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9.2
4.8
Journals
Biomolecules
Special Issues
Current Advances of Metal Complexes for Biomedical Applications
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Current Advances of Metal Complexes for Biomedical Applications

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 462

Special Issue Editors

Prof. Dr. Marcelino Maneiro

E-Mail Website
Guest Editor
Department of Inorganic Chemistry, Faculty of Sciences, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Interests: bioinorganic; biomimetic catalysts; supramolecular; superoxide dismutase; catalase; peroxidase; artificial photosynthesis
Special Issues, Collections and Topics in MDPI journals
Dr. Sandra Fernández-Fariña

E-Mail Website
Guest Editor
Gunnlaugsson Group, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland
Interests: creating metallosupramolecular helicates from d- and f-metal ions

Special Issue Information

Dear Colleagues,

Most biomolecules have charge-donating atoms that are capable of binding to metal ions and forming coordination complexes. One of the areas of development in bioinorganic chemistry is the study of the active centers of numerous enzymes, which, from a chemical point of view, are formally known as coordination compounds or metal complexes. One example is the series of enzymes in our antioxidant defense system: superoxide dismutases, catalases, glutathione peroxidases, and thioredoxin reductases.

Understanding the role of metal ions in these types of biological systems has led to a shift in focus, moving beyond initial classical ideas related to their toxicity to highlight their active role in regulating various metabolic processes. In this context, interest in the biomedical applications of metal complexes has developed.

This Special Issue aims to collate the current advances in this area, including both the study of different complexes as potential supplements to regulate the activity of some natural enzymes with metal centers, and the activity of metal complexes against various diseases, such as cancer, inflammation-related pathologies, or bacterial or viral infections. This Special Issue on metal complexes for biomedical applications also encompasses the development status of different compounds of this type as disease diagnostic tools, as they can act as nuclear imaging or contrast agents.

We look forward to receiving your valuable contributions to this Special Issue.

Prof. Dr. Marcelino Maneiro
Dr. Sandra Fernández-Fariña
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal complexes
  • metals in medicine
  • bioinorganic
  • anti-cancer
  • antiviral
  • anti-inflammatory
  • antioxidant
  • imaging applications

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Published Papers (1 paper)

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18 pages, 1330 KiB  
Review
Metallothionein and Other Factors Influencing Cadmium-Induced Kidney Dysfunction: Review and Commentary
by Gunnar F. Nordberg and Monica Nordberg
Biomolecules 2025, 15(8), 1083; https://doi.org/10.3390/biom15081083 - 26 Jul 2025
Viewed by 289
Abstract
Cadmium is widely recognized as an important environmental toxicant that may give rise to kidney dysfunction, bone disease, and cancer in humans and animals. Kidney dysfunction occurs at very low exposures and is often considered as the most sensitive or critical effect. Cadmium [...] Read more.
Cadmium is widely recognized as an important environmental toxicant that may give rise to kidney dysfunction, bone disease, and cancer in humans and animals. Kidney dysfunction occurs at very low exposures and is often considered as the most sensitive or critical effect. Cadmium exposures of concern occur in many countries. In low- and middle-income countries with small-scale mining, excessive exposure to cadmium and other metals occurs in occupational and environmental settings. This is of particular importance in view of the growing demand for metals in global climate change mitigation. Since the 1970s, the present authors have contributed evidence concerning the role of metallothionein and other factors in influencing the toxicokinetics and toxicity of cadmium, particularly as it relates to the development of adverse effects on kidneys in humans and animals. The findings gave a background to the development of biomarkers employed in epidemiological studies, demonstrating the important role of metallothionein in protection against cadmium-induced kidney dysfunction in humans. Studies in cadmium-exposed population groups demonstrated how biomarkers of kidney dysfunction changed during 8 years after drastic lowering of environmental cadmium exposure. Other epidemiological studies showed the impact of a good zinc status in lowering the prevalence of cadmium-related kidney dysfunction. Increased susceptibility to Cd-induced kidney dysfunction was shown in a population with high exposure to inorganic arsenic when compared with a group with low such exposure. Several national and international organizations have used part of the reviewed information, but the metallothionein-related biomarkers and the interaction effects have not been fully considered. We hope that these data sets will also be included and improve risk assessments and preventive measures. Full article
(This article belongs to the Special Issue Current Advances of Metal Complexes for Biomedical Applications)
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