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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1648 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression

edited by

Kiyoshi Ohtani

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1620 | Submission Open

Keywords: E2F; RB; p53; cancer; tumor suppression

(This special issue belongs to the Section Biological Factors)

Novel Molecules for Cancer Treatment (3rd Edition)

edited by

Javier Martínez Useros

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1497 | Submission Open

Keywords: cancer; small molecules; antibody-drug-conjugated; tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immunotherapy; natural compounds

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 30 Jun 2025 | 1 articles | Viewed by 986 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Protein Self-Assembly in Diseases and Function

edited by

Anoop Arunagiri

, Srivastav Ranganathan and Maria del Carmen Fernandez Ramirez

submission deadline 30 Jun 2025 | 1 articles | Viewed by 662 | Submission Open

Keywords: protein folding; protein aggregation; amyloids; biomolecular condensates

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 30 Jun 2025 | Viewed by 455 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Regeneration of Annelids: From Reorganization of Lost Body Parts to Cellular and Molecular Biological Background

edited by

László Molnár

submission deadline 30 Jun 2025 | Viewed by 413 | Submission Open

Keywords: regeneration; body plan; dedifferentiation; stem cells; morphallaxis; epimorphosis; neuro-immune interactions

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Biomolecular Research: Selected Papers from the 2024 Biomedical Sciences Symposium

edited by Yuri Nesmelov and Jun-Tao Guo

submission deadline 30 Jun 2025 | Viewed by 315 | Submission Open

Keywords: cancer biology; regenerative medicine; infectious disease; artificial intelligence in health research; nanomaterials; drug design

Metabolic Inflammation and Insulin Resistance in Obesity

edited by Bingxian Xie

submission deadline 30 Jun 2025 | Viewed by 274 | Submission Open

Keywords: obesity-linked inflammation; insulin resistance; adipose tissue

(This special issue belongs to the Section Lipids)

Advances in Computational Approaches for the Discovery of Therapeutics and Personalized Medicine

edited by

Supriyo Bhattacharya

submission deadline 30 Jun 2025 | Viewed by 238 | Submission Open

Keywords: high-throughput virtual screening; CADD; machine learning; biologics design; off-target effect prediction

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Mechanosensitivity and Ion Channels

edited by Olivia García-Suarez and Yolanda García-Mesa

submission deadline 30 Jun 2025 | Viewed by 231 | Submission Open

Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 30 Jun 2025 | Viewed by 213 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Molecular Interactions between Obesity and Breast Cancer

edited by Fokhrul Hossain

submission deadline 30 Jun 2025 | Viewed by 210 | Submission Open

Keywords: breast cancer; breast cancer subtypes; triple-negative breast cancer; obesity; molecular mechanisms; molecular interactions

(This special issue belongs to the Section Molecular Medicine)

Regulation Mechanisms of Autophagy in Aging

edited by

Patricia Gomez-Suaga

submission deadline 30 Jun 2025 | Viewed by 184 | Submission Open

Keywords: autophagy; cellular senescence; protein aggregation; mitochondrial dysfunction; aging

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Nano-Based Drug Delivery Systems

edited by

Amalendu P. Ranjan

Nirupama A. Sabnis

and

Zacharias Suntres

submission deadline 30 Jun 2025 | Viewed by 166 | Submission Open

Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules

(This special issue belongs to the Section Molecular Medicine)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 30 Jun 2025 | Viewed by 164 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Jun 2025 | Viewed by 152 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 30 Jun 2025 | Viewed by 142 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Nano-Based Tumor Therapy: State-of-the-Art and Future Prospects

edited by

Maria Virtudes Céspedes

submission deadline 30 Jun 2025 | Viewed by 141 | Submission Open

Keywords: nano-based cancer therapy; personalized nanoparticle; cancer care strategies; tumor treatment

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 30 Jun 2025 | Viewed by 136 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 30 Jun 2025 | Viewed by 136 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 30 Jun 2025 | Viewed by 135 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 30 Jun 2025 | Viewed by 125 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

The Impact of Epigenetic Reprogramming Induced by Environmental Factors on Aging

edited by

Min Hi Park

submission deadline 30 Jun 2025 | Viewed by 92 | Submission Open

Keywords: aging ; environmental factors ; DNA methylation ; histone modification ; non-coding RNA

Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies

edited by Peter W. Jurutka and

Todd R. Sandrin

submission deadline 1 Jul 2025 | 2 articles | Viewed by 3706 | Submission Open

Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology

(This special issue belongs to the Section Molecular Genetics)

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1420 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

PARPs in Cell Death and PARP Inhibitors in Cancers: 2nd Edition

edited by

María Isabel Rodríguez

and

Josefa León

submission deadline 10 Jul 2025 | 1 articles | Viewed by 1262 | Submission Open

Keywords: PARPs; PARP inhibitors; cancers; cell death; DNA repair

(This special issue belongs to the Section Molecular Medicine)

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signaling

edited by

Hans-Werner Denker

, Evdokia Dimitriadis and Lois A. Salamonsen

submission deadline 15 Jul 2025 | 4 articles | Viewed by 4574 | Submission Open

Keywords: embryo implantation; endometrial receptivity; trophoblast invasion; signaling

(This special issue belongs to the Section Molecular Reproduction)

Molecular Pathology, Diagnostics and Therapeutics of Retinal Diseases: 2nd Edition

edited by

Antonio Ferreras

submission deadline 15 Jul 2025 | Viewed by 157 | Submission Open

Keywords: retina; macula; macular edema; inflammatory mediators; optical coherence tomography; retinal imaging; biochemical marker; biomarker; pharmacological targeting

Muscular Dystrophy: From Molecular Basis to Therapies: 2nd Edition

edited by

Francesca Sciandra

and

Kinga I. Gawlik

submission deadline 15 Jul 2025 | Viewed by 149 | Submission Open

Keywords: muscular dystrophies; muscle regeneration; extracellular matrix; satellite cells; therapeutic approaches; animal models; clinical trials

Molecular Mechanisms, Novel Diagnostics and Treatments of Gynecologic Cancer

edited by Panneerdoss Subbarayalu

submission deadline 15 Jul 2025 | Viewed by 90 | Submission Open

Keywords: biomarker; cancer biology; novel drug targets and therapeutics; cancer stem cells; tumorigenesis

Immune Responses in Type 1 Diabetes

edited by

Eddie A. James

and Sally C. Kent

submission deadline 20 Jul 2025 | 4 articles | Viewed by 3403 | Submission Open

Keywords: type 1 diabetes; insulitis; immune response

(This special issue belongs to the Section Molecular Biology)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 21 Jul 2025 | Viewed by 275 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

(This special issue belongs to the Section Molecular Biology)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 25 Jul 2025 | 3 articles | Viewed by 3731 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Inflammatory Mechanisms and Molecular Targets in Neurological Disorders: Effects of Neuroprotective Drugs

edited by

Jose Joaquin Merino

submission deadline 30 Jul 2025 | Viewed by 310 | Submission Open

Keywords: neuroinflammation; neurological disorders; molecular targets; therapeutic strategies; neuroimmunology

(This special issue belongs to the Section Molecular Medicine)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Jul 2025 | 16 articles | Viewed by 45237 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Recent Developments in Mesenchymal Stem Cells

edited by

Antonietta Rosa Silini

and

Enrico Ragni

submission deadline 31 Jul 2025 | 8 articles | Viewed by 16991 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; secretome

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 2nd Edition

edited by

Adriana Georgescu

submission deadline 31 Jul 2025 | 6 articles | Viewed by 12130 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

(This special issue belongs to the Section Molecular Biology)

Mitochondrial ROS in Health and Disease

edited by

Frank Krause

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11940 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Therapeutic Potential of Natural Products in Metabolic Diseases

edited by

Atanas G. Atanasov

Ronan Lordan

and

Ren-You Gan

submission deadline 31 Jul 2025 | 4 articles | Viewed by 11004 | Submission Open

Keywords: natural products; metabolic disorders; diabetes mellitus; dietary constituents; phytotherapy; integrative medicine; obesity; dyslipidemia; non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH); nutraceuticals; supplements

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular, Cellular, and Blood Biomarkers in Diagnosis, Prognosis, Monitoring, and Treatment

edited by

Jordi Camps

, Isabel Fort Gallifa and Xavier Gabaldó Barrios

submission deadline 31 Jul 2025 | 6 articles | Viewed by 8800 | Submission Open

Keywords: biomarkers; infectious diseases; laboratory medicine; non-communicable diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Mechanism of Antipsychotic Drugs

edited by Serdar Dursun and

Massimo Tusconi

submission deadline 31 Jul 2025 | 2 articles | Viewed by 6534 | Submission Open

Keywords: psychotropic medications; antipsychotic drugs; schizophrenia; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction

edited by

Clement Agoni

and

Indrani Bera

submission deadline 31 Jul 2025 | 6 articles | Viewed by 6515 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein– protein interactions; protein– ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Advances in Inflammatory Bowel Disease

edited by

Antonietta Gerarda Gravina

and

Raffaele Pellegrino

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4829 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; quality of life; diagnostic markers; prognostic markers; drug monitoring; antibodies

(This special issue belongs to the Section Molecular Medicine)

Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho

edited by

João Pedro Silva

and

Vera Marisa Costa

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4814 | Submission Open

Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation

(This special issue belongs to the Section Molecular Medicine)

Cannabinoids in Neurobehavioral Modulation

edited by

Francisco Navarrete

and

María S. García Gutiérrez

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4678 | Submission Open

Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational

(This special issue belongs to the Section Molecular Biology)

Omics Data Integration: Focusing on Molecular Biomarkers for Cancers and Diseases

edited by Cinzia Franchin

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4175 | Submission Open

Keywords: omics data analysis; omics data integration; biomarker discovery; bioinformatics; cancers

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Cardiometabolic Health

edited by

Pamela Senesi

and

Anna Ferrulli

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3707 | Submission Open

Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Scaffold Proteins in Human Diseases

edited by László Buday and

Virag Vas

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3381 | Submission Open

Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1607 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

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