Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Genetics of Parasitic Protozoa submission deadline 28 Feb 2026 | Viewed by 134 | Submission Open
Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health
(This special issue belongs to the Section Molecular Genetics)
Photosynthetic Adaptation and Photoprotection in Plants
edited by
submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open
Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies submission deadline 14 Mar 2026 | 2 articles | Viewed by 884 | Submission Open
Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases
edited by Kristina Seiffert-Sinha and Animesh A. Sinha
submission deadline 15 Mar 2026 | 2 articles | Viewed by 1609 | Submission Open
Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Bronchiolitis Obliterans
edited by Ralf Schubert and Silvija-Pera Jerkic
submission deadline 15 Mar 2026 | Viewed by 123 | Submission Open
Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms
(This special issue belongs to the Section Molecular Medicine)
Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 1812 | Submission Open
Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants
(This special issue belongs to the Section Natural and Bio-derived Molecules)
DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways
edited by
submission deadline 20 Mar 2026 | Viewed by 236 | Submission Open
Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy
(This special issue belongs to the Section Molecular Biology)
Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health submission deadline 20 Mar 2026 | Viewed by 209 | Submission Open
Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems
The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics
edited by Gregory F. Oxenkrug
submission deadline 27 Mar 2026 | Viewed by 145 | Submission Open
Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation
(This special issue belongs to the Section Biological Factors)
Research Progress on Anti-Aging with Natural Products
edited by
submission deadline 29 Mar 2026 | 2 articles | Viewed by 3322 | Submission Open
Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications
(This special issue belongs to the Section Biological Factors)
Advances in Lysosomal Disorders: From Molecular Mechanisms to Diagnosis
edited by and Irene Capelli
submission deadline 29 Mar 2026 | Viewed by 107 | Submission Open
Keywords: Fabry disease; lysosomal disorders; globotriaosylceramide (GB3); inherited disease; GLA-gene; nephropathy; hypertrophic cardiomyopathy; small fiber neuropathy
(This special issue belongs to the Section Molecular Medicine)
Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)
edited by , , Jean Martin Beaulieu and Stephen S.G. Ferguson
submission deadline 31 Mar 2026 | 16 articles | Viewed by 65694 | Submission Open
Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR
(This special issue belongs to the Section Biological Factors)
Esophageal Diseases: Molecular Basis and Therapeutic Approaches
edited by and Amanda B. Muir
submission deadline 31 Mar 2026 | 6 articles | Viewed by 18032 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
The Role of Astrocytes in Neurodegenerative Diseases
edited by
submission deadline 31 Mar 2026 | 4 articles | Viewed by 14587 | Submission Open
Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases
edited by
submission deadline 31 Mar 2026 | 6 articles | Viewed by 12441 | Submission Open
Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy
(This special issue belongs to the Section Biological Factors)
State of the Art and Perspectives in Retinal Pigment Epithelium submission deadline 31 Mar 2026 | 4 articles | Viewed by 11033 | Submission Open
Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy
(This special issue belongs to the Section Cellular Biochemistry)
Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition
edited by and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 8324 | Submission Open
Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus
(This special issue belongs to the Section Molecular Medicine)
Molecular Advances in Drug Resistance and Novel Therapies for Cancer submission deadline 31 Mar 2026 | 5 articles | Viewed by 8119 | Submission Open
Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles
(This special issue belongs to the Section Biological Factors)
Novel Antimicrobial Strategies for Animal Health submission deadline 31 Mar 2026 | 2 articles | Viewed by 8014 | Submission Open
Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease
(This special issue belongs to the Section Molecular Medicine)
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier submission deadline 31 Mar 2026 | 3 articles | Viewed by 7894 | Submission Open
Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy
(This special issue belongs to the Section Bio-Engineered Materials)
The Role of Glycosaminoglycans and Proteoglycans in Human Disease
edited by
submission deadline 31 Mar 2026 | 4 articles | Viewed by 5400 | Submission Open
Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules
(This special issue belongs to the Section Molecular Biology)
Stem Cells in Musculoskeletal Tissue Engineering
edited by and
submission deadline 31 Mar 2026 | 2 articles | Viewed by 4890 | Submission Open
Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs
(This special issue belongs to the Section Bio-Engineered Materials)
Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies submission deadline 31 Mar 2026 | 1 articles | Viewed by 3827 | Submission Open
Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine
(This special issue belongs to the Section Molecular Genetics)
New Discoveries in the Field of Neuropharmacology
edited by and Bogdan Amuzescu
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3637 | Submission Open
Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp
(This special issue belongs to the Section Molecular Medicine)
Advances in Glycosaminoglycans (GAGs) and Mimetics submission deadline 31 Mar 2026 | 2 articles | Viewed by 2958 | Submission Open
Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins
(This special issue belongs to the Section Chemical Biology)
Advanced Therapeutic Strategies for Hormone-Dependent Cancers submission deadline 31 Mar 2026 | 1 articles | Viewed by 1771 | Submission Open
Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers
(This special issue belongs to the Section Molecular Medicine)
Updates on Molecular Mechanisms of Lysosomal Storage Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 1746 | Submission Open
Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD
(This special issue belongs to the Section Biological Factors)
Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies submission deadline 31 Mar 2026 | 2 articles | Viewed by 1692 | Submission Open
Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion
(This special issue belongs to the Section Molecular Medicine)
Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1568 | Submission Open
Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Extracellular Vesicles and Their Roles in Cancer Progression submission deadline 31 Mar 2026 | 1 articles | Viewed by 1423 | Submission Open
Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers
(This special issue belongs to the Section Molecular Biology)
From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 820 | Submission Open
Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 662 | Submission Open
Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications
(This special issue belongs to the Section Molecular Genetics)
Molecular Advances in Stress Response, Growth, Development, and Breeding of Horticultural Crops
edited by , and Jian Lyu
submission deadline 31 Mar 2026 | 1 articles | Viewed by 648 | Submission Open
Keywords: horticultural crops; multi-omics integration; genome editing; molecular plant breeding; abiotic and biotic stress; quality; metabolic pathways; plant hormones; transcriptional and epigenetic regulation; protein interaction networks
(This special issue belongs to the Section Biological Factors)
Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 608 | Submission Open
Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics
Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches submission deadline 31 Mar 2026 | 1 articles | Viewed by 527 | Submission Open
Keywords: obesity; causes; therapy; epigenetics; biomolecules
Amino Acids and Their Metabolism in Disease
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 521 | Submission Open
Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation submission deadline 31 Mar 2026 | 1 articles | Viewed by 404 | Submission Open
Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets
Tissue-Specific Organelle Dynamics submission deadline 31 Mar 2026 | Viewed by 400 | Submission Open
Keywords: organelles crosstalk; organelles contact sites; organelle dynamics
(This special issue belongs to the Section Cellular Biochemistry)
Fibrinogen and Fibrin in Human Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 278 | Submission Open
Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis
(This special issue belongs to the Section Molecular Biology)
Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications
edited by Yanzhong Yang
submission deadline 31 Mar 2026 | Viewed by 259 | Submission Open
Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor
(This special issue belongs to the Section Molecular Genetics)
Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement submission deadline 31 Mar 2026 | Viewed by 227 | Submission Open
Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance
Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential
edited by Umesh Kumar Jinwal
submission deadline 31 Mar 2026 | Viewed by 204 | Submission Open
Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Genetics and Molecular Mechanisms of Parkinson's Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 193 | Submission Open
Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration
(This special issue belongs to the Section Molecular Genetics)
Structure, Molecular Dynamics, Assembly, and Evolution of Protein Systems with AI-Enhanced Modeling in Pharmacology and Structural Biology submission deadline 31 Mar 2026 | Viewed by 160 | Submission Open
Keywords: machine learning in structural biology; molecular dynamics simulations; protein– ligand interactions; computational pharmacology; structure-based drug design
(This special issue belongs to the Section Molecular Biology)
The Role of Heparin in Blood
edited by , and Denisa Cont
submission deadline 31 Mar 2026 | Viewed by 159 | Submission Open
Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)
(This special issue belongs to the Section Molecular Medicine)
Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior submission deadline 31 Mar 2026 | Viewed by 158 | Submission Open
Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration
(This special issue belongs to the Section Chemical Biology)
Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension
edited by and Grégoire Ruffenach
submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open
Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches
(This special issue belongs to the Section Molecular Medicine)
Post-Translational Modifications in Disease: From Computational Prediction to Functional Mechanisms
edited by
submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open
Keywords: post-translational modifications; PTMs; disease
SAM Domains in Health and Diseases: Structural and Functional Insights submission deadline 31 Mar 2026 | Viewed by 135 | Submission Open
Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Fibronectin, Integrins and Related Molecules in Health and Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 117 | Submission Open
Keywords: integrin; fibronectin; cytokines
(This special issue belongs to the Section Chemical Biology)
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