Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Structures in RNA Viruses
edited by Riccardo Delli Ponti, , and Laura Broglia
submission deadline 15 Jun 2026 | Viewed by 275 | Submission Open
Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs
edited by
submission deadline 19 Jun 2026 | 2 articles | Viewed by 3170 | Submission Open
Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs
Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming
edited by
submission deadline 19 Jun 2026 | Viewed by 264 | Submission Open
Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Biomarkers of Epileptogenesis submission deadline 20 Jun 2026 | 6 articles | Viewed by 19144 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
Advances in p53 Research submission deadline 20 Jun 2026 | 3 articles | Viewed by 18093 | Submission Open
Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)
(This special issue belongs to the Section Molecular Biology)
Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition
edited by and Naoko Tsugawa
submission deadline 20 Jun 2026 | 3 articles | Viewed by 3424 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450
(This special issue belongs to the Section Chemical Biology)
Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 1874 | Submission Open
Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 258 | Submission Open
Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy
(This special issue belongs to the Section Cellular Biochemistry)
Oral Cancer: New Advances in Therapies
edited by , and Nicola Cirillo
submission deadline 20 Jun 2026 | Viewed by 224 | Submission Open
Keywords: oral cancer; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; radiotherapy; chemotherapy; gene therapy; precision medicine; translational research
(This special issue belongs to the Section Molecular Medicine)
South American Native Species as Sources of Bioactive Compounds: Opportunities and Challenges
edited by Andressa Mara Baseggio and Maurício Ariel Rostagno
submission deadline 20 Jun 2026 | Viewed by 201 | Submission Open
Keywords: South American biodiversity; bioactive compounds; chemical characterization; health properties
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Novel Signaling Pathways in Cardiometabolic Diseases
edited by
submission deadline 20 Jun 2026 | Viewed by 189 | Submission Open
Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation
(This special issue belongs to the Section Biological Factors)
WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications
edited by Wenhai Shao
submission deadline 20 Jun 2026 | Viewed by 170 | Submission Open
Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus
(This special issue belongs to the Section Molecular Medicine)
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 25 Jun 2026 | 3 articles | Viewed by 14108 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
(This special issue belongs to the Section Chemical Biology)
Pulmonary Fibrosis: From Molecular Mechanism to Therapeutic Targets
edited by Santosh Yadav, Muralidharan Anbalagan and Renat Shaykhiev
submission deadline 25 Jun 2026 | Viewed by 228 | Submission Open
Keywords: idiopathic pulmonary fibrosis; DNA damage response; senescence; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Medicine)
Intercellular Communication in Differentiation
edited by
submission deadline 25 Jun 2026 | Viewed by 154 | Submission Open
Keywords: intercellular communication; cellular differentiation; transcription factors; signaling hormone molecules
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 26 Jun 2026 | 6 articles | Viewed by 4966 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 26 Jun 2026 | 2 articles | Viewed by 1842 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1001 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Spotlight on Hot Cancer Biological Biomarkers submission deadline 30 Jun 2026 | 4 articles | Viewed by 12952 | Submission Open
Keywords: cancer biomarkers; precision medicine; liquid biopsy; imaging biomarkers; translational oncology
(This special issue belongs to the Section Molecular Biomarkers)
Mechanisms of Kidney Injury and Treatment Modalities
edited by Utpal Sen
submission deadline 30 Jun 2026 | 3 articles | Viewed by 11160 | Submission Open
Keywords: acute and chronic kidney injury; autophagy and mitophagy; bioenergetics; mitochondrial damage; and biogenesis; current therapeutic modalities and future strategies; epigenetic DNA methylation; histone modification; and non-coding RNAs and miRNAs; gaseous molecules and signaling pathways; gender differences; aging; and kidney dysfunction; glomerulosclerosis and renovascular remodelling following injury; gut– kidney axis and health; hypertensive; diabetic; and IgA nephropathy; inflammatory vs. reparatory macrophages and renal repair; ischemia and reperfusion injury; matrix protein; metalloproteinases; and their inhibitors; necrosis; necroptosis; apoptosis; pyroptosis; and ferroptosis; renal repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou submission deadline 30 Jun 2026 | 4 articles | Viewed by 10992 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathology, Diagnostics, and Therapeutics of Lung Disease
edited by
submission deadline 30 Jun 2026 | 6 articles | Viewed by 9257 | Submission Open
Keywords: pulmonary diseases; diagnostics; therapeutics
(This special issue belongs to the Section Molecular Medicine)
Polyphosphate (PolyP) in Health and Disease
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 5984 | Submission Open
Keywords: polyphosphate; polyP; biomarker and therapeutic target
(This special issue belongs to the Section Natural and Bio-derived Molecules)
New Insights into Protein Aggregation in Condensed and Amyloid States submission deadline 30 Jun 2026 | 3 articles | Viewed by 5814 | Submission Open
Keywords: proteinopathies; protein aggregation; physico-chemical and biological properties of amyloid fibrils and protein condensates; signal and light transduction; interaction with lipid membranes; aggregating protein interactomes; bioinformatics and machine learning; molecular dynamics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Jun 2026 | 4 articles | Viewed by 5712 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Jun 2026 | 5 articles | Viewed by 4965 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 30 Jun 2026 | 2 articles | Viewed by 4738 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
New Insights into Stem Cell-Derived Exosomes in Human Health and Disease
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3957 | Submission Open
Keywords: stem cells; exosomes; regenerative medicine; diagnostics
(This special issue belongs to the Section Cellular Biochemistry)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3609 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
(This special issue belongs to the Section Biological Factors)
Lipid Signaling in Human Disease
edited by and Felicity Ashcroft
submission deadline 30 Jun 2026 | 3 articles | Viewed by 3564 | Submission Open
Keywords: lipid signaling pathways; membrane-derived lipid signaling molecules; inflammation mechanisms; cellular disease mechanisms; phospholipids; phospholipases; glycerophospholipids; sphingolipids
(This special issue belongs to the Section Lipids)
Mitochondria as a Target for Tissue Repair and Regeneration
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 3528 | Submission Open
Keywords: mitochondria; trauma; tissue repair; regeneration; inflammation; mitochondrial DAMPs; mitochondrial biogenesis; mitophagy
(This special issue belongs to the Section Molecular Biology)
Molecular Basis and Novel Treatment of Epilepsy
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 3420 | Submission Open
Keywords: epilepsy; genetic basis; epileptogenesis; antiseizure drugs; novel treatment; translational research
(This special issue belongs to the Section Molecular Biology)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 30 Jun 2026 | 2 articles | Viewed by 3035 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications submission deadline 30 Jun 2026 | 1 articles | Viewed by 2521 | Submission Open
Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine
(This special issue belongs to the Section Cellular Biochemistry)
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2343 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies
edited by and Pragnya Rao Donthineni
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2278 | Submission Open
Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis
(This special issue belongs to the Section Cellular Biochemistry)
Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function submission deadline 30 Jun 2026 | 2 articles | Viewed by 2223 | Submission Open
Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology
(This special issue belongs to the Section Cellular Biochemistry)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2126 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Exercise Immunology: Molecular Mechanisms and Health Applications
edited by , , Michał Sławiński and
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2078 | Submission Open
Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors
(This special issue belongs to the Section Molecular Biology)
Immune Response to Allergens submission deadline 30 Jun 2026 | 1 articles | Viewed by 1850 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System submission deadline 30 Jun 2026 | 1 articles | Viewed by 1437 | Submission Open
Keywords: mesenchymal stem/stromal cells; extracellular vesicles  ; musculoskeletal regeneration  ; immunomodulation  ; anabolism  ; cell therapy  ; cell-free therapy  ; secretome
Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine
edited by Xiao Fan and Youngil Lee
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1222 | Submission Open
Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy
(This special issue belongs to the Section Molecular Genetics)
Exploring Physical Mechanisms in Inflammation Regulation submission deadline 30 Jun 2026 | 1 articles | Viewed by 1100 | Submission Open
Keywords: physical stimuli; transduction; magnetic field; electric field; magnetotherapy; laser therapy
(This special issue belongs to the Section Biological Factors)
Soft Matter and Self-Assembly: From Biomaterials to Nanomaterials
edited by Caterina Ricci and
submission deadline 30 Jun 2026 | Viewed by 354 | Submission Open
Keywords: soft matter; self-assembly; biomaterials; nanomaterials; bioinspired materials; drug delivery; responsive materials; tissue engineering; nanotechnology; molecular organization
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Jun 2026 | Viewed by 351 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Bacterial Molecular Biology: Stress Responses and Adaptation
edited by Alba Blesa, Lucía García Pastor and Mercedes Sánchez-Costa
submission deadline 30 Jun 2026 | Viewed by 318 | Submission Open
Keywords: bacterial stress response; adaptation; antimicrobial resistance; virulence; microbial persistence; extremophiles; environmental signalling; phenotypic plasticity; HGT; regulation networks
(This special issue belongs to the Section Molecular Biology)
Novel Biomarkers in Breast Cancer: Leveraging Multi-Omics and AI for Discovery and Validation
edited by Konstantinos Venetis, and Marianna D'Ercole
submission deadline 30 Jun 2026 | Viewed by 293 | Submission Open
Keywords: breast cancer; biomarkers; liquid biopsy; multi-omics; digital pathology
(This special issue belongs to the Section Molecular Biomarkers)
Second Messenger Systems in Cellular Communication and Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 291 | Submission Open
Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases: 3rd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 276 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; diabetes; obesity; inflammation; oxidative stress; biomarkers; microRNA; extracellular vesicles; cardiopulmonary disease
Molecular and Physiological Regulation of Biomechanical Signalling
edited by
submission deadline 30 Jun 2026 | Viewed by 270 | Submission Open
Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1& 2; microfluidics
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