Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Sep 2025 | Viewed by 404 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies
edited by and
submission deadline 30 Sep 2025 | 8 articles | Viewed by 30743 | Submission Open
Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy
(This special issue belongs to the Section Molecular Medicine)
Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience
edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim
submission deadline 30 Sep 2025 | 10 articles | Viewed by 25755 | Submission Open
Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology
(This special issue belongs to the Section Molecular Biology)
Prebiotics and Probiotics in Health and Disease: Looking at the Future submission deadline 30 Sep 2025 | 8 articles | Viewed by 23834 | Submission Open
Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics
(This special issue belongs to the Section Molecular Medicine)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 18783 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Pathogenesis and Neuropathology of Alzheimer's Disease submission deadline 30 Sep 2025 | 7 articles | Viewed by 15296 | Submission Open
Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
(This special issue belongs to the Section Molecular Medicine)
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 7 articles | Viewed by 13515 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Amyloid-Beta and Alzheimer’s Disease submission deadline 30 Sep 2025 | 6 articles | Viewed by 11645 | Submission Open
Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD
(This special issue belongs to the Section Cellular Biochemistry)
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System
edited by Peng Yao and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 8702 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 7953 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 6490 | Submission Open
Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Cellular Quiescence and Dormancy
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 6440 | Submission Open
Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva
(This special issue belongs to the Section Molecular Genetics)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 5018 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 30 Sep 2025 | 1 articles | Viewed by 4499 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition submission deadline 30 Sep 2025 | 4 articles | Viewed by 4047 | Submission Open
Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis
(This special issue belongs to the Section Molecular Biomarkers)
Lipids Metabolism in Cardiovascular Disease
edited by Anand K. Rohatgi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3505 | Submission Open
Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Therapeutic Targets in Leukaemia
edited by and
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3080 | Submission Open
Keywords: leukaemia; blood; genetics; genomics; chromosome
(This special issue belongs to the Section Molecular Medicine)
Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges submission deadline 30 Sep 2025 | 2 articles | Viewed by 2910 | Submission Open
Keywords: biomarker; molecular biology; bioinformatics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Cancer Epigenetics, Post-Translational Modification, and Drug Discovery
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2756 | Submission Open
Keywords: cancer; drug Discovery; epigenetics; inflammation; NF– κ B
(This special issue belongs to the Section Cellular Biochemistry)
DNA Damage and Repair in Cancer Treatment submission deadline 30 Sep 2025 | 1 articles | Viewed by 2020 | Submission Open
Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis
(This special issue belongs to the Section Molecular Biology)
Role of Postbiotics on Health Maintenance and Recovery
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1997 | Submission Open
Keywords: human microbiota; postbiotics; lantibiotics; SCFAs; SCFAs receptors; immune regulation; synbiotics; psychobiotics; dysbiosis; TMAO
(This special issue belongs to the Section Molecular Biology)
Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)
edited by and Alexander John Dear
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1720 | Submission Open
Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition
edited by Jasmina Dimitrić Marković, and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1512 | Submission Open
Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery
Molecular Mechanisms and Genetics of Human Disease
edited by and Ata Abbas
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1399 | Submission Open
Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication
(This special issue belongs to the Section Molecular Genetics)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2025 | 1 articles | Viewed by 1152 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 924 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
New Insights into Hormonal Control of Plant Growth and Development
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 771 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Molecular Biology)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Sep 2025 | 1 articles | Viewed by 649 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies
edited by
submission deadline 30 Sep 2025 | Viewed by 232 | Submission Open
Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies
(This special issue belongs to the Section Molecular Medicine)
Advances in Microbial CRISPR Editing
edited by and Rongming Liu
submission deadline 30 Sep 2025 | Viewed by 165 | Submission Open
Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems
(This special issue belongs to the Section Molecular Biology)
Cell Death and Clearance
edited by and Jascinta Santavanond
submission deadline 30 Sep 2025 | Viewed by 153 | Submission Open
Keywords: cell death; apoptosis; efferocytosis; cell clearance
(This special issue belongs to the Section Molecular Medicine)
The Role and Metabolism of Metals in Cancer submission deadline 30 Sep 2025 | Viewed by 151 | Submission Open
Keywords: metals; cancer; cancer metabolism
(This special issue belongs to the Section Chemical Biology)
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Sep 2025 | Viewed by 140 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Sep 2025 | Viewed by 114 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Molecular Mechanisms of Human Skin Aging
edited by
submission deadline 15 Oct 2025 | 4 articles | Viewed by 15630 | Submission Open
Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention
(This special issue belongs to the Section Molecular Medicine)
Regulation of Synapses in the Brain
edited by and Guohao Wang
submission deadline 15 Oct 2025 | 1 articles | Viewed by 650 | Submission Open
Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Mechanisms of RNA Regulation in Inflammation
edited by
submission deadline 15 Oct 2025 | Viewed by 99 | Submission Open
Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Genetics)
Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications submission deadline 16 Oct 2025 | 1 articles | Viewed by 556 | Submission Open
Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation
(This special issue belongs to the Section Chemical Biology)
Molecular Biomarkers of Epileptogenesis
edited by Pedro J. Serrano-Castro
submission deadline 20 Oct 2025 | 3 articles | Viewed by 8280 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications
edited by George Kokotos and
submission deadline 25 Oct 2025 | Viewed by 102 | Submission Open
Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes
(This special issue belongs to the Section Molecular Medicine)
Molecular and Cellular Mechanisms in Skin Disorders
edited by
submission deadline 30 Oct 2025 | 2 articles | Viewed by 2329 | Submission Open
Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ
(This special issue belongs to the Section Molecular Biology)
Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology
edited by
submission deadline 31 Oct 2025 | 8 articles | Viewed by 16172 | Submission Open
Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy
(This special issue belongs to the Section Cellular Biochemistry)
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition submission deadline 31 Oct 2025 | 7 articles | Viewed by 15346 | Submission Open
Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning
(This special issue belongs to the Section Bioinformatics and Systems Biology)
New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 Oct 2025 | 7 articles | Viewed by 12876 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Liver Damage and Associated Metabolic Disorders
edited by
submission deadline 31 Oct 2025 | 4 articles | Viewed by 11087 | Submission Open
Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses
(This special issue belongs to the Section Molecular Medicine)
Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition submission deadline 31 Oct 2025 | 7 articles | Viewed by 11085 | Submission Open
Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems
(This special issue belongs to the Section Molecular Medicine)
Drosophila as a Model System to Study Metabolism
edited by
submission deadline 31 Oct 2025 | 6 articles | Viewed by 8881 | Submission Open
Keywords: carbohydrate; lipid; amino acid; Drosophila; metabolism; insulin; TOR; autophagy; fasting
(This special issue belongs to the Section Molecular Biology)
Advances in Cellular Biophysics: Transport and Mechanics
edited by Boris Musset and
submission deadline 31 Oct 2025 | 5 articles | Viewed by 8499 | Submission Open
Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Molecular and Genetic Basis of Neurodegenerative Diseases
edited by Teresa M. Gunn and Andrea Grindeland
submission deadline 31 Oct 2025 | 6 articles | Viewed by 7952 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation
(This special issue belongs to the Section Molecular Genetics)
Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by and
submission deadline 31 Oct 2025 | 3 articles | Viewed by 7902 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity
(This special issue belongs to the Section Molecular Medicine)
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