Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 62
Special Issue Editors
Interests: immunology; inflammation; muscle damage; cytokine; leukocyte; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Regular physical activity profoundly influences immunometabolism, the intricate interplay between immune function and metabolic pathways. Exercise triggers biomolecular adaptations that regulate inflammation, cellular metabolism, and immune responses, leading to systemic benefits in disease prevention and treatment. Understanding the precise biomolecular mechanisms underlying these adaptations remains a critical area of research.
This Special Issue aims to highlight recent advances in understanding the biomolecular basis of exercise-induced immunometabolic modulation. By examining the biomolecular responses to exercise at the molecular and cellular levels, we aim to uncover novel insights into how physical activity influences biomolecular mechanisms underlying immune regulation, metabolic pathways, and their interplay in disease contexts, particularly in the regulation of metabolic disorders, cardiovascular diseases, inflammatory diseases, neurodegeneration and cancer.
We invite submissions focusing on, but not limited to, the following biomolecular aspects:
- Biomolecular Signaling in Exercise Adaptation: The role of key molecules (e.g., cytokines, metabolites, transcription factors) in mediating immunometabolic responses to exercise.
- Exercise and Immune Cell Metabolism: The impact of physical activity on immune cell bioenergetics, metabolic reprogramming, and functional plasticity.
- Inflammatory Pathways and Exercise: Molecular mechanisms by which exercise modulates chronic inflammation and immune cell activation.
- Mitochondrial Bioenergetics and Exercise: The role of exercise in mitochondrial function, oxidative stress regulation, and metabolic homeostasis in immune cells.
- Exercise and Adaptive Immunity: How physical activity influences T-cell metabolism, antigen presentation, and immune memory formation.
- Neuroimmunometabolism and Brain Health: Molecular pathways linking exercise to neuroinflammation, neuronal metabolism, and neuroprotection.
- Exercise and Cancer Immunometabolism: The role of physical activity in modulating the tumor microenvironment, immune surveillance, and metabolic programming of immune cells.
- Metabolic Biomarkers of Exercise-Induced Immunomodulation: Identification and characterization of molecular signatures reflecting exercise’s impact on immune-metabolic crosstalk.
This Special Issue will provide cutting-edge insights into the biomolecular aspects of exercise-induced immunometabolic regulation and its implications for disease management. We welcome high-quality submissions from researchers across disciplines, including molecular biology, immunology, metabolism, sports science, and clinical medicine.
We look forward to your contributions to this exciting Special Issue.
Prof. Dr. Katsuhiko Suzuki
Dr. Kayvan Khoramipour
Guest Editors
Manuscript Submission Information
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Keywords
- biomolecular signaling in exercise adaptation
- exercise and immune cell metabolism
- inflammatory pathways and exercise
- mitochondrial bioenergetics and exercise
- exercise and adaptive immunity
- neuroimmunometabolism and brain health
- exercise and cancer immunometabolism
- metabolic biomarkers of exercise-induced immunomodulation
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