Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Bioactive Compounds from Microalgae submission deadline 15 Sep 2025 | Viewed by 84 | Submission Open
Keywords: microalgae; bioactive compounds; biomolecules; innovations
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Sep 2025 | Viewed by 305 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience
edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim
submission deadline 30 Sep 2025 | 10 articles | Viewed by 22911 | Submission Open
Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology
(This special issue belongs to the Section Molecular Biology)
Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies
edited by and
submission deadline 30 Sep 2025 | 8 articles | Viewed by 18022 | Submission Open
Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy
(This special issue belongs to the Section Molecular Medicine)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 15500 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Prebiotics and Probiotics in Health and Disease: Looking at the Future submission deadline 30 Sep 2025 | 8 articles | Viewed by 15119 | Submission Open
Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics
(This special issue belongs to the Section Molecular Medicine)
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 7 articles | Viewed by 11351 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Amyloid-Beta and Alzheimer’s Disease submission deadline 30 Sep 2025 | 6 articles | Viewed by 9896 | Submission Open
Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD
(This special issue belongs to the Section Cellular Biochemistry)
Pathogenesis and Neuropathology of Alzheimer's Disease submission deadline 30 Sep 2025 | 7 articles | Viewed by 8253 | Submission Open
Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System
edited by Peng Yao and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 6795 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by Riccardo Fesce
submission deadline 30 Sep 2025 | 1 articles | Viewed by 5679 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 5165 | Submission Open
Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Mitochondria and Central Nervous System Disorders: 3rd Edition submission deadline 30 Sep 2025 | 3 articles | Viewed by 4280 | Submission Open
Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system
(This special issue belongs to the Section Molecular Biology)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3902 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Cellular Quiescence and Dormancy
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 3250 | Submission Open
Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva
(This special issue belongs to the Section Molecular Genetics)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 30 Sep 2025 | 1 articles | Viewed by 3168 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
Lipids Metabolism in Cardiovascular Disease
edited by Anand K. Rohatgi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3062 | Submission Open
Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis
(This special issue belongs to the Section Molecular Medicine)
Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition submission deadline 30 Sep 2025 | 4 articles | Viewed by 2842 | Submission Open
Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis
(This special issue belongs to the Section Molecular Biomarkers)
Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges submission deadline 30 Sep 2025 | 2 articles | Viewed by 2113 | Submission Open
Keywords: biomarker; molecular biology; bioinformatics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
New Insights into Protein Aggregation in Condensed and Amyloid States
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1887 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Mechanisms and Therapeutic Targets in Leukaemia
edited by and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1591 | Submission Open
Keywords: leukaemia; blood; genetics; genomics; chromosome
(This special issue belongs to the Section Molecular Medicine)
Stem Cells in Musculoskeletal Tissue Engineering
edited by and
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1529 | Submission Open
Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs
(This special issue belongs to the Section Bio-Engineered Materials)
Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition
edited by Jasmina Dimitrić Marković, and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1132 | Submission Open
Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery
Role of Postbiotics on Health Maintenance and Recovery
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1066 | Submission Open
Keywords: human microbiota; postbiotics; lantibiotics; SCFAs; SCFAs receptors; immune regulation; synbiotics; psychobiotics; dysbiosis; TMAO
(This special issue belongs to the Section Molecular Biology)
Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)
edited by and Alexander John Dear
submission deadline 30 Sep 2025 | 2 articles | Viewed by 991 | Submission Open
Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Cancer Epigenetics, Post-Translational Modification, and Drug Discovery
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 630 | Submission Open
Keywords: cancer; drug Discovery; epigenetics; inflammation; NF– κ B
(This special issue belongs to the Section Cellular Biochemistry)
State of the Art and Perspectives in Retinal Pigment Epithelium submission deadline 30 Sep 2025 | Viewed by 565 | Submission Open
Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy
(This special issue belongs to the Section Cellular Biochemistry)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2025 | 1 articles | Viewed by 559 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies
edited by
submission deadline 30 Sep 2025 | Viewed by 504 | Submission Open
Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Genetics of Human Disease
edited by and Ata Abbas
submission deadline 30 Sep 2025 | 1 articles | Viewed by 482 | Submission Open
Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication
(This special issue belongs to the Section Molecular Genetics)
DNA Damage and Repair in Cancer Treatment submission deadline 30 Sep 2025 | Viewed by 210 | Submission Open
Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis
(This special issue belongs to the Section Molecular Biology)
Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics submission deadline 30 Sep 2025 | Viewed by 204 | Submission Open
Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics
(This special issue belongs to the Section Molecular Genetics)
Omics in Entomology: Unraveling the Molecular Mechanisms of Insects submission deadline 30 Sep 2025 | Viewed by 155 | Submission Open
Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics
(This special issue belongs to the Section Molecular Genetics)
Extracellular Vesicles and Their Roles in Cancer Progression submission deadline 30 Sep 2025 | Viewed by 145 | Submission Open
Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers
(This special issue belongs to the Section Molecular Biology)
New Insights into Hormonal Control of Plant Growth and Development
edited by
submission deadline 30 Sep 2025 | Viewed by 117 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Molecular Biology)
Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies
edited by
submission deadline 30 Sep 2025 | Viewed by 112 | Submission Open
Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies
(This special issue belongs to the Section Molecular Medicine)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Sep 2025 | Viewed by 105 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics
edited by
submission deadline 30 Sep 2025 | Viewed by 104 | Submission Open
Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics  
(This special issue belongs to the Section Cellular Biochemistry)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Sep 2025 | Viewed by 101 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Cell Death and Clearance
edited by and Jascinta Santavanond
submission deadline 30 Sep 2025 | Viewed by 99 | Submission Open
Keywords: cell death; apoptosis; efferocytosis; cell clearance
(This special issue belongs to the Section Molecular Medicine)
Advances in Microbial CRISPR Editing
edited by and Rongming Liu
submission deadline 30 Sep 2025 | Viewed by 86 | Submission Open
Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems
(This special issue belongs to the Section Molecular Biology)
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Sep 2025 | Viewed by 74 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Sep 2025 | Viewed by 63 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
The Role and Metabolism of Metals in Cancer submission deadline 30 Sep 2025 | Viewed by 62 | Submission Open
Keywords: metals; cancer; cancer metabolism
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms of Human Skin Aging
edited by
submission deadline 15 Oct 2025 | 4 articles | Viewed by 12244 | Submission Open
Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention
(This special issue belongs to the Section Molecular Medicine)
Regulation of Synapses in the Brain
edited by and Guohao Wang
submission deadline 15 Oct 2025 | Viewed by 108 | Submission Open
Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions
Mechanisms of RNA Regulation in Inflammation
edited by
submission deadline 15 Oct 2025 | Viewed by 58 | Submission Open
Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Genetics)
Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications submission deadline 16 Oct 2025 | Viewed by 77 | Submission Open
Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation
(This special issue belongs to the Section Chemical Biology)
Molecular Biomarkers of Epileptogenesis
edited by Pedro J. Serrano-Castro
submission deadline 20 Oct 2025 | 3 articles | Viewed by 4311 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting
edited by and
submission deadline 22 Oct 2025 | Viewed by 65 | Submission Open
Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress
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