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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition

edited by

Paolo Fagone

submission deadline 20 Jun 2026 | Viewed by 263 | Submission Open

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

Oral Cancer: New Advances in Therapies

edited by

Daniela Adamo

Gennaro Musella

and Nicola Cirillo

submission deadline 20 Jun 2026 | Viewed by 228 | Submission Open

Keywords: oral cancer; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; radiotherapy; chemotherapy; gene therapy; precision medicine; translational research

(This special issue belongs to the Section Molecular Medicine)

South American Native Species as Sources of Bioactive Compounds: Opportunities and Challenges

edited by Andressa Mara Baseggio and Maurício Ariel Rostagno

submission deadline 20 Jun 2026 | Viewed by 205 | Submission Open

Keywords: South American biodiversity; bioactive compounds; chemical characterization; health properties

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Novel Signaling Pathways in Cardiometabolic Diseases

edited by

Wei Liu

submission deadline 20 Jun 2026 | Viewed by 191 | Submission Open

Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation

(This special issue belongs to the Section Biological Factors)

WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications

edited by Wenhai Shao

submission deadline 20 Jun 2026 | Viewed by 177 | Submission Open

Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus

(This special issue belongs to the Section Molecular Medicine)

The Role of Nanoparticles in Tumor Treatment

edited by

Carla Vitorino

submission deadline 25 Jun 2026 | 3 articles | Viewed by 14209 | Submission Open

Keywords: nanoparticles; cancer therapy; nanotechnology

(This special issue belongs to the Section Chemical Biology)

Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets

edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev

submission deadline 25 Jun 2026 | Viewed by 231 | Submission Open

Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Medicine)

Intercellular Communication in Differentiation

edited by

Alvin Liu

submission deadline 25 Jun 2026 | Viewed by 161 | Submission Open

Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules

Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress

edited by

Hakim Manghwar

submission deadline 26 Jun 2026 | 6 articles | Viewed by 5063 | Submission Open

Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions

edited by Yurong Xie and Hongbin Wei

submission deadline 26 Jun 2026 | 2 articles | Viewed by 1871 | Submission Open

Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding

(This special issue belongs to the Section Molecular Genetics)

Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases

edited by

Balraj Gopula

Tamal Kanti Das

and Arun Raja

submission deadline 26 Jun 2026 | 1 articles | Viewed by 1017 | Submission Open

Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology

(This special issue belongs to the Section Chemical Biology)

Spotlight on Hot Cancer Biological Biomarkers

edited by

Dania Cioni

and

Salvatore Claudio Fanni

submission deadline 30 Jun 2026 | 4 articles | Viewed by 13051 | Submission Open

Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology

(This special issue belongs to the Section Molecular Biomarkers)

Mechanisms of Kidney Injury and Treatment Modalities

edited by Utpal Sen

submission deadline 30 Jun 2026 | 3 articles | Viewed by 11282 | Submission Open

Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration

(This special issue belongs to the Section Molecular Biology)

Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou

edited by

Christina Piperi

and

George D. Kalliolias

submission deadline 30 Jun 2026 | 4 articles | Viewed by 11071 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease

edited by

Toshimitsu Yamaoka

submission deadline 30 Jun 2026 | 6 articles | Viewed by 9456 | Submission Open

Keywords: pulmonary diseases; diagnostics; therapeutics

(This special issue belongs to the Section Molecular Medicine)

Polyphosphate (PolyP) in Health and Disease

edited by

Félix A. Ruiz

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6059 | Submission Open

Keywords: polyphosphate; polyP; biomarker and therapeutic target

(This special issue belongs to the Section Natural and Bio-derived Molecules)

New Insights into Protein Aggregation in Condensed and Amyloid States

edited by

Eva Žerovnik

and

Veronika Stoka

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5915 | Submission Open

Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5830 | Submission Open

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition

edited by

Simona Clichici

and

Adriana Gabriela Filip

submission deadline 30 Jun 2026 | 5 articles | Viewed by 5220 | Submission Open

Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications

edited by

Agata Pomorska

Aneta Michna

and

Maria Morga

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4769 | Submission Open

Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

New Insights into Stem Cell-Derived Exosomes in Human Health and Disease

edited by

Lubos Danisovic

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3991 | Submission Open

Keywords: stem cells; exosomes; regenerative medicine; diagnostics

(This special issue belongs to the Section Cellular Biochemistry)

Lipid Signaling in Human Disease

edited by

Berit Johansen

and Felicity Ashcroft

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3650 | Submission Open

Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids

(This special issue belongs to the Section Lipids)

Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases

edited by Aurora Daniele and

Ersilia Nigro

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3646 | Submission Open

Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease

(This special issue belongs to the Section Biological Factors)

Mitochondria as a Target for Tissue Repair and Regeneration

edited by

Igor A. Prudovsky

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3582 | Submission Open

Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy

(This special issue belongs to the Section Molecular Biology)

Molecular Basis and Novel Treatment of Epilepsy

edited by

Fang Zheng

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3445 | Submission Open

Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research

(This special issue belongs to the Section Molecular Biology)

Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application

edited by

Nebojsa Nick Knezevic

and

Aleksandar Sič

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3115 | Submission Open

Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders

(This special issue belongs to the Section Biological Factors)

Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications

edited by

Marina Piscopo

and

Carmen Di Giovanni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2548 | Submission Open

Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine

(This special issue belongs to the Section Cellular Biochemistry)

Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals

edited by

Monika Pitucha

and

Marta Rusek

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2378 | Submission Open

Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry

(This special issue belongs to the Section Chemical Biology)

Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies

edited by

Anat Galor

and Pragnya Rao Donthineni

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2347 | Submission Open

Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis

(This special issue belongs to the Section Cellular Biochemistry)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2305 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2160 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Exercise Immunology: Molecular Mechanisms and Health Applications

edited by

Dorota Kostrzewa-Nowak

Robert Nowak

, Michał Sławiński and

Patrizia Proia

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2142 | Submission Open

Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors

(This special issue belongs to the Section Molecular Biology)

Immune Response to Allergens

edited by

Brigita Gradauskiene

and

Sandra Sakalauskaite

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1906 | Submission Open

Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy

(This special issue belongs to the Section Cellular Biochemistry)

Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System

edited by

Dimitrios Kouroupis

and

Enrico Ragni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1465 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles ; musculoskeletal regeneration ; immunomodulation ; anabolism ; cell therapy ; cell-free therapy ; secretome

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1238 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Exploring Physical Mechanisms in Inflammation Regulation

edited by

Christine Nardini

and

Vitalii Zablotskii

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1166 | Submission Open

Keywords: physical stimuli; transduction; magnetic field; electric field; magnetotherapy; laser therapy

(This special issue belongs to the Section Biological Factors)

Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials

edited by Caterina Ricci and

Maria Grazia Ortore

submission deadline 30 Jun 2026 | Viewed by 362 | Submission Open

Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization

Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders

edited by

Wan Lee

submission deadline 30 Jun 2026 | Viewed by 360 | Submission Open

Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies

Bacterial Molecular Biology: Stress Responses and Adaptation

edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa

submission deadline 30 Jun 2026 | Viewed by 325 | Submission Open

Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks

(This special issue belongs to the Section Molecular Biology)

Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation

edited by Konstantinos Venetis,

Nicola Fusco

and Marianna D'Ercole

submission deadline 30 Jun 2026 | Viewed by 304 | Submission Open

Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology

(This special issue belongs to the Section Molecular Biomarkers)

Second Messenger Systems in Cellular Communication and Disease

edited by

Vijay Parashar

submission deadline 30 Jun 2026 | Viewed by 296 | Submission Open

Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition

edited by

Adriana Georgescu

submission deadline 30 Jun 2026 | Viewed by 284 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease

Molecular and Physiological Regulation of Biomechanical Signalling

edited by

Lars Kaestner

submission deadline 30 Jun 2026 | Viewed by 278 | Submission Open

Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics

Plant Secondary Metabolism Engineering and Bioactive Compounds

edited by

Barbara Tokarz

and

Wojciech Makowski

submission deadline 30 Jun 2026 | Viewed by 271 | Submission Open

Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Advances in Protein–Ligand Interactions: From Structure, Function to Applications, 2nd Edition

edited by

Mateusz Banach

submission deadline 30 Jun 2026 | Viewed by 267 | Submission Open

Keywords: bioinformatics; compound libraries; computational biology; de novo drug design; drug discovery; ligand binding; machine learning; molecular docking; molecular dynamics; protein complexes

(This special issue belongs to the Section Chemical Biology)

Non-Invasive Biomarker Screening in Cancer

edited by

Iqbal Mahmud

and F. G. Pinto

submission deadline 30 Jun 2026 | Viewed by 264 | Submission Open

Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies

(This special issue belongs to the Section Molecular Biomarkers)

Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights

edited by Anna Barbara Di Stefano

submission deadline 30 Jun 2026 | Viewed by 242 | Submission Open

Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies

(This special issue belongs to the Section Cellular Biochemistry)

Enolase: Molecular Functions and Pathological Roles in Health and Disease

edited by

Anja Pišlar

submission deadline 30 Jun 2026 | Viewed by 228 | Submission Open

Keywords: enolase; enzyme regulation; cancer metabolism; neurodegeneration; autoimmune disease; biomarkers; inflammation; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Interactions and Microbial Biocontrol Strategies in Host-Parasite-Pest Systems

edited by Rubén Marino Cardozo

submission deadline 30 Jun 2026 | Viewed by 202 | Submission Open

Keywords: molecular interactions; bioactive molecules; pest– microbe– host systems; microbial biocontrol; eco-evolutionary mechanisms; molecular parasitology; host– parasite interactions

(This special issue belongs to the Section Cellular Biochemistry)

Nanomaterials and Their Applications in Biomedicine—2nd Edition

edited by

George Pasparakis

submission deadline 30 Jun 2026 | Viewed by 200 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors; including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery; including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

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