Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

Dear Colleagues,

The rapid evolution of multi-omics technologies—spanning genomics, transcriptomics, proteomics, metabolomics, microbiomics, and associated genome editing tools—is providing unprecedented insights into the molecular foundations of agriculture. These approaches enable a systems-level understanding of the biomolecules, biochemical pathways, and molecular regulatory networks that govern key agricultural traits.

This Special Issue aims to highlight cutting-edge research and comprehensive reviews that leverage multi-omics strategies to uncover mechanistic insights in agricultural systems. We welcome studies that focus on molecular-level discoveries, including the elucidation of signaling pathways, enzyme function and regulation, metabolite dynamics, and the role of microbiome-derived molecules in host physiology. By integrating multi-omics data, researchers can refine functional gene annotation, decipher epigenetic and post-translational regulatory mechanisms, and link molecular phenotypes to agronomic performance.

We invite submissions that showcase novel multi-omics applications, with a strong emphasis on the identification and functional characterization of key biomolecules. Discovery articles that include validation via experimental data will be considered; articles on tools that rely on simulated data are discouraged. Ultimately, this collection seeks to illustrate how a molecular understanding of biological processes drives the improvement in crop productivity, stress resilience, and the nutritional quality and safety of agricultural products.

Prof. Dr. Rui Li
Prof. Dr. Xinmin Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.