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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 10 May 2025 | 5 articles | Viewed by 7832 | Submission Open

Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’ s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; SARS-CoV-2; spike protein; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics

(This special issue belongs to the Section Chemical Biology)

Cellular and Molecular Mechanism of Spermatogenesis

edited by Yanhe Lue

submission deadline 10 May 2025 | 3 articles | Viewed by 5068 | Submission Open

Keywords: spermatogenesis; regulation; biomolecules

(This special issue belongs to the Section Molecular Reproduction)

Protein Structure Prediction in Drug Discovery: 2nd Edition

edited by

Alessandro Paiardini

submission deadline 15 May 2025 | 5 articles | Viewed by 22284 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Skeletal Muscle Homeostasis and Regeneration

edited by

Ernö Zádor

submission deadline 15 May 2025 | 6 articles | Viewed by 15742 | Submission Open

Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type

(This special issue belongs to the Section Molecular Medicine)

Interface of Aging and Biomaterials: 2nd Edition

edited by

Joshua T. Morgan

submission deadline 15 May 2025 | 3 articles | Viewed by 10075 | Submission Open

Keywords: aging; senescence; geroscience; biomolecules; biomaterials; biocompatibility; nanoparticles; hydrogels

(This special issue belongs to the Section Bio-Engineered Materials)

Role of Matrix Metalloproteinase in Health and Disease

edited by Ali A. Hussain

submission deadline 15 May 2025 | 3 articles | Viewed by 2859 | Submission Open

Keywords: matrix metalloproteinases (MMPs); regulatory aspects of MMPs; MMPs and tissue ageing; MMPs in diseases; MMPs as therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

The Role of Arginine and Arginine Metabolites in Cerebro- and Cardiovascular Disease Targeted Therapy

edited by Edzard Schwedhelm,

Arduino A. Mangoni

, Roman N. Rodionov and Ying Wang

submission deadline 15 May 2025 | 1 articles | Viewed by 2658 | Submission Open

Keywords: alanine:glyoxylate aminotransferase 2; asymmetric dimethylarginine; cyclic guanosine monophosphate; dimethylarginine dimythylaminohydrolase 1; homoarginine; nitric oxide; symmetric dimethylarginine

(This special issue belongs to the Section Molecular Medicine)

Novel Biomarkers of Kidney Diseases: Second Edition

edited by

Vladimír Tesař

and

Dita Maixnerova

submission deadline 15 May 2025 | 1 articles | Viewed by 1619 | Submission Open

Keywords: biomarker; kidney disease; fibrosis; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biomarkers)

Recent Developments in Biophysical Studies of Cell Membranes: Second Edition

edited by

William T. Heller

submission deadline 20 May 2025 | 3 articles | Viewed by 2761 | Submission Open

Keywords: membrane biophysics; cell membranes; model cell membranes

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Tumour Suppressor Genes: The Guardians of Cell Integrity

edited by

Nicola Manfrini

submission deadline 20 May 2025 | 1 articles | Viewed by 1182 | Submission Open

Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy

(This special issue belongs to the Section Molecular Biology)

Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition

edited by

Shinji Sakai

submission deadline 21 May 2025 | 2 articles | Viewed by 2022 | Submission Open

Keywords: tissue engineering; bioactive molecules; cellular function; proliferation

(This special issue belongs to the Section Bio-Engineered Materials)

Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond

edited by

Stefano Pascarella

submission deadline 30 May 2025 | 4 articles | Viewed by 4071 | Submission Open

Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advances in Neuroproteomics

edited by

Kenneth R. Williams

and

Angus C. Nairn

submission deadline 31 May 2025 | 8 articles | Viewed by 21706 | Submission Open

Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Cancer Immunotherapy and the PD-1/PD-L1 Checkpoint Pathway

edited by

Simona Serratì

and

Francesca Margheri

submission deadline 31 May 2025 | 9 articles | Viewed by 15347 | Submission Open

Keywords: immunotherapy; biomarkers; PD-1/PD-L1

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Mechanism and Regulation of Lifespan and Aging

edited by Mark McCormick

submission deadline 31 May 2025 | 5 articles | Viewed by 13699 | Submission Open

Keywords: aging; lifespan; healthspan

(This special issue belongs to the Section Molecular Biology)

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 May 2025 | 5 articles | Viewed by 11982 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products

edited by

Juei-Tang Cheng

submission deadline 31 May 2025 | 6 articles | Viewed by 9560 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 May 2025 | 6 articles | Viewed by 8895 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

State of the Art and Perspectives in Antimicrobial Peptides

edited by

Annarita Falanga

submission deadline 31 May 2025 | 6 articles | Viewed by 8753 | Submission Open

Keywords: antimicrobial peptides; AMPs; chemical modification of AMPs; function; structure; synthesis

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Sex and Evolution

edited by

Ikuo Miura

and

Michihiko Ito

submission deadline 31 May 2025 | 2 articles | Viewed by 8333 | Submission Open

Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates

(This special issue belongs to the Section Molecular Genetics)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 May 2025 | 4 articles | Viewed by 7195 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Infectious Pathogen Adaptation, Emergence, and Re-emergence

edited by

Rita Berisio

and

Alessia Ruggiero

submission deadline 31 May 2025 | 3 articles | Viewed by 7113 | Submission Open

Keywords: pathogen; structural biology; tuberculosis; function; molecular mechanism

(This special issue belongs to the Section Molecular Medicine)

Colorectal and Gastric Cancers: Molecular Mechanisms and Potential Biomarkers

edited by

Jan Bures

and

Nicholas J. W. Rattray

submission deadline 31 May 2025 | 3 articles | Viewed by 5869 | Submission Open

Keywords: colorectal cancer; gastric cancer; molecular mechanism; biomarkers signalling; molecules gastrointestinal; microbiome; artificial intelligence

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Mechanisms of Viral Infections

edited by

Ioannis Karakasiliotis

and

Christine Kottaridi

submission deadline 31 May 2025 | 5 articles | Viewed by 5484 | Submission Open

Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence

(This special issue belongs to the Section Molecular Biology)

Drosophila as a Model System to Study Metabolism

edited by

Justin R. DiAngelo

submission deadline 31 May 2025 | 5 articles | Viewed by 5356 | Submission Open

Keywords: carbohydrate; lipid; amino acid; Drosophila; metabolism; insulin; TOR; autophagy; fasting

(This special issue belongs to the Section Molecular Biology)

The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-Adipose Tissues

edited by

Gloria Lena Vega

and

Amalia Gastaldelli

submission deadline 31 May 2025 | 2 articles | Viewed by 4126 | Submission Open

Keywords: metabolic dysfunction-associated hepatosteatosis; myosteatosis; pancreatic steatosis; pancreatic adipocytes; visceral adipose tissue; cardiac steatosis; cardiac adipose tissue; kidney steatosis; macrophage steatosis; perirenal adipose tissue; lipophagy

(This special issue belongs to the Section Molecular Medicine)

Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights

edited by Fabián Flores-Borja,

Shunbin Ning

and

Michael Torzewski

submission deadline 31 May 2025 | 2 articles | Viewed by 3867 | Submission Open

Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors

(This special issue belongs to the Section Molecular Medicine)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 May 2025 | 2 articles | Viewed by 3702 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

New Insights into Neuroimmunology

edited by

Marc André Lécuyer

submission deadline 31 May 2025 | 1 articles | Viewed by 2916 | Submission Open

Keywords: neuroimmunology (in health and disease); multiple sclerosis (MS); experimental autoimmune encephalomyelitis (EAE); acute disseminated encephalomyelitis (ADEM); neuromyelitis optica spectrum disorders (NMOSD); transverse myelitis; anti-NMDA receptor encephalitis (NMDAR encephalitis); paraneoplastic autoimmune diseases; neurodegenerative diseases with immunological components; Parkinson’ s disease; Alzheimer’ s disease; neuroinfections

(This special issue belongs to the Section Cellular Biochemistry)

Aptamer Therapeutics in Cancers: New Advances and Future Trends

edited by

Silvia Catuogno

and

Silvia Nuzzo

submission deadline 31 May 2025 | 1 articles | Viewed by 2823 | Submission Open

Keywords: aptamers; cancer; targeted therapy; aptamer-based conjugates; aptamer-conjugated nanoparticles

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 31 May 2025 | 2 articles | Viewed by 2761 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Novel Antimicrobial Strategies for Animal Health

edited by

Anna Aris

and

Elena Garcia-Fruitos

submission deadline 31 May 2025 | 1 articles | Viewed by 2749 | Submission Open

Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease

(This special issue belongs to the Section Molecular Medicine)

Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

edited by

Alireza Shoari

, Joshua W. Ogony and

Gokara Mahesh

submission deadline 31 May 2025 | 1 articles | Viewed by 2392 | Submission Open

Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression

Mass Spectrometry Imaging in Neuroscience

edited by Nhu Thi Ngoc Phan

submission deadline 31 May 2025 | 1 articles | Viewed by 2336 | Submission Open

Keywords: mass spectrometry imaging; secondary ion mass spectrometry (SIMS); matrix-assisted laser desorption/ionization (MALDI); desorption electrospray ionization (DESI); laser ablation– inductively coupled plasma– mass spectrometry imaging (LA-ICP-MSI); multi-isotope imaging mass spectrometry (MIMS); molecular and organelle turnover; brain; neurons; synapses; neuronal stem cells; membrane lipids; synaptic proteins; neural peptides; metabolites; diseases; disorders

(This special issue belongs to the Section Molecular Medicine)

Role of Iron Dysregulation in Chronic Inflammatory Diseases and Their Complications

edited by

Asha R. Kallianpur

submission deadline 31 May 2025 | 1 articles | Viewed by 2034 | Submission Open

Keywords: iron; oxidative stress; ferroptosis; inflammation; chronic disease; metabolism; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Medicine)

Pharmacology of Cardiovascular Diseases

edited by

Istvan Lekli

, Alexandra Gyongyosi and

Istvan Bak

submission deadline 31 May 2025 | 2 articles | Viewed by 1854 | Submission Open

Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy

(This special issue belongs to the Section Molecular Medicine)

Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

edited by

Mykola Mamenko

and Brandi M. Wynne

submission deadline 31 May 2025 | 1 articles | Viewed by 1666 | Submission Open

Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release

(This special issue belongs to the Section Cellular Biochemistry)

Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets

edited by

S. Priya Narayanan

submission deadline 31 May 2025 | 1 articles | Viewed by 1549 | Submission Open

Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Biomarkers)

New Insights into Molecular Mechanisms and Therapeutics for Malaria

edited by

Maria Isabel Veiga

submission deadline 31 May 2025 | 1 articles | Viewed by 1514 | Submission Open

Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology

(This special issue belongs to the Section Molecular Medicine)

Vitamin D in Health and Disease—Honorary Special Issue Commemorating the Work of Dr. Luminita A. Stanciu

edited by

Corina I. Bocsan

and

Gavriela Maria Feketea

submission deadline 31 May 2025 | 1 articles | Viewed by 1445 | Submission Open

Keywords: vitamin D; immune cells; innate immunity; respiratory diseases; allergy; infections; metabolic disorders; cellular metabolism

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Adduct Science

edited by Yukari Totsuka and Haruhiko Sugimura

submission deadline 31 May 2025 | 1 articles | Viewed by 806 | Submission Open

Keywords: adductomics; protein- or nucleic acid-adducts; biomarkers; exposome; genomic mutations; disease etiology; preventive strategies; drug discovery; risk assessment

(This special issue belongs to the Section Biological Factors)

Recent Advances in Cellular and Non-Cellular Treatment of Stroke

edited by

David T. Harris

submission deadline 31 May 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: stroke; treatment; therapy; biomolecules; stem cells

(This special issue belongs to the Section Molecular Medicine)

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 May 2025 | 1 articles | Viewed by 606 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

Colorectal Cancer: Molecular Mechanism and Potential Biomarkers

edited by

Nicholas J. W. Rattray

and

Jan Bures

submission deadline 31 May 2025 | Viewed by 426 | Submission Open

Keywords: colorectal cancer; molecular mechanism; biomarkers; signalling molecules; gastrointestinal microbiome; artificial intelligence

(This special issue belongs to the Section Molecular Medicine)

Calcium Signaling in Cell Function and Dysfunction

edited by

Giorgia Pallafacchina

and Sofia Zanin

submission deadline 31 May 2025 | Viewed by 394 | Submission Open

Keywords: calcium signaling; calcium regulation; cell function; human pathology

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Therapies of SARS-CoV-2

edited by

Grzegorz Przybylski

and Piotr Kopiński

submission deadline 31 May 2025 | Viewed by 390 | Submission Open

Keywords: ARDS in COVID-19; COVID-19 therapies; COVID-19 vaccines; immune systems in COVID-19; long-COVID pathogenesis; SARS-Cov-2 genomics; SARS-Cov-2 variants; T-cells in COVID-19

Genetics and Epigenetics of Breast Cancer

edited by