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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jan 2026 | 8 articles | Viewed by 29534 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Updates on Mitochondria and Cancer

edited by

Antonella Cormio

and

Clara Musicco

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2713 | Submission Open

Keywords: mitochondrial dysfunction in cancer; mitochondrial metabolomics; mitochondria and cancer therapy; mitochondria and cancer drug resistance; prognostic/predictive mitochondrial markers in cancer tissues and body fluids

(This special issue belongs to the Section Biological Factors)

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jan 2026 | Viewed by 422 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jan 2026 | Viewed by 378 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Skeletal Muscle Homeostasis and Regeneration: 2nd Edition

edited by

Ernő Zádor

submission deadline 15 Jan 2026 | Viewed by 129 | Submission Open

Keywords: skeletal muscle; homeostasis; regeneration; satellite cells; fiber type

(This special issue belongs to the Section Molecular Medicine)

Lipid Signaling in Neuroinflammation and Neurodegeneration

edited by

Jason R. Gerstner

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2456 | Submission Open

Keywords: lipid signaling; neuroinflammation; neurodegeneration; sphingolipids; eicosanoids; phospholipids; endocannabinoids; lipid mediators; molecular mechanisms; brain health

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jan 2026 | 9 articles | Viewed by 34601 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Feature Papers in Cellular Biochemistry

edited by

Anna Rita Franco Migliaccio

submission deadline 31 Jan 2026 | 9 articles | Viewed by 31232 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 31 Jan 2026 | 8 articles | Viewed by 27397 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Medicine: A Themed Issue in Honor of Prof. Dr. Carl A. Pinkert

edited by

Matthew McKenzie

submission deadline 31 Jan 2026 | 5 articles | Viewed by 26788 | Submission Open

Keywords: mitochondrial biology; mitochondrial disease; mitochondrial DNA; mitochondrial medicine; metabolism; therapeutics; oxidative phosphorylation; reactive oxygen species

(This special issue belongs to the Section Molecular Medicine)

Harnessing Protein Design and Engineering for Therapeutic Applications

edited by Julia Shifman and Norman Metanis

submission deadline 31 Jan 2026 | 6 articles | Viewed by 21144 | Submission Open

Keywords: therapeutic peptides and proteins; protein design and engineering; chemical protein synthesis; chemoselective protein modification; posttranslational protein modification

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Jan 2026 | 8 articles | Viewed by 20995 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 31 Jan 2026 | 4 articles | Viewed by 15205 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

Cellular and Molecular Mechanisms in Cardiopathy and Therapeutic Strategies

edited by Ying-Hsi Lin and Shengjie Lu

submission deadline 31 Jan 2026 | 8 articles | Viewed by 14650 | Submission Open

Keywords: heart failure; cardiac remodelling; contractile dysfunction; bioenergetics; gene replacement or editing

(This special issue belongs to the Section Molecular Medicine)

Digestive Enzymes in Health and Disease

edited by Stefan G. Pierzynowski, Kateryna Pierzynowska,

Piotr Wychowański

and

Janine Donaldson

submission deadline 31 Jan 2026 | 6 articles | Viewed by 13303 | Submission Open

Keywords: digestive enzymes; gastrointestinal health; enzyme replacement therapy; gut microbiome; metabolic disorders; enzyme regulation; disease biomarkers; inflammatory diseases; nutrient absorption; therapeutic enzymes

(This special issue belongs to the Section Enzymology)

Advances in Metabolites Produced by Microbiota

edited by

Arancha Llama-Palacios

submission deadline 31 Jan 2026 | 3 articles | Viewed by 11609 | Submission Open

Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins

(This special issue belongs to the Section Cellular Biochemistry)

Advanced Biomaterials for Healing Oral Tissues

edited by Miki Taketomi Saito and

Rafael R. Lima

submission deadline 31 Jan 2026 | 1 articles | Viewed by 9803 | Submission Open

Keywords: biocompatible materials; biopolymers; dental implants; materials testing; pharmaceutical preparations; regeneration; regenerative medicine; tissue scaffolds; wound healing

(This special issue belongs to the Section Bio-Engineered Materials)

Retinal Diseases: Molecular Mechanisms and Therapies

edited by

Ana Raquel Santiago

and Raquel Boia

submission deadline 31 Jan 2026 | 3 articles | Viewed by 9064 | Submission Open

Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments

(This special issue belongs to the Section Cellular Biochemistry)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 31 Jan 2026 | 4 articles | Viewed by 9063 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

(This special issue belongs to the Section Molecular Biology)

Pharmacology of Cardiovascular Diseases

edited by

Istvan Lekli

, Alexandra Gyongyosi and

Istvan Bak

submission deadline 31 Jan 2026 | 3 articles | Viewed by 8682 | Submission Open

Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Rett Syndrome and Other Chromatin Related Disorders

edited by

Floriana Della Ragione

and Salvatore Fioriniello

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5733 | Submission Open

Keywords: Rett syndrome and other chromatin disorders; epigenetic diseases; molecular alterations in Rett syndrome and other chromatin diseases; novel genes associated with chromatin disorders; MeCP2-mediated molecular mechanisms; roles of epigenetic modulators in chromatin-related diseases; preclinical studies for chromatin diseases; novel diagnostic; prognostic and therapeutic approaches for chromatin disorders

(This special issue belongs to the Section Molecular Medicine)

Advances and Novel Strategies for Studying Underexplored Post-Translational Modifications (PTMs)

edited by

Yue Chen

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5657 | Submission Open

Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging

(This special issue belongs to the Section Molecular Biology)

Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies

edited by

Susanna Pietropaolo

and Bruno Bontempi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5207 | Submission Open

Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Novel Treatments of Stroke

edited by

Saif Ahmad

and Naseem Akhter

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4750 | Submission Open

Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches

(This special issue belongs to the Section Molecular Biology)

Pluripotent Stem Cells: From Basic Research to Therapeutic Applications

edited by

Claudia Spits

and

Diana Al Delbany

submission deadline 31 Jan 2026 | 1 articles | Viewed by 4039 | Submission Open

Keywords: pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells; organoids; differentiation; regenerative medicine; disease modeling; cell therapy; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Natural Products and Their Derivatives with Antiviral Activity

edited by

Zhijun Zhang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3894 | Submission Open

Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Key Molecules Regulating Plant Response to Abiotic Stress: Transcription Factors and Stress-Induced Proteins

edited by

Fei Gao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2764 | Submission Open

Keywords: abiotic stress response; transcription factors; stress-induced proteins; molecular mechanisms; transcriptomics; omics; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2569 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Current Advances of Metal Complexes for Biomedical Applications

edited by

Marcelino Maneiro

and

Sandra Fernández-Fariña

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2479 | Submission Open

Keywords: metal complexes; metals in medicine; bioinorganic; anti-cancer; antiviral; anti-inflammatory; antioxidant; imaging applications

(This special issue belongs to the Section Chemical Biology)

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants: 2nd Edition

edited by

Daniela Grimm

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2203 | Submission Open

Keywords: cells; humans; animals; plants; microorganisms; microgravity; weightlessness; cancer research; tissue engineering; space-related health problems

(This special issue belongs to the Section Cellular Biochemistry)

State-of-the-Art Protein X-Ray Crystallography

edited by Wu-Pei Su and

Hongxing He

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1731 | Submission Open

Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Developmental Biology of the Kidney: From Molecular Mechanisms to Congenital Disorders

edited by

Katarina Vukojević

and Anita Racetin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1664 | Submission Open

Keywords: kidney development; renal physiology; kidney disease; molecular mechanisms; cellular signaling; gene expression; biomarkers; renal pathophysiology; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Lung Disease: From Molecular Mechanism to Therapeutic Opportunities

edited by

Patrick G. Arndt

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1529 | Submission Open

Keywords: biomarkers; pharmacotherapeutics; cell signaling; innate immunity; inflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1183 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

(This special issue belongs to the Section Molecular Medicine)

Synthesis, Characterization and Validation of Small Molecule Compounds

edited by Mohamed Fares Metwaly

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1115 | Submission Open

Keywords: medicinal chemistry; structure-based drug design; enzyme inhibitors; multi-target therapeutics

(This special issue belongs to the Section Molecular Biology)

Alcohol Consumption as a Cardiovascular Risk Factor: Focusing on Molecular Mechanisms

edited by

Ichiro Wakabayashi

and

Klaus Groschner

submission deadline 31 Jan 2026 | 1 articles | Viewed by 941 | Submission Open

Keywords: alcohol; ethanol metabolism; ethanol– protein interactions; ethanol– membrane interactions; cardiovascular health and disease

(This special issue belongs to the Section Molecular Medicine)

New Insights into Mesothelial Cells

edited by Francesca Bodega and Cristina Porta

submission deadline 31 Jan 2026 | 2 articles | Viewed by 938 | Submission Open

Keywords: mesothelial cells; serous cavities; lubricating fluids; epithelial– mesenchymal transition; fibrosis; tissue repair; mesothelioma; tumor microenvironment; immune response

(This special issue belongs to the Section Molecular Biology)

Inflammation Biology in Orthodontic Tooth Movement

edited by

Masaru Yamaguchi

submission deadline 31 Jan 2026 | Viewed by 434 | Submission Open

Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse

(This special issue belongs to the Section Biological Factors)

Mechanisms of Gene Regulation in Embryos

edited by

Jo Qian

and Adam Davis

submission deadline 31 Jan 2026 | Viewed by 383 | Submission Open

Keywords: embryonic development; gene regulation; epigenetics; transcriptional control; post-transcriptional control; translational control; post-translational modification; signaling pathways; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Therapy Targeting DNA Damage and Repair Systems

edited by

Joy Mitra

Anirban Chakraborty

and Anahita Mojiri

submission deadline 31 Jan 2026 | Viewed by 362 | Submission Open

Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis

(This special issue belongs to the Section Biological Factors)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Davide Brocco

submission deadline 31 Jan 2026 | Viewed by 346 | Submission Open

Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy

(This special issue belongs to the Section Molecular Biology)

Genomics and Molecular Biology of Solid Tumors

edited by Dragoş Creţoiu and Silviu Cristian Voinea

submission deadline 31 Jan 2026 | Viewed by 332 | Submission Open

Keywords: solid tumors; tumor microenvironment; genomic instability; cancer stem cells; liquid biopsy

(This special issue belongs to the Section Molecular Biology)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 31 Jan 2026 | Viewed by 331 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

Metabolic Diseases: From Molecular Mechanisms to Therapy Strategies

edited by

Livia Lenzini

and

Nicola Vitturi

submission deadline 31 Jan 2026 | Viewed by 296 | Submission Open

Keywords: inborn errors of metabolism; molecular mechanisms; gene identification; therapeutic; approaches; translation

Molecular Biology and Therapy of Breast Cancer

edited by

Norbert Nass

submission deadline 31 Jan 2026 | Viewed by 241 | Submission Open

Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA

Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 31 Jan 2026 | Viewed by 237 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

Nucleic Acid-Lipid Interactions: Bridging Molecular Insights with Therapeutic Applications

edited by Weiwei He and Serdal Kirmizialtin

submission deadline 31 Jan 2026 | Viewed by 236 | Submission Open

Keywords: nucleic acids; lipid membranes; interactions; structural transitions; physical mechanism

Endometriosis: Molecular Pathogenesis and Translational Implications

edited by

Ie-Ming Shih

submission deadline 31 Jan 2026 | Viewed by 187 | Submission Open

Keywords: endometriosis; pathogenesis; adenomyosis; diagnosis; detection

(This special issue belongs to the Section Molecular Medicine)

Genetic and Epigenetic Mechanisms Underlying Neurodevelopmental Disorders

edited by

Andrea L. Gropman

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: neurodevelopmental disorders; epigenetics; gene– environment interaction; chromatin remodeling; neurogenomics

(This special issue belongs to the Section Molecular Genetics)

Mechanisms in Stress-Related Disorders, Anxiety and Fear

edited by Veronica Begni

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

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