Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Focus on Perineural Invasion in Pancreatic Cancer
edited by
submission deadline 25 Sep 2026 | Viewed by 464 | Submission Open
Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins
(This special issue belongs to the Section Molecular Medicine)
Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies submission deadline 25 Sep 2026 | Viewed by 341 | Submission Open
Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis
(This special issue belongs to the Section Biological Factors)
Advances in Plant Genetic Engineering
edited by
submission deadline 25 Sep 2026 | Viewed by 120 | Submission Open
Keywords: plant genetic engineering and biotechnology; CRISPR-Cas system; precise genome editing; synthetic biology; plant transformation and modification; genetically modified plants; plant improvement; biofactories
(This special issue belongs to the Section Molecular Genetics)
Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases
edited by Ann Christin Brorsson
submission deadline 28 Sep 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism
Molecular Advances in Wound Healing and Skin Regeneration
edited by and Muhammad Shafiq
submission deadline 30 Sep 2026 | 3 articles | Viewed by 39735 | Submission Open
Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair
(This special issue belongs to the Section Biological Factors)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 13009 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 30 Sep 2026 | 4 articles | Viewed by 7968 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in Section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates"
edited by
submission deadline 30 Sep 2026 | 6 articles | Viewed by 5685 | Submission Open
Keywords: biomacromolecules; proteins; DNA; RNA; chromatin; epigenetics; gene regulation; genomics; proteomics; metabolomics; computational approaches; molecular biotechnology; molecular therapeutics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Natural Products and Their Derivatives with Antiviral Activity
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 5479 | Submission Open
Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2026 | 2 articles | Viewed by 3117 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Advances in the Pathology of Prostate Cancer: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2879 | Submission Open
Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy
(This special issue belongs to the Section Chemical Biology)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 30 Sep 2026 | 1 articles | Viewed by 2527 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2450 | Submission Open
Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders
(This special issue belongs to the Section Molecular Medicine)
Deciphering Disease Progression Through Multi-Omics Integration
edited by Cinzia Franchin
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2438 | Submission Open
Keywords: multi-omics integration; systems biology; biomarkers; disease progression; precision medicine; computational modelling
(This special issue belongs to the Section Molecular Biology)
Advanced Therapeutic Strategies for Hormone-Dependent Cancers submission deadline 30 Sep 2026 | 1 articles | Viewed by 2373 | Submission Open
Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers
(This special issue belongs to the Section Molecular Medicine)
Fibrinogen and Fibrin in Human Diseases
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2045 | Submission Open
Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis
(This special issue belongs to the Section Molecular Biology)
The Role of Heparin in Blood
edited by , and Denisa Cont
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2018 | Submission Open
Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)
(This special issue belongs to the Section Molecular Medicine)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1887 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Mechanisms Underlying Liver Diseases: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1871 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
Feature Papers in Section “Cellular Biochemistry”, 2nd Edition submission deadline 30 Sep 2026 | 2 articles | Viewed by 1816 | Submission Open
Keywords: cell signalling; cell death; intracellular trafficking (protein; lipids; cytoskeleton; etc.); host– pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity
(This special issue belongs to the Section Cellular Biochemistry)
From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1312 | Submission Open
Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Regulation of Transcription Factors in Plant Growth and Stress Responses
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1088 | Submission Open
Keywords: transcription factors; plant growth and development; abiotic and biotic stress; gene regulatory networks; molecular regulation
(This special issue belongs to the Section Molecular Biology)
Mechanisms in Stress-Related Disorders, Anxiety and Fear
edited by Veronica Begni
submission deadline 30 Sep 2026 | 1 articles | Viewed by 884 | Submission Open
Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
Cancer Research: Molecular Insights and Therapeutic Strategies submission deadline 30 Sep 2026 | 1 articles | Viewed by 694 | Submission Open
Keywords: cancer biology; molecular mechanisms; oncogenic signaling pathways; molecular targets; targeted therapy
(This special issue belongs to the Section Molecular Medicine)
Mitochondrial ROS in Health and Disease: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 543 | Submission Open
Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel
(This special issue belongs to the Section Chemical Biology)
Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health submission deadline 30 Sep 2026 | Viewed by 498 | Submission Open
Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems
New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles
edited by , Serdar Dursun and
submission deadline 30 Sep 2026 | Viewed by 386 | Submission Open
Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD
Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement submission deadline 30 Sep 2026 | Viewed by 363 | Submission Open
Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance
Spatial and Single-Cell Phosphoproteomics: Emerging Methods and Applications
edited by Cinzia Franchin
submission deadline 30 Sep 2026 | Viewed by 336 | Submission Open
Keywords: phosphoproteomics; single-cell phosphoproteomics; cell signalling; spatial phosphoproteomics; phosphopeptides
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Current Treatment Strategy of Sarcomas submission deadline 30 Sep 2026 | Viewed by 332 | Submission Open
Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target
(This special issue belongs to the Section Molecular Medicine)
Role of Lipids in Cellular Metabolism and Communication
edited by
submission deadline 30 Sep 2026 | Viewed by 301 | Submission Open
Keywords: sphingolipids; phospholipids; eicosanoids; steroids; extracellular vesicles; cancer; diabetes; obesity; atherosclerosis
(This special issue belongs to the Section Lipids)
Molecular Circuits of Cell Fate Reprogramming and Plasticity
edited by
submission deadline 30 Sep 2026 | Viewed by 271 | Submission Open
Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional; post-transcriptional; and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Targeted At-211 Alpha Therapy
edited by Hsiaoju Sharon Lee and Yawen Li
submission deadline 30 Sep 2026 | Viewed by 263 | Submission Open
Keywords: Astatine-211; astatination; targeted alpha therapy; alpha radioimmunotherapy; radiotheranostics; radiopharmaceuticals
(This special issue belongs to the Section Chemical Biology)
Choline and Its Supplementation in Human Health and Disease
edited by and Enea Traini
submission deadline 30 Sep 2026 | Viewed by 245 | Submission Open
Keywords: choline; transporters; deficiencies; supplementations
(This special issue belongs to the Section Molecular Medicine)
Biomolecules and Material-Based Approaches in Biomedical Field—3rd Edition submission deadline 30 Sep 2026 | Viewed by 241 | Submission Open
Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Novel Targets in Peripheral Neurotoxicity
edited by , and Federico Iseppon
submission deadline 30 Sep 2026 | Viewed by 233 | Submission Open
Keywords: peripheral neuropathies; peripheral neurotoxicity; ion channels; axonal damage; chemotherapy-induced peripheral neurotoxicity; pain; neuropathic pain
(This special issue belongs to the Section Molecular Biology)
Interleukin-11 Signalling in Cross-Tissue Diseases: Mechanisms, Pathophysiological Roles, and Therapeutic Targeting
edited by and Mark Sweeney
submission deadline 30 Sep 2026 | Viewed by 195 | Submission Open
Keywords: Interleukin-11; pathology; fibrosis; inflammation; therapeutics
(This special issue belongs to the Section Molecular Biomarkers)
Decoding Cellular Pathogenesis of Hypertension: Emerging Mechanisms and Therapeutic Targets
edited by Satoru Eguchi and Yuka Terada
submission deadline 30 Sep 2026 | Viewed by 187 | Submission Open
Keywords: omics; microbiota; signal transduction; epigenetics; cellular mechanisms
(This special issue belongs to the Section Molecular Medicine)
Microbial Metabolites as Key Mediators of Host Health submission deadline 30 Sep 2026 | Viewed by 180 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins; secondary bile acids
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging: 2nd Edition
edited by Mark McCormick
submission deadline 30 Sep 2026 | Viewed by 168 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Biological Factors)
The Impact of Blood Pressure on Neurological Outcomes
edited by Phillip J. Tully
submission deadline 30 Sep 2026 | Viewed by 163 | Submission Open
Keywords: neurological disorders; neurodegenerative disorders; brain imaging; dementia; hypertension; blood pressure; cerebral blood flow
(This special issue belongs to the Section Molecular Medicine)
Non-Natural Nucleotides: From Chemistry to Biochemistry to Cancer Pharmacology
edited by
submission deadline 30 Sep 2026 | Viewed by 159 | Submission Open
Keywords: nucleoside analogs; nucleic acid metabolism; DNA replication; mRNA vaccines; energy transfer; cell signaling; therapeutic agents
(This special issue belongs to the Section Chemical Biology)
Melatonin in Normal Physiology and Disease, 3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 159 | Submission Open
Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Functional Roles of Integral Membrane Proteins in Health and Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 116 | Submission Open
Keywords: membrane proteins; molecular mechanisms; structural biology; post-translational modifications; protein interactions; biophysics
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Peroxisomes at the Crossroads of Cell Biology, Physiology, and Disease
edited by , Xin (Daniel) Gao and Maximiliano Presa
submission deadline 30 Sep 2026 | Viewed by 113 | Submission Open
Keywords: peroxisomes; basic research; mechanisms of disease; animal models; gene therapy; targeted therapies; clinical biomarkers
(This special issue belongs to the Section Enzymology)
DNA Damage Response and Repair in Ovarian Cancer submission deadline 30 Sep 2026 | Viewed by 112 | Submission Open
Keywords: DNA damage response; DNA repair; ovarian cancer; PARP inhibitors
(This special issue belongs to the Section Cellular Biochemistry)
The Regulatory Mechanisms of Natural Bioactive Molecules on Metabolism and Immunity
edited by
submission deadline 10 Oct 2026 | 1 articles | Viewed by 1322 | Submission Open
Keywords: natural bioactive molecules; metabolic regulation; immune modulation; inflammation and immunity; immunometabolism
(This special issue belongs to the Section Biological Factors)
Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics
edited by
submission deadline 15 Oct 2026 | 1 articles | Viewed by 1430 | Submission Open
Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics  
(This special issue belongs to the Section Cellular Biochemistry)
Advanced Analytical Techniques in Forensic and Clinical Biomarker Discovery submission deadline 15 Oct 2026 | Viewed by 182 | Submission Open
Keywords: post-mortem toxicology; clinical chemistry; forensic biomarkers; metabolomics; advanced detection techniques
(This special issue belongs to the Section Molecular Biomarkers)
Extracellular Vesicles as Signaling Hubs: From Lipid Biomarkers to Cellular Communication
edited by
submission deadline 15 Oct 2026 | Viewed by 176 | Submission Open
Keywords: extracellular vesicles; bioactive lipids; cellular communication; lipid rafts; signal transduction; pathophysiology
(This special issue belongs to the Section Cellular Biochemistry)
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