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Biomolecules
Special Issues
Advanced Biomaterials for Healing Oral Tissues
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Advanced Biomaterials for Healing Oral Tissues

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 765

Special Issue Editors

Dr. Miki Taketomi Saito

E-Mail Website
Guest Editor
Graduate Program in Dentistry, Federal University of Pará, Augusto Correa Avenue, n. 1, Belém 66075-110, PA, Brazil
Interests: periodontal tissues; human stem cells; wound healing; regeneration; cellular biology; molecular biology
Dr. Rafael R. Lima

E-Mail Website
Guest Editor
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil
Interests: neurotoxicology; heavy metals; oxidative stress; excitotoxicity; inflammatory response; brain injury
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite the academic community to contribute to this Special Issue of the journal Biomolecules, entitled “Advanced Biomaterials for Healing Oral Tissues”.

This Special Issue aims to explore the biocompatibility and healing potential of biomaterials developed for oral procedures.

In recent years, numerous studies have found that neurotrophic or growth factors could be utilized as therapeutics in the treatment of a wide range of diseases.

Through this Special Issue, we aim to provide a comprehensive understanding of the potential application of biomaterials in tissue healing and regeneration and their clinical implications. In alignment with the journal's scope, we welcome the submission of those presenting in vitro, in vivo, and pre-clinical research that provides novel insights into the development of biomaterials for oral health.

We welcome innovative research that addresses the integration of chemistry, biology, and medical applications, and that collectively explores the application of biomaterials in oral health.

We look forward to receiving your submissions.

Dr. Miki Taketomi Saito
Dr. Rafael R. Lima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible materials
  • biopolymers
  • dental implants
  • materials testing
  • pharmaceutical preparations
  • regeneration
  • regenerative medicine
  • tissue scaffolds
  • wound healing

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Published Papers (1 paper)

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16 pages, 1588 KiB  
Perspective
Regenerative Strategies in Dentistry: Harnessing Stem Cells, Biomaterials and Bioactive Materials for Tissue Repair
by Vidhya Rekha Umapathy, Prabhu Manickam Natarajan and Bhuminathan Swamikannu
Biomolecules 2025, 15(4), 546; https://doi.org/10.3390/biom15040546 - 8 Apr 2025
Viewed by 651
Abstract
Advanced bioengineering, popularly known as regenerative dentistry, has emerged and is steadily developing with the aim of replacement of lost or injured tissues in the mouth using stem cells and other biomaterials. Conventional therapies for reparative dentistry, for instance fillings or crowns, mainly [...] Read more.
Advanced bioengineering, popularly known as regenerative dentistry, has emerged and is steadily developing with the aim of replacement of lost or injured tissues in the mouth using stem cells and other biomaterials. Conventional therapies for reparative dentistry, for instance fillings or crowns, mainly entail the replenishment of affected tissues without much concern given to the regeneration of tissues. However, these methods do not enable the natural function and aesthetics of the teeth to be maintained in the long term. There are several regenerative strategies that offer the potential to address these limitations to the extent of biologically restoring the function of teeth and their components, like pulp, dentin, bone, and periodontal tissues. Hence, stem cells, especially dental tissue derived stem cells, such as dental pulp stem cells, periodontal ligament stem cells, or apical papilla stem cells, are quite promising in this regard. These stem cells have the potentiality of generating precise dental cell lineages and thus are vital for tissue healing and renewal. Further, hydrogels, growth factors, and synthetic scaffolds help in supporting the stem cells for growth, proliferation, and differentiation into functional tissues. This review aims at describing the process of stem cell-based tissue repair biomaterials in dental regeneration, and also looks into the practice and prospects of regenerative dentistry, analysing several case reports and clinical investigations that demonstrate the efficacy and limitations of the technique. Nonetheless, the tremendous potential for regenerative dentistry is a reality that is currently challenged by biological and technical constraints, such as scarcity of stem cell sources, inadequate vascularization, and the integration of the materials used in the procedure. As we move forward, the prospects for regenerative dentistry are in subsequent developments of stem cell technology, biomaterial optimization, and individualized treatment methods, which might become increasingly integrated in dental practices globally. However, there are regulatory, ethical and economic issues that may pose a hurdle in the further advancement of this discipline. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Healing Oral Tissues)
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