs to the Section Molecular Medicine)

Mechanisms of Kidney Injury and Treatment Modalities

edited by Utpal Sen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2833 | Submission Open

Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Cellular and Non-Cellular Treatment of Stroke

edited by

David T. Harris

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2391 | Submission Open

Keywords: stroke; treatment; therapy; biomolecules; stem cells

(This special issue belongs to the Section Molecular Medicine)

Advances in Cancer and Glycosylation

edited by

Myron R. Szewczuk

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2375 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

edited by

Mykola Mamenko

and Brandi M. Wynne

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2305 | Submission Open

Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2236 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Recent Developments in the Biology of Extracellular or Cell-Free DNA, 2nd Edition

edited by

Peter Celec

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1732 | Submission Open

Keywords: neutrophil extracellular traps; DNase; toll-like receptor 9; exosomes; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Pluripotent Stem Cell Models of Human Disease

edited by Satish Kumar

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1693 | Submission Open

Keywords: pluripotent stem cells; cellular reprogramming; cellular differentiation; 2D and 3D cell models of human disease; cellular phenotypes; biomarkers; disease gene; multi-omics approaches; genome editing; drug screening and discovery

(This special issue belongs to the Section Cellular Biochemistry)

Metabolic Inflammation and Insulin Resistance in Obesity

edited by Bingxian Xie

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1415 | Submission Open

Keywords: obesity-linked inflammation; insulin resistance; adipose tissue

(This special issue belongs to the Section Lipids)

Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases

edited by Aurora Daniele and

Ersilia Nigro

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1361 | Submission Open

Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease

(This special issue belongs to the Section Biological Factors)

Biomolecules and Materials from Agro-Industrial Wastes, 2nd Edition

edited by

Valdir Florencio Da Veiga Junior

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1309 | Submission Open

Keywords: bioactive molecules from discarded plant parts; new extraction methodologies; green solvents; green chemistry; bioenergy; biorefinery; biofibres

(This special issue belongs to the Section Bio-Engineered Materials)

Protein Self-Assembly in Diseases and Function

edited by

Anoop Arunagiri

, Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1102 | Submission Open

Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Defects in the Transport Mechanism of Membrane Proteins and Related Diseases, 2nd Edition

edited by Daniela Valeria Miniero

submission deadline 30 Nov 2025 | 1 articles | Viewed by 734 | Submission Open

Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Retroviruses and Endogenous Retroviruses (ERVs) in Mammalian Placenta and Beyond 2025

edited by

Kazuhiko Imakawa

and

Jun Sugimoto

submission deadline 30 Nov 2025 | 1 articles | Viewed by 733 | Submission Open

Keywords: retroviruses; ERVs (endogenous retroviruses); placental diversity; organ development (stem cells); immunoregulation

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

Antioxidant and Anti-Inflammatory Activities of Phytochemicals

edited by

Peter Rose

and

Yi Zhun Zhu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 705 | Submission Open

Keywords: antioxidants; plant bioactives; inflammation; free radicals

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 30 Nov 2025 | 1 articles | Viewed by 617 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

Acute Kidney Injury and Mitochondrial Involvement

edited by

Iva Suman

submission deadline 30 Nov 2025 | 1 articles | Viewed by 511 | Submission Open

Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers

(This special issue belongs to the Section Chemical Biology)

New Insights into Cardiometabolic Diseases, 2nd Edition

edited by

Gundu H. R. Rao

and

Undurti N. Das

submission deadline 30 Nov 2025 | Viewed by 465 | Submission Open

Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production

edited by Pedro J. Real and

Laura Gutiérrez

submission deadline 30 Nov 2025 | Viewed by 440 | Submission Open

Keywords: megakaryocytes; platelets; omics; platelet disorders; inflammation

(This special issue belongs to the Section Cellular Biochemistry)

Thyroid Cancer: Molecular Mechanisms and Targeted Therapies

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

and

Horaţiu Silaghi

submission deadline 30 Nov 2025 | Viewed by 314 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; molecular biomarkers; oncogenic signaling pathways; thyroid cytology; targeted therapy; tyrosine kinase inhibitors; immune checkpoint inhibitors; therapeutic strategies; thyroid cancer prognosis; epigenomics in thyroid cancer

(This special issue belongs to the Section Molecular Medicine)

Advances in Nano-Based Drug Delivery Systems

edited by

Amalendu P. Ranjan

Nirupama A. Sabnis

and

Zacharias Suntres

submission deadline 30 Nov 2025 | Viewed by 230 | Submission Open

Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules

(This special issue belongs to the Section Molecular Medicine)

Industrial Microorganisms and Enzyme Technologies

edited by

Yunjun Yan

submission deadline 30 Nov 2025 | Viewed by 183 | Submission Open

Keywords: enzyme engineering; enzyme kinetics and optimization; industrial biotechnology; industrial microbiology; microbial metabolism

(This special issue belongs to the Section Enzymology)

Advances in Molecular Mechanisms in Chronic Kidney Disease

edited by

Francisco Herrera-Gómez

and María J. Izquierdo

submission deadline 30 Nov 2025 | Viewed by 173 | Submission Open

Keywords: chronic kidney disease; end-stage kidney disease; etiological diagnosis; biomarkers; personalized medicine; humans

(This special issue belongs to the Section Molecular Biomarkers)

New Insight into the Structures and Host Cell Interactions of Emerging Viruses

edited by

Wei Zhang

and

Qibin Geng

submission deadline 30 Nov 2025 | Viewed by 168 | Submission Open

Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Genetic Insights into Biological Mechanisms Governing Aging

edited by

Zhihong Yang

and Duilio Michele Potenza

submission deadline 30 Nov 2025 | Viewed by 159 | Submission Open

Keywords: aging; genetics; cellular senescence; oxidative stress; inflammation; mitochondrial function

(This special issue belongs to the Section Molecular Genetics)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanisms of Olfactory and Gustatory System

edited by

Andrea Mazzatenta

submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open

Keywords: olfaction; smell; taste; chemical stimuli; sensation; perception; Volabolome; advanced diagnostic techniques

(This special issue belongs to the Section Molecular Biology)

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 30 Nov 2025 | Viewed by 118 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

Deciphering Biomolecular Multimeric Systems: Computational Advances in Structure, Dynamics, and Function

edited by

Zhaoxi Sun

, Jinping Lei and Hui Wang

submission deadline 30 Nov 2025 | Viewed by 115 | Submission Open

Keywords: molecular glue; molecular simulations; PROTAC; binding affinity; binding mode; MSM; membrane

Multiple Sclerosis Pathogenesis: Bridging Innate and Adaptive Immunity

edited by Jo Anne Stratton and Stephanie Zandee

submission deadline 30 Nov 2025 | Viewed by 110 | Submission Open

Keywords: multiple sclerosis; innate– adaptive immune crosstalk; glial biology and complement; cellular immunology; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Cancer Biology: Machine Learning and Bioinformatics

edited by Annalisa Santucci,

Ottavia Spiga

and

Anna Visibelli

submission deadline 30 Nov 2025 | Viewed by 105 | Submission Open

Keywords: cancer biology; bioinformatics; machine learning; big data

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Type 2 Diabetes: Molecular Mechanisms and Therapeutic Innovations

edited by Orien L. Tulp

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: type 2 diabetes (T2DM); insulin resistance; GLUT4; sirtuins; epigenetic expression; nutrition; pharmacotherapeutics

(This special issue belongs to the Section Molecular Medicine)

New Insights into Stem Cell-Derived Exosomes in Human Health and Disease

edited by

Lubos Danisovic

submission deadline 30 Nov 2025 | 1 articles | Viewed by 73 | Submission Open

Keywords: stem cells; exosomes; regenerative medicine; diagnostics

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial Dysfunction: Mechanisms and Advances

edited by

Jose Manuel Rodriguez-Vargas

submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open

Keywords: mitochondrial disease; neurological disorders; cancer; targeted therapy

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Genetic and Epigenetic Basis of Schizophrenia

edited by

Inna Gaisler-Salomon

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: schizophrenia; epigenetics; animal models; methylation; microRNA; gene-environment interactions

(This special issue belongs to the Section Molecular Genetics)

Bacterial Molecular Biology: Stress Responses and Adaptation

edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa

submission deadline 30 Nov 2025 | Viewed by 2 | Submission Open

Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks

(This special issue belongs to the Section Molecular Biology)

Lipid Signaling in Human Disease

edited by Berit Johansen and Felicity Ashcroft

submission deadline 10 Dec 2025 | Viewed by 85 | Submission Open

Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids

(This special issue belongs to the Section Lipids)

Mechanisms and Kinetics of Interactions of Biomolecules at Interfaces: 2nd Edition

edited by

Monika Wasilewska

Aneta Michna

and

Maria Morga

submission deadline 15 Dec 2025 | 4 articles | Viewed by 13105 | Submission Open

Keywords: biomolecule adsorption; kinetics of biomolecule adsorption; mechanisms of biomolecule deposition; interactions of biomolecules; techniques for the detection of biomolecules at solid substrates; interactions of proteins with biomolecules/biopolymers; protein and biomolecule systems; protein and biomolecule complexes

(This special issue belongs to the Section Bio-Engineered Materials)

Antibiotic Resistance Mechanisms and Their Potential Solutions

edited by Sung-Pin Tseng,

Cheng Yen Kao

and

Tsung-Ying Yang

submission deadline 15 Dec 2025 | 4 articles | Viewed by 11378 | Submission Open

Keywords: antibiotic resistance; antimicrobial development; molecular mechanism; priority for antibiotics; newly therapeutic approach

(This special issue belongs to the Section Molecular Biology)

Role of Neuroactive Steroids in Health and Disease: 2nd Edition

edited by

Roberto Cosimo Melcangi

submission deadline 15 Dec 2025 | 7 articles | Viewed by 9388 | Submission Open

Keywords: neurosteroids; neurodegenerative disorders; psychiatric disorders; physiological effects

(This special issue belongs to the Section Molecular Biology)

Role of TRAF in Regulating Inflammation and Cell Survival

edited by Ali Abdul-Sater

submission deadline 15 Dec 2025 | 2 articles | Viewed by 4396 | Submission Open

Keywords: TRAF; inflammation; inflammasome; TNFRs; apoptosis; cellular survival

(This special issue belongs to the Section Biological Factors)

New Insights into Cardiovascular Immunology

edited by Susanne Sattler, Pilar Martín and Stephen Malin

submission deadline 15 Dec 2025 | 1 articles | Viewed by 4119 | Submission Open

Keywords: inflammation; autoimmunity; atherosclerosis; myocarditis; heart failure

(This special issue belongs to the Section Molecular Medicine)

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1112 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Epstein-Barr Virus Disease Mechanisms and Stress Responses: 2nd Edition

edited by

Marshall Vance Williams

submission deadline 15 Dec 2025 | Viewed by 558 | Submission Open

Keywords: Epstein– Barr virus (EBV); reactivation; immune modulation; stress; aging

(This special issue belongs to the Section Molecular Medicine)

Novel Insights on Cancer Stem Cells

edited by