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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Roles of Glycosylation in Disease

edited by

Rudolf Tauber

and Véronique Blanchard

submission deadline 31 Jan 2027 | Viewed by 132 | Submission Open

Keywords: Glycomics; Glycosylation; Oligosaccharides; rare diseases; cancer; immunology; infection; structural analysis; therapeutic glycoproteins

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Astrocytes in Neurodegenerative Diseases: 2nd Edition

edited by

Nima Sanadgol

submission deadline 31 Jan 2027 | Viewed by 80 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models: 2nd Edition

edited by

Sihong Song

submission deadline 31 Jan 2027 | Viewed by 16 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Novel Treatments of Atherosclerosis

edited by

Vikrant Rai

submission deadline 10 Feb 2027 | Viewed by 184 | Submission Open

Keywords: atherosclerosis; plaque; plaque vulnerability; inflammation; immunomodulation; immune cells; multi-omics; imaging; management and therapeutics; targeted therapies

(This special issue belongs to the Section Lipids)

Purinergic Signalling in Disease and Inflammation

edited by Andréia Machado Cardoso

submission deadline 10 Feb 2027 | Viewed by 106 | Submission Open

Keywords: purinergic signalling; inflammation; ATP and adenosine; P1 receptors; P2 receptors; ectonucleotidases; chronic diseases; neurodegeneration; exercise physiology; translational research

(This special issue belongs to the Section Molecular Biology)

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2468 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Membrane Clusters in Health and Neurodegenerative Disease

edited by Tayuan Chang and Catherine C. Y. Chang

submission deadline 28 Feb 2027 | Viewed by 358 | Submission Open

Keywords: membrane cluster; membrane lipids; membrane proteins; caveolin; lipid rafts; phospholipid; cholesterol; sphingolipids; cholesteryl esters

Molecular Motors in Muscle: From Single Molecules to Tissue Function

edited by

Pasquale Bianco

submission deadline 28 Feb 2027 | Viewed by 276 | Submission Open

Keywords: molecular motors; muscle mechanics; motor protein energetics; cytoskeletal dynamics; single-molecule biophysics

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Ion Channels and Transporters in Immune Function and Inflammatory Disease

edited by Liang Hong and Lu Zhang

submission deadline 28 Feb 2027 | Viewed by 116 | Submission Open

Keywords: ion channel; immune regulation; electrophysiology; inflammation

(This special issue belongs to the Section Molecular Medicine)

Emerging Roles of Non-Coding RNAs in Gene Regulation and Disease

edited by

Laura Maria De Plano

and

Simona Taverna

submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open

Keywords: non-coding RNAs; gene expression regulation; miRNA-based therapeutics; translational RNA research

(This special issue belongs to the Section Molecular Biology)

New Discoveries in the Field of Neuropharmacology: 2nd Edition

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 28 Feb 2027 | Viewed by 40 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications

edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros

submission deadline 1 Mar 2027 | Viewed by 232 | Submission Open

Keywords: botanical bioactives; by-products; natural food additives; green extraction

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Signal Transduction and Pathway Regulation in Cancer

edited by

Carmen Cristina Diaconu

submission deadline 25 Mar 2027 | 3 articles | Viewed by 2550 | Submission Open

Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Molecular Biology)

Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

edited by

Virginia Tancredi

Roberto Bonanni

and

Ida Cariati

submission deadline 30 Mar 2027 | 3 articles | Viewed by 1479 | Submission Open

Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise

(This special issue belongs to the Section Biological Factors)

Nitric Oxide and Reactive Species in Plant Physiology and Pathology

edited by

Bong-Gyu Mun

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2609 | Submission Open

Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation

(This special issue belongs to the Section Biological Factors)

Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications

edited by

Simona Pergolizzi

and Anthea Miller

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2221 | Submission Open

Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)

(This special issue belongs to the Section Molecular Medicine)

Natural Compounds with Biomedical Potential

edited by

Irina Camelia Chis

and

Cristina Mariana Moldovan

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1005 | Submission Open

Keywords: natural compounds; naturat extracts; drug discovery; antimicrobial activity; antioxidant activity; anticancer activity; anti-inflammatory activity; anti-diabetes activity

(This special issue belongs to the Section Chemical Biology)

Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD

edited by Weber Andre Alberto

submission deadline 31 Mar 2027 | 1 articles | Viewed by 772 | Submission Open

Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in Structure-Based Inhibitor/Drug Design

edited by

Guoping Zhou

submission deadline 31 Mar 2027 | 1 articles | Viewed by 739 | Submission Open

Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)

Multifunctional Nanocarriers for Advanced Therapy and Diagnosis

edited by

Buddhadev Layek

submission deadline 31 Mar 2027 | 1 articles | Viewed by 616 | Submission Open

Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles

(This special issue belongs to the Section Bio-Engineered Materials)

Proteins Governing Genome Architecture and Gene Expression

edited by

Ilaria Baglivo

and

Remus Dame

submission deadline 31 Mar 2027 | 1 articles | Viewed by 299 | Submission Open

Keywords: regulatory proteins; genome architecture; gene regulation; chromatin dynamics; structural mechanisms; functional studies; protein– protein interaction; protein– DNA interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genetic Variations and Gene Expression in Diseases

edited by

Éva Kereszturi

submission deadline 31 Mar 2027 | Viewed by 246 | Submission Open

Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis

(This special issue belongs to the Section Molecular Biology)

Bone Injuries: New Pharmaceutical, Biomaterial and Therapies

edited by Xinlin Yang

submission deadline 31 Mar 2027 | Viewed by 179 | Submission Open

Keywords: bone regeneration; biomaterials; drug delivery; tissue engineering; stem cell therapy; osteogenesis; bone repair; regenerative medicine

Emerging Bioactive Compounds from Medicinal Plants

edited by Shiau Pin Tan and

Jose Maria Prieto-Garcia

submission deadline 31 Mar 2027 | Viewed by 67 | Submission Open

Keywords: bioactive compounds; medicinal plants; bioactivity mechanisms

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function

edited by

Keiko Kawauchi

and Tamaki Endoh

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2219 | Submission Open

Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Mesenchymal Stromal Cells in Regenerative Medicine and Immune Modulation: Mechanisms, Engineering, and Therapeutic Applications

edited by

Makram Merimi

submission deadline 30 Apr 2027 | Viewed by 191 | Submission Open

Keywords: mesenchymal stromal cells; immunomodulation; regenerative medicine; tumor microenvironment; cancer immunotherapy; extracellular vesicles; non‑coding RNAs; engineered MSCs; cell– cell communication

(This special issue belongs to the Section Cellular Biochemistry)

Protein Biophysics

edited by

Vladimir N. Uversky

and

Orkid Coskuner-Weber

submission deadline 31 May 2027 | 5 articles | Viewed by 8430 | Submission Open

Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Engineering and Applications of Protein Cages and Cavities

edited by

John F. Honek

submission deadline 31 May 2027 | Viewed by 292 | Submission Open

Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal; materials science; and analytical applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cellular and Molecular Basis of Metabolic Alterations in Transplantation

edited by

Valentina Vaira

and