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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Sep 2025 | 3 articles | Viewed by 5203 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities

edited by

Antonio Garrido

submission deadline 30 Sep 2025 | 1 articles | Viewed by 4290 | Submission Open

Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition

(This special issue belongs to the Section Biological Factors)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 30 Sep 2025 | 1 articles | Viewed by 3894 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 30 Sep 2025 | 4 articles | Viewed by 3584 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Lipids Metabolism in Cardiovascular Disease

edited by Anand K. Rohatgi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 3321 | Submission Open

Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis

(This special issue belongs to the Section Molecular Medicine)

New Insights into Protein Aggregation in Condensed and Amyloid States

edited by

Eva Žerovnik

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2631 | Submission Open

Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges

edited by

Valeria Gasperi

Maria Valeria Catani

and

Alessandra Gambacurta

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2610 | Submission Open

Keywords: biomarker; molecular biology; bioinformatics

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Stem Cells in Musculoskeletal Tissue Engineering

edited by

Chenshuang Li

and

Zhong Zheng

submission deadline 30 Sep 2025 | 2 articles | Viewed by 2232 | Submission Open

Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs

(This special issue belongs to the Section Bio-Engineered Materials)

Cancer Epigenetics, Post-Translational Modification, and Drug Discovery

edited by

Tao Lu

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1994 | Submission Open

Keywords: cancer; drug Discovery; epigenetics; inflammation; NF– κ B

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Therapeutic Targets in Leukaemia

edited by

Sabrina Tosi

and

Denise Ragusa

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1792 | Submission Open

Keywords: leukaemia; blood; genetics; genomics; chromosome

(This special issue belongs to the Section Molecular Medicine)

Role of Postbiotics on Health Maintenance and Recovery

edited by

Luigi Santacroce

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1605 | Submission Open

Keywords: human microbiota; postbiotics; lantibiotics; SCFAs; SCFAs receptors; immune regulation; synbiotics; psychobiotics; dysbiosis; TMAO

(This special issue belongs to the Section Molecular Biology)

Mechanisms, Biology and Regulation of Proteasomes—in Memory of Professor Alfred L. Goldberg (1942–2023)

edited by

Galen A. Collins

and Alexander John Dear

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1421 | Submission Open

Keywords: proteasomes; ubiquitin; protease mechanisms; protease inhibitors; ATPases; muscle atrophy; antigen presentation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1346 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1088 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Genetics of Human Disease

edited by

Rais Ahmad Ansari

and Ata Abbas

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1039 | Submission Open

Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication

(This special issue belongs to the Section Molecular Genetics)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1012 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

T Cell Ca²⁺ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies

edited by David W. Thomas and

Marc André Lécuyer

submission deadline 30 Sep 2025 | 1 articles | Viewed by 760 | Submission Open

Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals

(This special issue belongs to the Section Cellular Biochemistry)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by

Dennis R. Grayson

and

Jacob Peedicayil

submission deadline 30 Sep 2025 | 1 articles | Viewed by 704 | Submission Open

Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gokmen-Polar

submission deadline 30 Sep 2025 | Viewed by 543 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition

edited by

Simona Clichici

and

Adriana Gabriela Filip

submission deadline 30 Sep 2025 | 1 articles | Viewed by 450 | Submission Open

Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine

(This special issue belongs to the Section Bio-Engineered Materials)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 30 Sep 2025 | Viewed by 203 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Sep 2025 | Viewed by 186 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Sep 2025 | Viewed by 158 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

New Insights into Hormonal Control of Plant Growth and Development

edited by

Nihal Dharmasiri

submission deadline 30 Sep 2025 | Viewed by 156 | Submission Open

Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development

(This special issue belongs to the Section Molecular Biology)

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 30 Sep 2025 | Viewed by 135 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Sep 2025 | Viewed by 118 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

The Role and Metabolism of Metals in Cancer

edited by

Anna Martina Battaglia

submission deadline 30 Sep 2025 | Viewed by 108 | Submission Open

Keywords: metals; cancer; cancer metabolism

(This special issue belongs to the Section Chemical Biology)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Sep 2025 | Viewed by 99 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders

edited by

Wan Lee

submission deadline 30 Sep 2025 | Viewed by 83 | Submission Open

Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies

Molecular Mechanisms of Human Skin Aging

edited by

Taihao Quan

submission deadline 15 Oct 2025 | 4 articles | Viewed by 14055 | Submission Open

Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention

(This special issue belongs to the Section Molecular Medicine)

Regulation of Synapses in the Brain

edited by

Kunwei Wu

and Guohao Wang

submission deadline 15 Oct 2025 | Viewed by 156 | Submission Open

Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Mechanisms of RNA Regulation in Inflammation

edited by

Roopa Biswas

submission deadline 15 Oct 2025 | Viewed by 82 | Submission Open

Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 16 Oct 2025 | Viewed by 103 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Molecular Biomarkers of Epileptogenesis

edited by Pedro J. Serrano-Castro

submission deadline 20 Oct 2025 | 3 articles | Viewed by 6949 | Submission Open

Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology

(This special issue belongs to the Section Molecular Biomarkers)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 22 Oct 2025 | Viewed by 91 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications

edited by George Kokotos and

Christiana Mantzourani

submission deadline 25 Oct 2025 | Viewed by 58 | Submission Open

Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms in Skin Disorders

edited by

Keiichi Yamanaka

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1919 | Submission Open

Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Biology)

In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition

edited by

Carmen Cerchia

and

Antonio Lavecchia

submission deadline 31 Oct 2025 | 6 articles | Viewed by 14540 | Submission Open

Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology

edited by

Paolo Fagone

submission deadline 31 Oct 2025 | 8 articles | Viewed by 13562 | Submission Open

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Oct 2025 | 6 articles | Viewed by 10983 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 Oct 2025 | 4 articles | Viewed by 9467 | Submission Open

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition

edited by

and

submission deadline 31 Oct 2025 | 7 articles | Viewed by 8892 | Submission Open

Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems

(This special issue belongs to the Section Molecular Medicine)

Advances in Cellular Biophysics: Transport and Mechanics

edited by Boris Musset and

Peter Pohl

submission deadline 31 Oct 2025 | 5 articles | Viewed by 7836 | Submission Open

Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Drosophila as a Model System to Study Metabolism

edited by

Justin R. DiAngelo

submission deadline 31 Oct 2025 | 5 articles | Viewed by 7681 | Submission Open

Keywords: carbohydrate; lipid; amino acid; Drosophila; metabolism; insulin; TOR; autophagy; fasting

(This special issue belongs to the Section Molecular Biology)

Molecular and Genetic Basis of Neurodegenerative Diseases

edited by Teresa M. Gunn and Andrea Grindeland

submission deadline 31 Oct 2025 | 6 articles | Viewed by 6989 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation

(This special issue belongs to the Section Molecular Genetics)

Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 Oct 2025 | 3 articles | Viewed by 6708 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Application of Bioinformatics in Medicine

edited by

Le Zhang

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5669 | Submission Open

Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology

(This special issue belongs to the Section Bioinformatics and Systems Biology)

New Insights into the Membranes of Anoxygenic Phototrophic Bacteria

edited by

Robert A. Niederman

submission deadline 31 Oct 2025 | 3 articles | Viewed by 5130 | Submission Open

Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 Oct 2025 | 2 articles | Viewed by 4644 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

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