New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 740

Special Issue Editors


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Guest Editor
Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, Section Cerebrovascular Sciences and Neuromodulation, University Hospital Würzburg, 97080 Würzburg, Germany
Interests: cerebrovascular biology; cardiovascular biology; brain-heart; brain cancer; neuroinflammation; ischemic brain injury; systems biology and mathematical modeling
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Guest Editor
School of Systems Biology and the Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA 22030, USA
Interests: multiscale systems biology; computational biology; bioinformatics; cardiac physiology; immunology; mitochondria; cellular signaling; neuroscience; algorithms; HPC
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Interests: cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders.

Cardiovascular disease is the leading cause of death worldwide.  Cardiovascular disease includes heart failure, ischemia, deep vein thrombosis, pulmonary embolism, heart valve disease, pericarditis, rheumatic heart disease, stroke, and other disorders.  Understanding the molecular and physiological mechanisms is necessary for developing effective therapeutics.  This requires both experimental and computational research modalities, spanning scales from the molecular to the organ system level.  Hence, insights can be gained through detailed studies at a particular scale and integrative studies that span multiple scales.  Advances in the treatment of cardiovascular disease require research that spans from basic science to translational research and, ultimately, to clinical studies.  This is reflected in recent advances in molecular biomarkers, which provide both mechanistic insights and clinically actionable treatment strategies.

This Special Issue of Biomolecules will highlight new insights into the mechanisms and therapeutics developed to manage cardiovascular disease. Both new research papers and reviews describing the state of the field and important new directions are welcome.

Prof. Dr. Carola Yvette Förster
Prof. Dr. Mohsin Saleet Jafri
Prof. Dr. Tarun W. Dasari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain–heart axis
  • heart and stroke
  • stress-induced cardiomyopathy
  • cardiovascular disease

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Published Papers (1 paper)

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Review

21 pages, 487 KB  
Review
Role of Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) in Patients with Chronic Heart Failure
by Pasqual Llongueras-Espí, Elena García-Romero, Josep Comín-Colet and José González-Costello
Biomolecules 2025, 15(9), 1342; https://doi.org/10.3390/biom15091342 - 19 Sep 2025
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Abstract
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the management of type 2 diabetes and obesity due to their metabolic benefits. Beyond weight loss and glycemic control, emerging evidence suggests they may also exert cardioprotective effects. In the context of heart failure [...] Read more.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the management of type 2 diabetes and obesity due to their metabolic benefits. Beyond weight loss and glycemic control, emerging evidence suggests they may also exert cardioprotective effects. In the context of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), GLP-1RAs have been associated with improvement in symptoms, physical capacity, biomarkers, and structural cardiac remodeling. These benefits appear to be independent of weight loss, suggesting additional mechanisms including anti-inflammatory effects, improved myocardial metabolism or modulation of epicardial adipose tissue. However, current data largely come from non-HF dedicated trials, with limited standardization of the HF phenotype. Results are overall inconsistent and may suggest potential harm in some cases, particularly in HF with reduced ejection fraction (HFrEF). This review aims to summarize the current evidence on the role of GLP-1RAs in heart failure, explore possible underlying mechanisms and highlight key gaps in knowledge. Full article
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