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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience

edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim

submission deadline 30 Jun 2025 | 10 articles | Viewed by 22884 | Submission Open

Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology

(This special issue belongs to the Section Molecular Biology)

Advances in Protein-Ligand Interactions: From Structure, Function to Applications

edited by

Mateusz Banach

submission deadline 30 Jun 2025 | 7 articles | Viewed by 20497 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Inositol Phosphates in Health and Disease, 2nd Edition

edited by

Ivana Vucenik

and

Abulkalam M. Shamsuddin

submission deadline 30 Jun 2025 | 6 articles | Viewed by 14459 | Submission Open

Keywords: inositol polyphosphates (IPs); IP6; inositol pyrophosphate (PP-Ips); signal transduction; energy metabolism; anticancer activity; PCOS; metabolic diseases; pathological calcification; neuropsychiatric disease

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Medicine: A Themed Issue in Honor of Prof. Dr. Carl A. Pinkert

edited by

Matthew McKenzie

submission deadline 30 Jun 2025 | 5 articles | Viewed by 12624 | Submission Open

Keywords: mitochondrial biology; mitochondrial disease; mitochondrial DNA; mitochondrial medicine; metabolism; therapeutics; oxidative phosphorylation; reactive oxygen species

(This special issue belongs to the Section Molecular Medicine)

Harnessing Protein Design and Engineering for Therapeutic Applications

edited by Julia Shifman and Norman Metanis

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11644 | Submission Open

Keywords: therapeutic peptides and proteins; protein design and engineering; chemical protein synthesis; chemoselective protein modification; posttranslational protein modification

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 30 Jun 2025 | 2 articles | Viewed by 9211 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Cutting-Edge Research on the Analysis of Small Biomolecules in Foods, Plants, and Biological Samples, 2nd Edition

edited by

Maroula Kokotou

Petros Tarantilis

and

Christos Pappas

submission deadline 30 Jun 2025 | 5 articles | Viewed by 9125 | Submission Open

Keywords: bioactive food ingredients (primary and secondary metabolites); secondary metabolites— natural products liquid chromatography-mass spectrometry; Fourier transform infrared (FTIR) and Raman spectroscopic analysis; gas chromatography-mass spectrometry; high-resolution mass spectrometry; lipids— amino acids— carbohydrates; polyphenols– terpenes

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 30 Jun 2025 | 2 articles | Viewed by 7119 | Submission Open

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

The Immune System and Allergies

edited by

Marco Casciaro

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6896 | Submission Open

Keywords: immune system; allergy; inflammation; hypersensitivity; immunology

(This special issue belongs to the Section Cellular Biochemistry)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5932 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

(This special issue belongs to the Section Molecular Biology)

Feature Papers in Cellular Biochemistry

edited by

Anna Rita Franco Migliaccio

submission deadline 30 Jun 2025 | 5 articles | Viewed by 5897 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Liver X Receptors

edited by Kaori Endo-Umeda and

Makoto Makishima

submission deadline 30 Jun 2025 | 3 articles | Viewed by 5845 | Submission Open

Keywords: liver X receptor; lipid metabolism; cholesterol; oxysterol; atherosclerosis; non-alcoholic steatohepatitis; inflammation; tumor immunity

(This special issue belongs to the Section Molecular Biology)

Human Reproductive Biology: Uncertainties and Controversies

edited by

Giuseppe Benagiano

Marwan Habiba

and Paola Bianchi

submission deadline 30 Jun 2025 | 2 articles | Viewed by 5691 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Innovative Biomolecular Structure Analysis Techniques

edited by Tzanko I. Doukov

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4283 | Submission Open

Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

The Next Generation of Proteomics for Precision Medicine: Second Edition

edited by

Towia Libermann

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4115 | Submission Open

Keywords: proteomics; biomarkers; next-generation protein sequencing; diagnostics; protein quantitative trait locus; systems biology; precision medicine

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Neurodevelopmental Disorders: Genetic Studies and Therapeutic Strategies

edited by

Susanna Pietropaolo

and Bruno Bontempi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3686 | Submission Open

Keywords: mouse models; Autism Spectrum disorder; transgenic rodents; pharmacological treatments; gene-environment interactions; neurodevelopmental disorders; rare diseases

(This special issue belongs to the Section Molecular Genetics)

Molecular Basis of Stress- and Trauma-Related Disorders

edited by Vanessa Nieratschker

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3642 | Submission Open

Keywords: stress; trauma; epigenetics; genetics; molecular mechanisms; transgenerational transmission; neuronal adaptations; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Medicine)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3404 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

Retinal Diseases: Molecular Mechanisms and Therapies

edited by

Ana Raquel Santiago

and Raquel Boia

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3161 | Submission Open

Keywords: retinal diseases; molecular mechanisms; therapeutic strategies; vision impairment; gene therapy; retinal degeneration; neuroprotection; innovative treatments

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Modulating Intracellular Signaling in Immune System

edited by

Jian Song

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2971 | Submission Open

Keywords: signaling pathway; inflammation; autoimmune disease; treatment

(This special issue belongs to the Section Molecular Biology)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2756 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Ligamentum Flavum Fibrosis and Hypertrophy

edited by

Prashanta Silwal

and Peter G. Alexander

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2723 | Submission Open

Keywords: lumbar spinal stenosis; ligamentum flavum hypertophy; fibrosus; stem cells; cell signaling; immunoregulation; aging and senescence; magnetic resonance imaging

Immune Modulation and Atherosclerosis

edited by Xinjie Lu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2342 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; immune modulatory therapy; vaccinations

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2335 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

Biomarkers in Metabolic Diseases, 2nd Edition

edited by

Anna Tylki-Szymańska

and

Patryk Lipiński

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2137 | Submission Open

Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy

(This special issue belongs to the Section Molecular Biomarkers)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1917 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

New Insights into Protein Aggregation in Condensed and Amyloid States

edited by

Eva Žerovnik

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1879 | Submission Open

Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression

edited by

Kiyoshi Ohtani

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1787 | Submission Open

Keywords: E2F; RB; p53; cancer; tumor suppression

(This special issue belongs to the Section Biological Factors)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1471 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 30 Jun 2025 | Viewed by 511 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Regeneration of Annelids: From Reorganization of Lost Body Parts to Cellular and Molecular Biological Background

edited by

László Molnár

submission deadline 30 Jun 2025 | Viewed by 462 | Submission Open

Keywords: regeneration; body plan; dedifferentiation; stem cells; morphallaxis; epimorphosis; neuro-immune interactions

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Biomolecular Research: Selected Papers from the 2024 Biomedical Sciences Symposium

edited by Yuri Nesmelov and Jun-Tao Guo

submission deadline 30 Jun 2025 | Viewed by 377 | Submission Open

Keywords: cancer biology; regenerative medicine; infectious disease; artificial intelligence in health research; nanomaterials; drug design

Advances in Computational Approaches for the Discovery of Therapeutics and Personalized Medicine

edited by

Supriyo Bhattacharya

submission deadline 30 Jun 2025 | Viewed by 288 | Submission Open

Keywords: high-throughput virtual screening; CADD; machine learning; biologics design; off-target effect prediction

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Interactions between Obesity and Breast Cancer

edited by Fokhrul Hossain

submission deadline 30 Jun 2025 | Viewed by 240 | Submission Open

Keywords: breast cancer; breast cancer subtypes; triple-negative breast cancer; obesity; molecular mechanisms; molecular interactions

(This special issue belongs to the Section Molecular Medicine)

Regulation Mechanisms of Autophagy in Aging

edited by

Patricia Gomez-Suaga

submission deadline 30 Jun 2025 | Viewed by 209 | Submission Open

Keywords: autophagy; cellular senescence; protein aggregation; mitochondrial dysfunction; aging

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 30 Jun 2025 | Viewed by 191 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Jun 2025 | Viewed by 188 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 30 Jun 2025 | Viewed by 178 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 30 Jun 2025 | Viewed by 169 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 30 Jun 2025 | Viewed by 159 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

Nano-Based Tumor Therapy: State-of-the-Art and Future Prospects

edited by

Maria Virtudes Céspedes

submission deadline 30 Jun 2025 | Viewed by 157 | Submission Open

Keywords: nano-based cancer therapy; personalized nanoparticle; cancer care strategies; tumor treatment

The Impact of Epigenetic Reprogramming Induced by Environmental Factors on Aging

edited by

Min Hi Park

submission deadline 30 Jun 2025 | Viewed by 108 | Submission Open

Keywords: aging ; environmental factors ; DNA methylation ; histone modification ; non-coding RNA

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1600 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

PARPs in Cell Death and PARP Inhibitors in Cancers: 2nd Edition

edited by

María Isabel Rodríguez

and

Josefa León

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1506 | Submission Open

Keywords: PARPs; PARP inhibitors; cancers; cell death; DNA repair

(This special issue belongs to the Section Molecular Medicine)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 6749 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jul 2025 | Viewed by 183 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jul 2025 | Viewed by 178 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 15 Jul 2025 | Viewed by 131 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

(This special issue belongs to the Section Molecular Medicine)

Immune Responses in Type 1 Diabetes

edited by