CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

Dear Colleagues,

With the evolution of CRISPR-directed gene editing for the treatment of human diseases, the field of genetic medicine now holds more promise than ever. While most applications of gene editing tools for cancer have been indirect, such as the remodeling of T cells, direct in vivo strategies are beginning to emerge. In this Special Issue, we request contributions that center on using editors that orchestrate direct genetic changes within the tumor genome. We invite submissions exploring CRISPR gene editing from fundamental mechanism-of-action studies to translational applications in cancer therapy. Topics of interest include molecular insights of CRISPR/Cas systems in cancer-based models; novel approaches for altering the tumor microenvironment or disrupting oncogenic pathways; strategies for improving safety, efficiency, or precision of CRISPR/Cas systems for cancer therapy; and diagnostic applications of CRISPR technologies as tools for detection or molecular profiling. We accept submissions that describe novel delivery mechanisms that advance our knowledge of tissue or tumor-specific targeting, delivering the gene editing payload to the cell type where it can have the most positive impact.

Dr. Eric B. Kmiec
Dr. Kelly Banas
Guest Editors

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