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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology

edited by

Paolo Fagone

submission deadline 31 Oct 2025 | 8 articles | Viewed by 20538

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition

edited by

Carmen Cerchia

and

Antonio Lavecchia

submission deadline 31 Oct 2025 | 7 articles | Viewed by 17229

Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition

edited by

and

submission deadline 31 Oct 2025 | 7 articles | Viewed by 14993

Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems

(This special issue belongs to the Section Molecular Medicine)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 Oct 2025 | 4 articles | Viewed by 13876

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

Advances in Cellular Biophysics: Transport and Mechanics

edited by Boris Musset and

Peter Pohl

submission deadline 31 Oct 2025 | 7 articles | Viewed by 11915

Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Drosophila as a Model System to Study Metabolism

edited by

Justin R. DiAngelo

submission deadline 31 Oct 2025 | 7 articles | Viewed by 10849

Keywords: carbohydrate; lipid; amino acid; Drosophila; metabolism; insulin; TOR; autophagy; fasting

(This special issue belongs to the Section Molecular Biology)

Molecular and Genetic Basis of Neurodegenerative Diseases

edited by Teresa M. Gunn and Andrea Grindeland

submission deadline 31 Oct 2025 | 6 articles | Viewed by 9046

Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation

(This special issue belongs to the Section Molecular Genetics)

Application of Bioinformatics in Medicine

edited by

Le Zhang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 7246

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

New Insights into the Membranes of Anoxygenic Phototrophic Bacteria

edited by

Robert A. Niederman

submission deadline 31 Oct 2025 | 4 articles | Viewed by 6010

Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5465

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

Crosstalk Between the Immune and Nervous Systems

edited by

Fuminori Tsuruta

submission deadline 31 Oct 2025 | 1 articles | Viewed by 3321

Keywords: microglia; astrocytes; macrophages; cerebral blood vessels; cerebrospinal fluid (CSF); meninges; immune cells; neuroinflammation; neurodegenerative disorders; psychiatric disorders

(This special issue belongs to the Section Molecular Biology)

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2596

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

Molecular and Cellular Mechanisms of Kidney Diseases

edited by

Theodoros Eleftheriadis

and Maria Divani

submission deadline 31 Oct 2025 | 1 articles | Viewed by 2272

Keywords: chronic kidney disease; acute kidney injury; kidney transplantation; glomerular diseases; ischemia– reperfusion injury; diabetic nephropathy

(This special issue belongs to the Section Molecular Biology)

Molecular Basis and Novel Treatment of Epilepsy

edited by

Fang Zheng

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1849

Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research

(This special issue belongs to the Section Molecular Biology)

Involved Biomolecules Within Lysosomal Energy Sensing in Health and Disease

edited by Xianrui Yang and

L. Shannon Holliday

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1840

Keywords: lysosomal energy sensing; vacuolar H+-ATPase (V-ATPase); 5’ -AMP-activated kinase (AMPK); mammalian target of rapamycin (mTor); sirtuin; aldolase; TRPV1; metformin; rapamycin

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Molecular Genetics of Bacteria

edited by Bin Jia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1697

Keywords: bacterial gene regulation; CRISPR-Cas systems; bacterial resistance; microbial genomics; genome-wide association studies; bacterial pathogenesis; genetic diversity

(This special issue belongs to the Section Molecular Genetics)

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1691

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Inflammation and Hemostasis: 2nd Edition

edited by

Zsuzsa Bagoly

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1492

(This special issue belongs to the Section Molecular Medicine)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1319

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1295

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition

edited by

Toshiyuki Sakaki

and Naoko Tsugawa

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1075

Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450

(This special issue belongs to the Section Chemical Biology)

Studies of Protein Dynamics Using Fluorescence Correlation Spectroscopy (FCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 31 Oct 2025 | Viewed by 409

Keywords: protein dynamics; Fluorescence Correlation Spectroscopy (FCS); protein interactions; subcellular environments; Image Correlation Spectroscopy(ICS) and extensions

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism

edited by Udai P. Singh

submission deadline 31 Oct 2025 | Viewed by 277

Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease

(This special issue belongs to the Section Biological Factors)

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 Oct 2025 | Viewed by 230

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 31 Oct 2025 | Viewed by 175

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Medicine)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 Oct 2025 | Viewed by 159

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Genetics and Cell Biology in Neuroblastoma

edited by

Dirk Geerts

submission deadline 31 Oct 2025 | Viewed by 112

Keywords: genetics; genomics; neuroblastoma; precision medicine; transcriptomics

(This special issue belongs to the Section Cellular Biochemistry)

Zebrafish Models in Cardiovascular and Metabolic Precision Medicine

edited by

Angom Ramcharan Singh

submission deadline 7 Nov 2025 | Viewed by 192 | Submission Open

Keywords: zebrafish models; cardiovascular disease; metabolic disorders; precision medicine; genetic screening; drug discovery; disease modeling; translational research; personalized therapy; high-throughput screening

Protein Structure Prediction in Drug Discovery: 2nd Edition

edited by

Alessandro Paiardini

submission deadline 15 Nov 2025 | 6 articles | Viewed by 31413 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Neuroproteomics

edited by

Kenneth R. Williams

and

Angus C. Nairn

submission deadline 15 Nov 2025 | 10 articles | Viewed by 29393 | Submission Open

Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Interface of Aging and Biomaterials: 2nd Edition

edited by

Joshua T. Morgan

submission deadline 15 Nov 2025 | 3 articles | Viewed by 13506 | Submission Open

Keywords: aging; senescence; geroscience; biomolecules; biomaterials; biocompatibility; nanoparticles; hydrogels

(This special issue belongs to the Section Bio-Engineered Materials)

Recent Advances in Mass Spectrometry-Based Proteomics

edited by

An Staes

and Simon Devos

submission deadline 15 Nov 2025 | Viewed by 170 | Submission Open

Keywords: LC-MS/MS proteomics; high-throughput; low input proteomics; clinical proteomics; spatial proteomics; immunopeptidomics; post-translational protein modifications; biomarker discovery; drug targets

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques

edited by

Rohit Jain

, Corie Ralston and

Gang (Gary) Ren

submission deadline 20 Nov 2025 | 2 articles | Viewed by 7610 | Submission Open

Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in the Structure and Function of Microtubule-Associated Motor Proteins

edited by Arne Gennerich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1536 | Submission Open

Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Notch and Its Regulation in Health and Disease

edited by

Martin Baron

submission deadline 20 Nov 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: Notch; signalling; development; diseases

(This special issue belongs to the Section Molecular Medicine)

Design and Synthesis of Bioactive Compounds for Therapeutic Applications

edited by

Gerald Guillaumet

and

Saïd El Kazzouli

submission deadline 30 Nov 2025 | 11 articles | Viewed by 20661 | Submission Open

Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Integrins

edited by

Yoshikazu Takada

submission deadline 30 Nov 2025 | 6 articles | Viewed by 17557 | Submission Open

Keywords: integrins; growth factors; ligands

(This special issue belongs to the Section Biological Factors)

Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 30 Nov 2025 | 6 articles | Viewed by 15322 | Submission Open

Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’ s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; SARS-CoV-2; spike protein; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics

(This special issue belongs to the Section Chemical Biology)

Molecular Aspects of Female Infertility

edited by

Mara Marongiu

submission deadline 30 Nov 2025 | 6 articles | Viewed by 13072 | Submission Open

Keywords: female infertility; reproduction; ovary; reproductive aging; genetic disorders

(This special issue belongs to the Section Molecular Biology)

Advances in p53 Research

edited by

Gabriella D’Orazi

submission deadline 30 Nov 2025 | 3 articles | Viewed by 12375 | Submission Open

Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)

(This special issue belongs to the Section Molecular Biology)

Colorectal and Gastric Cancers: Molecular Mechanisms and Potential Biomarkers

edited by

Jan Bures

and

Nicholas J. W. Rattray

submission deadline 30 Nov 2025 | 5 articles | Viewed by 10888 | Submission Open

Keywords: colorectal cancer; gastric cancer; molecular mechanism; biomarkers signalling; molecules gastrointestinal; microbiome; artificial intelligence

(This special issue belongs to the Section Molecular Biomarkers)

The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8732 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Skeletal Muscle in Health, Exercise and Aging

edited by Barbara Munz

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8559 | Submission Open

Keywords: skeletal muscle; molecular mechanisms of exercise adaptation; aging; cachexia; sarcopenia

(This special issue belongs to the Section Molecular Biology)

Microbial Biocontrol and Plant-Microbe Interactions

edited by

Shahzad Munir

submission deadline 30 Nov 2025 | 6 articles | Viewed by 7887 | Submission Open

Keywords: endophytic microbiome for disease management; plant– microbe interactions; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response

(This special issue belongs to the Section Cellular Biochemistry)

Mechanisms of Kidney Injury and Treatment Modalities

edited by Utpal Sen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5024 | Submission Open

Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration

(This special issue belongs to the Section Molecular Biology)

Mass Spectrometry Imaging in Neuroscience

edited by Nhu Thi Ngoc Phan

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5003 | Submission Open

Keywords: mass spectrometry imaging; secondary ion mass spectrometry (SIMS); matrix-assisted laser desorption/ionization (MALDI); desorption electrospray ionization (DESI); laser ablation– inductively coupled plasma– mass spectrometry imaging (LA-ICP-MSI); multi-isotope imaging mass spectrometry (MIMS); molecular and organelle turnover; brain; neurons; synapses; neuronal stem cells; membrane lipids; synaptic proteins; neural peptides; metabolites; diseases; disorders

(This special issue belongs to the Section Molecular Medicine)

Metabolic Inflammation and Insulin Resistance in Obesity

edited by Bingxian Xie

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4514 | Submission Open

Keywords: obesity-linked inflammation; insulin resistance; adipose tissue

(This special issue belongs to the Section Lipids)

Properties and Functions of Endometrial Stromal Cells

edited by

Toshihiro Sakurai

and

Mikihiro Yoshie

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4270 | Submission Open

Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology

(This special issue belongs to the Section Molecular Reproduction)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4090 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Advances in Cancer and Glycosylation

edited by

Myron R. Szewczuk

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3672 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

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