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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Basis of Pathogenesis in Autoimmune Diseases

edited by

I-Tsu Chyuan

and

Chi-Jung Huang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1704 | Submission Open

Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets

(This special issue belongs to the Section Molecular Medicine)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1512 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications

edited by Yalin Qi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1453 | Submission Open

Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection

(This special issue belongs to the Section Chemical Biology)

Vertebrate Comparative Genomics

edited by Ya-Xiong Tao and

Shan He

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1150 | Submission Open

Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene

(This special issue belongs to the Section Molecular Genetics)

Molecular Basis and Oxidative Stress of Thyroid Diseases

edited by

Małgorzata Karbownik-Lewińska

and

Jan Stȩpniak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1032 | Submission Open

Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease

(This special issue belongs to the Section Biological Factors)

Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism

edited by

Katsuhiko Suzuki

and

Kayvan Khoramipour

submission deadline 31 Dec 2025 | 1 articles | Viewed by 997 | Submission Open

Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Chromatin and Chromosome Molecular Research

edited by Xin Bi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 961 | Submission Open

Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 Dec 2025 | 2 articles | Viewed by 877 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

Mechanosensitivity and Ion Channels

edited by Olivia García-Suarez and Yolanda García-Mesa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Ion Channels in Cardiovascular and Metabolic Diseases

edited by

Shang-Zhong Xu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 668 | Submission Open

Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters

(This special issue belongs to the Section Biological Factors)

Phytohormones 2024–2025

edited by Guzel Kudoyarova

submission deadline 31 Dec 2025 | Viewed by 655 | Submission Open

Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates

(This special issue belongs to the Section Natural and Bio-derived Molecules)

State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia

edited by

Xuanyu Meng

and

Ruhong Zhou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 620 | Submission Open

Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning

(This special issue belongs to the Section Chemical Biology)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Dec 2025 | 1 articles | Viewed by 559 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

edited by

Monika Pitucha

and

Marta Rusek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 392 | Submission Open

Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry

(This special issue belongs to the Section Chemical Biology)

Biomolecules in Myocarditis and Inflammatory Heart Disease

edited by

Amarylis Claudine Bonito A. Wanschel

submission deadline 31 Dec 2025 | 1 articles | Viewed by 354 | Submission Open

Keywords: cardiomyocyte; macrophage; cardiac remodeling; oxidative and nitrosative stress; neutrophils

(This special issue belongs to the Section Molecular Medicine)

The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication

edited by

Yuqian Yan

submission deadline 31 Dec 2025 | Viewed by 322 | Submission Open

Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis

(This special issue belongs to the Section Cellular Biochemistry)

Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches

edited by

Milica Perišić Nanut

submission deadline 31 Dec 2025 | Viewed by 315 | Submission Open

Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors

(This special issue belongs to the Section Molecular Biology)

Immunofluorescent Techniques in Animal Stem Cell Research

edited by

Jaromír Vašíček

and Andrea Svoradová

submission deadline 31 Dec 2025 | Viewed by 301 | Submission Open

Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Organometallic Syntheses for Biomedical Applications

edited by Bala Krishna Moku

submission deadline 31 Dec 2025 | Viewed by 275 | Submission Open

Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Advances in Computational Biology of Intrinsically Disordered Proteins

edited by

Paul Harrison

submission deadline 31 Dec 2025 | Viewed by 263 | Submission Open

Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

The Role of Calcium Signaling in Cardiac and Skeletal Muscle

edited by

Andreas Rinne

and

Florentina Pluteanu

submission deadline 31 Dec 2025 | Viewed by 245 | Submission Open

Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation

(This special issue belongs to the Section Molecular Biology)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Dec 2025 | Viewed by 237 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying Liver Diseases: 2nd Edition

edited by

Wei Zhong

submission deadline 31 Dec 2025 | Viewed by 226 | Submission Open

Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights

(This special issue belongs to the Section Cellular Biochemistry)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation

edited by

Tamara Hendrickson

submission deadline 31 Dec 2025 | Viewed by 210 | Submission Open

Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification

(This special issue belongs to the Section Molecular Genetics)

Molecular and Cellular Mechanisms of Aortic Aneurysms

edited by Maria Giovanna Scioli

submission deadline 31 Dec 2025 | Viewed by 203 | Submission Open

Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Sjogren’s Syndrome: Recent Updates and Perspectives

edited by

Carlo Perricone

submission deadline 31 Dec 2025 | Viewed by 184 | Submission Open

Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines

Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition

edited by

Grzegorz Janusz

and

Anna Pawlik

submission deadline 31 Dec 2025 | 1 articles | Viewed by 149 | Submission Open

Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering

(This special issue belongs to the Section Enzymology)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress

edited by

Hakim Manghwar

submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open

Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Neurological and Psychological Disorders

edited by

Xiang-Ping Chu

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target

(This special issue belongs to the Section Molecular Biology)

The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

edited by

Maria Beatrice Morelli

submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open

Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions

edited by Yurong Xie and Hongbin Wei

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding

(This special issue belongs to the Section Molecular Genetics)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Lung Cancer: From Molecular Basis to Therapy

edited by

Paolo Borghetti

submission deadline 31 Dec 2025 | Viewed by 119 | Submission Open

Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic

(This special issue belongs to the Section Molecular Biology)

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition

edited by

Eun-Woo Lee

and Jiho Yoo

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology

(This special issue belongs to the Section Cellular Biochemistry)

p53 Family: The Molecular Landscape in Cancer and Beyond

edited by

Paola Tucci

and Michele Pellegrino

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition

edited by

Juei-Tang Cheng

submission deadline 31 Dec 2025 | Viewed by 104 | Submission Open

Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health

Antituberculous Drugs: Progress and Challenges

edited by

Ana Cristina Faria Ribeiro

and Ana Maria Telmo Dias Pereira Vicente Cabral

submission deadline 31 Dec 2025 | Viewed by 96 | Submission Open

Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems

(This special issue belongs to the Section Chemical Biology)

Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction

edited by

, Qiuhua Yang,

and

submission deadline 31 Dec 2025 | Viewed by 90 | Submission Open

Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE

(This special issue belongs to the Section Molecular Medicine)

Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases

edited by

Balraj Gopula

Tamal Kanti Das

and Arun Raja

submission deadline 31 Dec 2025 | Viewed by 87 | Submission Open

Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology

(This special issue belongs to the Section Chemical Biology)

The Role of DNA Methylation, Histone Modifications and MicroRNA in Cancer

edited by

Joanna Szczepanek

submission deadline 31 Dec 2025 | Viewed by 83 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; microRNA; cancer progression; therapeutic resistance; tumor suppressor genes; oncogenic reprogramming; personalized cancer therapy; epigenetic therapy

(This special issue belongs to the Section Molecular Genetics)

Biomaterial Innovations for Tissue Engineering and Regeneration

edited by

Maria Chatzinikolaidou

submission deadline 31 Dec 2025 | Viewed by 81 | Submission Open

Keywords: biomaterials; tissue engineering; regenerative medicine; cellular responses; 3D pathophysiological tissue models

(This special issue belongs to the Section Bio-Engineered Materials)

Proteogenomics in Cancer Research

edited by

Chen Huang

submission deadline 31 Dec 2025 | Viewed by 78 | Submission Open

Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 31 Dec 2025 | Viewed by 72 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 31 Dec 2025 | Viewed by 46 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

(This special issue belongs to the Section Cellular Biochemistry)

Nutritional Intervention and Molecular Mechanism of Liver Cancer

edited by