Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Astrocytes in Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2025 | 4 articles | Viewed by 4297 | Submission Open
Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration
(This special issue belongs to the Section Cellular Biochemistry)
The Role of CD36 in Human Health and Disease
edited by and Mihail E. Hinescu
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2991 | Submission Open
Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker
(This special issue belongs to the Section Molecular Medicine)
Genomics in Biodiversity Conservation (Vertebrates and Invertebrates) submission deadline 31 Aug 2025 | 2 articles | Viewed by 2397 | Submission Open
Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution
(This special issue belongs to the Section Molecular Genetics)
New Insights into Forensic Molecular Genetics
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2279 | Submission Open
Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome
(This special issue belongs to the Section Molecular Genetics)
New Insights into RNA-Binding Proteins
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2267 | Submission Open
Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action
edited by Chandra Mishra and
submission deadline 31 Aug 2025 | 2 articles | Viewed by 2130 | Submission Open
Keywords: heterocyclic compounds; anticancer; synthetic; natural
(This special issue belongs to the Section Molecular Medicine)
Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs
edited by Tatiana V. Lipina
submission deadline 31 Aug 2025 | 1 articles | Viewed by 2091 | Submission Open
Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R; neurodevelopment; neurotransmission; synaptic plasticity; neural circuits; genomics; proteomics; intracellular signalling; bioenergetics; prevention
(This special issue belongs to the Section Molecular Biology)
Glutamate and Glutamate Receptors in Health and Diseases, Second Edition submission deadline 31 Aug 2025 | 2 articles | Viewed by 1975 | Submission Open
Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration
(This special issue belongs to the Section Molecular Biology)
Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1945 | Submission Open
Keywords: nerve conduction; action potential; clinical drug; medicinal plant compound; voltage-gated ion channel
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1431 | Submission Open
Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy
(This special issue belongs to the Section Biological Factors)
Molecular Mechanisms and Pathophysiology of Gliomas
edited by Fengchao Lang
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1168 | Submission Open
Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies
(This special issue belongs to the Section Molecular Biology)
New Insights into Autacoids in Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 946 | Submission Open
Keywords: angiotensin; bradykinin; endothelin; prostaglandins; thromboxanes; leukotrienes; serotonin; histamine; angiotensin-converting enzyme; angiotensin receptor; renin; kininogen; kallikrein; cyclooxygenase; phospholipase A2
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition
edited by , Alessandra Andrisani and Chiara Sabbadin
submission deadline 31 Aug 2025 | 1 articles | Viewed by 820 | Submission Open
Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Protein X-Ray Crystallography
edited by Wu-Pei Su and
submission deadline 31 Aug 2025 | 1 articles | Viewed by 655 | Submission Open
Keywords: ab initio phasing methods; X-ray crystallography; protein structural determination; image reconstruction from Fourier amplitudes; iterative projection algorithms; phasing with deep learning methods
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Bioactive Compounds as Modifiers of Mitochondrial Function
edited by Mihail "Mike" Mitov
submission deadline 31 Aug 2025 | Viewed by 581 | Submission Open
Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Tumor Genomics and Liquid Biopsy in Cancer Biology
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 577 | Submission Open
Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration
(This special issue belongs to the Section Molecular Biology)
Applications of NMR Spectroscopy in Structure-Based Drug Discovery
edited by Alexander L. Breeze and Reto Walser
submission deadline 31 Aug 2025 | Viewed by 473 | Submission Open
Keywords: NMR; structural biology; structure-based drug discovery; fragment screening; lead generation
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases
edited by Ricardo Rodrigues
submission deadline 31 Aug 2025 | Viewed by 327 | Submission Open
Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases
(This special issue belongs to the Section Molecular Biology)
Biomolecular Sciences and Precision Medicine in Vascular Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 273 | Submission Open
Keywords: precision medicine; vascular disease; vascular surgery
(This special issue belongs to the Section Molecular Medicine)
Regenerative Medicine in Wound Healing and Tissue Engineering
edited by
submission deadline 31 Aug 2025 | Viewed by 168 | Submission Open
Keywords: wound healing; regeneration medicine; tissue engineering
Oxidative Stress and Ferroptosis in Health and Disease
edited by Udayakumar Karunakaran and Suma Elumalai
submission deadline 31 Aug 2025 | Viewed by 162 | Submission Open
Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases
(This special issue belongs to the Section Chemical Biology)
Probiotics and Their Metabolites, 2nd Edition submission deadline 31 Aug 2025 | Viewed by 152 | Submission Open
Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Cellular and Molecular Mechanisms in Cardiorenal Syndrome
edited by , María Carmen Ruiz Fuentes and Maria José Espigares Huete
submission deadline 31 Aug 2025 | Viewed by 147 | Submission Open
Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure
(This special issue belongs to the Section Molecular Biology)
Small Aquatic Organisms as a Model for Predictive Toxicology and Stress Mechanisms
edited by Tetsuhiro Kudoh
submission deadline 31 Aug 2025 | Viewed by 126 | Submission Open
Keywords: fish model; zebrafish model; chemical toxicology
DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways
edited by
submission deadline 31 Aug 2025 | Viewed by 98 | Submission Open
Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy
(This special issue belongs to the Section Molecular Biology)
Updates on Molecular Mechanisms of Lysosomal Storage Disease submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open
Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD
(This special issue belongs to the Section Biological Factors)
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition
edited by
submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advances in Antiviral Drug Development
edited by Angel S. Galabov
submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open
Keywords: viral inhibitors; mechanism of action; antiviral tests
(This special issue belongs to the Section Molecular Medicine)
Genetics and Molecular Mechanisms of Parkinson's Disease
edited by
submission deadline 31 Aug 2025 | Viewed by 68 | Submission Open
Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration
(This special issue belongs to the Section Molecular Genetics)
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier submission deadline 15 Sep 2025 | 1 articles | Viewed by 2916 | Submission Open
Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy
(This special issue belongs to the Section Bio-Engineered Materials)
Roles of Alpha-1 Antitrypsin in Human Health and Disease Models
edited by
submission deadline 15 Sep 2025 | 2 articles | Viewed by 2265 | Submission Open
Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases
edited by Kristina Seiffert-Sinha and Animesh A. Sinha
submission deadline 15 Sep 2025 | Viewed by 377 | Submission Open
Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Bioactive Compounds from Microalgae submission deadline 15 Sep 2025 | Viewed by 79 | Submission Open
Keywords: microalgae; bioactive compounds; biomolecules; innovations
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Sep 2025 | Viewed by 303 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Early Adversity and the Immune Hypothesis: Call for a Dialogue between Basic and Clinical Neuroscience
edited by Arie Kaffman, Kate Ryan Kuhlman, Bridget L. Callaghan and Christine Heim
submission deadline 30 Sep 2025 | 10 articles | Viewed by 22896 | Submission Open
Keywords: early adversity; microglia; neuroinflammation; microbiome; psychopathology
(This special issue belongs to the Section Molecular Biology)
Diabetes, Overweight and Obesity: From Molecular Mechanisms to Therapies Strategies
edited by and
submission deadline 30 Sep 2025 | 8 articles | Viewed by 17999 | Submission Open
Keywords: diabetes mellitus; overweight; obesity; molecular mechanisms; microbiome; liver metabolism; advanced therapy
(This special issue belongs to the Section Molecular Medicine)
Molecular Aspects of Diseases Origin and Development
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 15492 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Prebiotics and Probiotics in Health and Disease: Looking at the Future submission deadline 30 Sep 2025 | 8 articles | Viewed by 15104 | Submission Open
Keywords: probiotics; live biotherapeutic product (LBP); next-generation probiotic (NGP); prebiotic; synbiotic/symbiotic; pharmabiotics; post-biotics; paraprobiotic/ghost probiotics/inactivated probiotics; probioceuticals/probiotaceuticals; biogenic; gut balance; gut– brain axis; vaginal homeostasis; vaginal microbiota modification or augmentation; oral microbiota; skin microbiota; new therapeutic approaches using bacteria; psychobiotics
(This special issue belongs to the Section Molecular Medicine)
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 30 Sep 2025 | 7 articles | Viewed by 11339 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
Amyloid-Beta and Alzheimer’s Disease submission deadline 30 Sep 2025 | 6 articles | Viewed by 9887 | Submission Open
Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD
(This special issue belongs to the Section Cellular Biochemistry)
Pathogenesis and Neuropathology of Alzheimer's Disease submission deadline 30 Sep 2025 | 7 articles | Viewed by 8242 | Submission Open
Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System
edited by Peng Yao and
submission deadline 30 Sep 2025 | 5 articles | Viewed by 6791 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Medicine)
The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research
edited by Riccardo Fesce
submission deadline 30 Sep 2025 | 1 articles | Viewed by 5675 | Submission Open
Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Health and Environmental Effect of Advanced Materials and Fine Particles: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 5159 | Submission Open
Keywords: advanced materials; fine particles; nanoparticles; nanomaterials; ultrafine particles; health effect; environmental effect; risk assessment; toxicity; exposure; biomaterials
(This special issue belongs to the Section Molecular Medicine)
Mitochondria and Central Nervous System Disorders: 3rd Edition submission deadline 30 Sep 2025 | 3 articles | Viewed by 4271 | Submission Open
Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system
(This special issue belongs to the Section Molecular Biology)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3897 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
(This special issue belongs to the Section Biological Factors)
Cellular Quiescence and Dormancy
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3234 | Submission Open
Keywords: quiescent cells; dormant cells; biostasis; diapause; spores; dauer larva
(This special issue belongs to the Section Molecular Genetics)
Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders submission deadline 30 Sep 2025 | 1 articles | Viewed by 3165 | Submission Open
Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration
(This special issue belongs to the Section Molecular Medicine)
Lipids Metabolism in Cardiovascular Disease
edited by Anand K. Rohatgi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 3061 | Submission Open
Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis
(This special issue belongs to the Section Molecular Medicine)
Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition submission deadline 30 Sep 2025 | 4 articles | Viewed by 2838 | Submission Open
Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis
(This special issue belongs to the Section Molecular Biomarkers)
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