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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gokmen-Polar

submission deadline 30 Sep 2025 | Viewed by 472 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)

edited by

Galen A. Collins

and Alexander John Dear

submission deadline 30 Sep 2025 | 1 articles | Viewed by 408 | Submission Open

Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by

Dennis R. Grayson

and

Jacob Peedicayil

submission deadline 30 Sep 2025 | Viewed by 175 | Submission Open

Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 30 Sep 2025 | Viewed by 161 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Sep 2025 | Viewed by 127 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 30 Sep 2025 | Viewed by 93 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Sep 2025 | Viewed by 70 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Sep 2025 | Viewed by 65 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

New Insights into Hormonal Control of Plant Growth and Development

edited by

Nihal Dharmasiri

submission deadline 30 Sep 2025 | Viewed by 64 | Submission Open

Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development

(This special issue belongs to the Section Molecular Biology)

Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition

edited by

Simona Clichici

and

Adriana Gabriela Filip

submission deadline 30 Sep 2025 | Viewed by 63 | Submission Open

Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease

edited by

Melina M. Musri

and

Victor I. Peinado

submission deadline 30 Sep 2025 | Viewed by 60 | Submission Open

Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation

(This special issue belongs to the Section Molecular Biology)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 30 Sep 2025 | Viewed by 58 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Sep 2025 | Viewed by 54 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 30 Sep 2025 | Viewed by 52 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Cancer Epigenetics, Post-Translational Modification, and Drug Discovery

edited by

Tao Lu

submission deadline 30 Sep 2025 | Viewed by 51 | Submission Open

Keywords: cancer; drug Discovery; epigenetics; inflammation; NF– κ B

(This special issue belongs to the Section Cellular Biochemistry)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Molecular Mechanisms and Genetics of Human Disease

edited by

Rais Ahmad Ansari

and Ata Abbas

submission deadline 30 Sep 2025 | Viewed by 44 | Submission Open

Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication

Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders

edited by

Wan Lee

submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open

Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies

The Role and Metabolism of Metals in Cancer

edited by

Anna Martina Battaglia

submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open

Keywords: metals; cancer; cancer metabolism

Molecular Mechanisms of Human Skin Aging

edited by

Taihao Quan

submission deadline 15 Oct 2025 | 4 articles | Viewed by 10610 | Submission Open

Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention

(This special issue belongs to the Section Molecular Medicine)

Regulation of Synapses in the Brain

edited by

Kunwei Wu

and Guohao Wang

submission deadline 15 Oct 2025 | Viewed by 63 | Submission Open

Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions

Mechanisms of RNA Regulation in Inflammation

edited by

Roopa Biswas

submission deadline 15 Oct 2025 | Viewed by 29 | Submission Open

Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 16 Oct 2025 | Viewed by 32 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

Molecular Biomarkers of Epileptogenesis

edited by Pedro J. Serrano-Castro

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2694 | Submission Open

Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology

(This special issue belongs to the Section Molecular Biomarkers)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 22 Oct 2025 | Viewed by 22 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

Antituberculous Drugs: Progress and Challenges

edited by

Ana Cristina Faria Ribeiro

and Ana Maria Telmo Dias Pereira Vicente Cabral

submission deadline 25 Oct 2025 | Viewed by 30 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

Molecular and Cellular Mechanisms in Skin Disorders

edited by

Keiichi Yamanaka

submission deadline 30 Oct 2025 | Viewed by 163 | Submission Open

Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Biology)

In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition

edited by

Carmen Cerchia

and

Antonio Lavecchia

submission deadline 31 Oct 2025 | 5 articles | Viewed by 11604 | Submission Open

Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology

edited by

Paolo Fagone

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5373 | Submission Open

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5062 | Submission Open

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

New Insights into the Membranes of Anoxygenic Phototrophic Bacteria

edited by

Robert A. Niederman

submission deadline 31 Oct 2025 | 3 articles | Viewed by 4402 | Submission Open

Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Application of Bioinformatics in Medicine

edited by

Le Zhang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3957 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition

edited by

and

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3762 | Submission Open

Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems

(This special issue belongs to the Section Molecular Medicine)

Molecular and Genetic Basis of Neurodegenerative Diseases

edited by Teresa M. Gunn and Andrea Grindeland

submission deadline 31 Oct 2025 | 5 articles | Viewed by 3544 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation

(This special issue belongs to the Section Molecular Genetics)

Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2876 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Kidney Diseases

edited by

Theodoros Eleftheriadis

and Maria Divani

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1585 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; kidney transplantation; glomerular diseases; ischemia– reperfusion injury; diabetic nephropathy

(This special issue belongs to the Section Molecular Biology)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1473 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Inflammation and Hemostasis: 2nd Edition

edited by

Zsuzsa Bagoly

submission deadline 31 Oct 2025 | 1 articles | Viewed by 972 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Perspectives on Protein and Enzyme Engineering

edited by Haishan Qi and Haoran Yu

submission deadline 31 Oct 2025 | 1 articles | Viewed by 867 | Submission Open

Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Crosstalk Between the Immune and Nervous Systems

edited by

Fuminori Tsuruta

submission deadline 31 Oct 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: microglia; astrocytes; macrophages; cerebral blood vessels; cerebrospinal fluid (CSF); meninges; immune cells; neuroinflammation; neurodegenerative disorders; psychiatric disorders

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular Genetics of Bacteria

edited by Bin Jia

submission deadline 31 Oct 2025 | 1 articles | Viewed by 736 | Submission Open

Keywords: bacterial gene regulation; CRISPR-Cas systems; bacterial resistance; microbial genomics; genome-wide association studies; bacterial pathogenesis; genetic diversity

(This special issue belongs to the Section Molecular Genetics)

Homocysteine and H₂S in Health and Disease, 2nd Edition

edited by

Anton Hermann

and

Guzel F. Sitdikova

submission deadline 31 Oct 2025 | 1 articles | Viewed by 654 | Submission Open

Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation

(This special issue belongs to the Section Chemical Biology)

Involved Biomolecules Within Lysosomal Energy Sensing in Health and Disease

edited by Xianrui Yang and

L. Shannon Holliday

submission deadline 31 Oct 2025 | Viewed by 512 | Submission Open

Keywords: lysosomal energy sensing; vacuolar H+-ATPase (V-ATPase); 5’ -AMP-activated kinase (AMPK); mammalian target of rapamycin (mTor); sirtuin; aldolase; TRPV1; metformin; rapamycin

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 31 Oct 2025 | 1 articles | Viewed by 445 | Submission Open

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 Oct 2025 | 1 articles | Viewed by 373 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 31 Oct 2025 | Viewed by 303 | Submission Open

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Immune Response to Allergens

edited by

Brigita Gradauskiene

submission deadline 31 Oct 2025 | Viewed by 300 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Studies of Protein Dynamics Using Fluorescence Correlation Spectroscopy (FCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 31 Oct 2025 | Viewed by 277 | Submission Open

Keywords: protein dynamics; Fluorescence Correlation Spectroscopy (FCS); protein interactions; subcellular environments; Image Correlation Spectroscopy(ICS) and extensions

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Applications of Biomaterials in Medicine and Healthcare

edited by